公开(公告)号：US07196068B2

公开(公告)日：2007-03-27

申请号：US10463676

申请日：2003-06-18

申请人： Sunghoon Kim ,  Bum-Joon Park

发明人： Sunghoon Kim ,  Bum-Joon Park

IPC分类号： A01N43/04 ,  C12Q1/68 ,  C12N15/64 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K38/1841 ,  A61K48/00

摘要： The present invention relates to a method for treating cancer using p38/JTV-1 and a method for screening pharmaceutical composition for treating cancer. More particularly, this invention relates to the method for treating cancer, which comprises administering the effective amount of p38/JTV-1 protein or a nucleic acid encoding for said protein to the patient and the method for screening a pharmaceutical composition for treating cancer characterized by selecting a substance having an effect on the increase of the activity of the p38/JTV-1 protein and the intracellular level thereof.The method according to the invention can be effectively used to treat cancer through the mechanism of suppressing the proliferation of cancer cells by binding to FBP (FUSE-binding protein) and thereby promoting the ubiquitination of FBP to downregulate c-myc gene, which is a proto-oncogene, and the mechanism of promoting the apoptosis of cells by binding to PDK-1 (phosphoinositide-dependent protein) and thereby inhibiting the phosphorylation of AKT (serine/threonine kinase). Also, p38/JTV-1 can be used as a target for screening of new anticancer agents, by virtue of such regulation mechanisms of p38/JTV-1.

摘要翻译： 本发明涉及使用p38 / JTV-1治疗癌症的方法以及用于筛选用于治疗癌症的药物组合物的方法。 更具体地，本发明涉及治疗癌症的方法，其包括向患者施用有效量的p38 / JTV-1蛋白质或编码所述蛋白质的核酸，以及用于筛选用于治疗癌症的药物组合物的方法，其特征在于 选择对p38 / JTV-1蛋白的活性增加和细胞内水平有影响的物质。

公开(公告)号：US20060110397A1

公开(公告)日：2006-05-25

申请号：US11264725

申请日：2005-11-01

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K48/00 ,  A61K39/395 ,  C12P21/06

CPC分类号： G01N33/57423 ,  C07K16/30 ,  G01N33/57438 ,  G01N2500/00

摘要： The present invention relates to a variant of AIMP2 lacking exon 2, named as AIMP2-DX2, which is specifically expressed in cancer cells. The AIMP2-DX2 protein and gene can be successfully used in the development of diagnosis and treatment of cancer.

摘要翻译： 本发明涉及缺少外显子2的AIMP2的变体，命名为AIMP2-DX2，其在癌细胞中特异性表达。 AIMP2-DX2蛋白和基因可以成功应用于癌症诊断和治疗的发展。

公开(公告)号：US07037505B2

公开(公告)日：2006-05-02

申请号：US10823730

申请日：2004-04-14

申请人： Sunghoon Kim ,  Young-Gyu Ko

发明人： Sunghoon Kim ,  Young-Gyu Ko

IPC分类号： A61K38/16

CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K2039/55522

摘要： The present invention relates to an immunological enhancement agent, more particularly, to an immunological enhancement agent comprising peptide having an amino acid sequence represented by SEQ ID NO:1 to SEQ ID NO:3 as an effective component.The peptides according to the present invention comprising the N-terminal domain of the p43 protein have excellent cytokine activity to improve an immune response so that they can be used as an effective immunological enhancement agent.

摘要翻译： 本发明涉及免疫增强剂，更具体地，涉及含有SEQ ID NO：1至SEQ ID NO：3所示氨基酸序列作为有效成分的肽的免疫增强剂。 包含p43蛋白的N-末端结构域的本发明的肽具有优异的细胞因子活性，以改善免疫应答，从而可以将其用作有效的免疫增强剂。

公开(公告)号：US08463965B2

公开(公告)日：2013-06-11

申请号：US13157061

申请日：2011-06-09

申请人： Dongwon Park ,  Sunghoon Kim ,  Sungwon Kim ,  Chongho Lee

发明人： Dongwon Park ,  Sunghoon Kim ,  Sungwon Kim ,  Chongho Lee

IPC分类号： G06F3/00 ,  G06F13/00

CPC分类号： G06F3/147

摘要： An iDP interface test method includes transmitting test clocks to an iDP sink device; determining whether or not a link clock lock operation in the iDP sink device is successful based on a measurement result of an HPD signal when a clock lock operation for the test clocks is performed; transmitting test data and arbitrary video data to the iDP sink device if the link clock lock operation in the iDP sink device is successful; determining whether or not a symbol lock operation in the iDP sink device is successful when the symbol lock operation for the test data and the arbitrary video data is performed; and comparing a count result with a predetermined reference value, and determining link stability of the iDP sink device based on the comparison result.

摘要翻译： iDP接口测试方法包括将测试时钟发送到iDP宿设备; 当执行用于测试时钟的时钟锁定操作时，基于HPD信号的测量结果，确定iDP宿设备中的链路时钟锁定操作是否成功; 如果iDP宿设备中的链路时钟锁定操作成功，则将测试数据和任意视频数据发送到iDP宿设备; 当执行测试数据和任意视频数据的符号锁定操作时，确定iDP宿设备中的符号锁定操作是否成功; 以及将计数结果与预定参考值进行比较，并且基于比较结果确定iDP宿设备的链路稳定性。

公开(公告)号：US08400567B2

公开(公告)日：2013-03-19

申请号：US13157950

申请日：2011-06-10

申请人： Chongho Lee ,  Sunghoon Kim ,  Sungwon Kim ,  Dongwon Park

发明人： Chongho Lee ,  Sunghoon Kim ,  Sungwon Kim ,  Dongwon Park

IPC分类号： H03L7/00

CPC分类号： G09G5/008 ,  G09G3/2096 ,  G09G2370/14

摘要： A method for recovering pixel clocks based on an iDP interface includes selecting a prime factor closest to VA or HA from prime factors of X, and selecting a value obtained by subtracting VA from the selected prime factor, as VB, in Mvid = ( HA + HB ) × ( VA + VB ) X , where HA indicates a horizontal active period, HB indicates a horizontal blank interval, VA indicates a vertical active period, and VB indicates a vertical blank interval, fixing the selected VB value, and selecting a total of HB within one frame period and the number of lanes under a condition that Mvid has an integer value, and recovering pixel clocks by multiplying a frequency of link symbol clocks of data received via the lanes by a multiplication of Mvid/48.

摘要翻译： 用于基于iDP接口恢复像素时钟的方法包括从素数因子X中选择最接近VA或HA的素数因子，并且选择通过从所选素数因子中减去VA获得的值作为VB，在Mvid =（HA + HB）×（VA + VB）X，其中HA表示水平有效期，HB表示水平空白间隔，VA表示垂直有效期，VB表示垂直空白间隔，固定所选择的VB值， 在一个帧周期内的HB和在Mvid具有整数值的条件下的通道数，并且通过乘以通过车道接收的数据的链路符号时钟的频率乘以Mvid / 48来恢复像素时钟。

公开(公告)号：US20120253113A1

公开(公告)日：2012-10-04

申请号：US13364876

申请日：2012-02-02

申请人： Olajire Idowu ,  Sunghoon Kim

发明人： Olajire Idowu ,  Sunghoon Kim

IPC分类号： A61B1/00

CPC分类号： A61B1/00094 ,  A61B1/00165 ,  A61B1/05 ,  A61M27/00 ,  A61M2250/00

摘要： Pleural empyema removal devices are provided and enable the removal of empyema from the pleural cavity of a human or veterinary patient. The pleural empyema removal devices may be coupled with one or more additional devices, such as suction source, gas source, light source and/or camera source, and monitor. The devices and systems including the devices facilitate the removal of empyema from the pleural cavity of a patient while providing protections from damage to untargeted tissues. The devices, systems, and methods can be used in the treatment process to treat pleural empyema resulting from pleural effusions and infections stemming from various illnesses and disorders, such as pneumonia.

摘要翻译： 提供胸膜积液除去装置，并能够从人或兽医患者的胸膜腔中除去脓胸。 胸膜积液除去装置可以与一个或多个附加装置（例如抽吸源，气体源，光源和/或照相机源）和监视器耦合。 包括装置的装置和系统有助于从患者的胸膜腔中除去脓肿，同时提供保护以免对非靶向组织的损伤。 装置，系统和方法可用于治疗由胸膜积液引起的胸膜积液和由各种疾病和疾病如肺炎引起的感染的治疗过程。

公开(公告)号：US20110310252A1

公开(公告)日：2011-12-22

申请号：US13157061

申请日：2011-06-09

申请人： Dongwon Park ,  Sunghoon Kim ,  Sungwon Kim ,  Chongho Lee

发明人： Dongwon Park ,  Sunghoon Kim ,  Sungwon Kim ,  Chongho Lee

IPC分类号： H04N17/04

CPC分类号： G06F3/147

摘要： An iDP interface test method includes transmitting test clocks to an iDP sink device; determining whether or not a link clock lock operation in the iDP sink device is successful based on a measurement result of an HPD signal when a clock lock operation for the test clocks is performed; transmitting test data and arbitrary video data to the iDP sink device if the link clock lock operation in the iDP sink device is successful; determining whether or not a symbol lock operation in the iDP sink device is successful when the symbol lock operation for the test data and the arbitrary video data is performed; and comparing a count result with a predetermined reference value, and determining link stability of the iDP sink device based on the comparison result.

摘要翻译： iDP接口测试方法包括将测试时钟发送到iDP宿设备; 当执行用于测试时钟的时钟锁定操作时，基于HPD信号的测量结果，确定iDP宿设备中的链路时钟锁定操作是否成功; 如果iDP宿设备中的链路时钟锁定操作成功，则将测试数据和任意视频数据发送到iDP宿设备; 当执行测试数据和任意视频数据的符号锁定操作时，确定iDP宿设备中的符号锁定操作是否成功; 以及将计数结果与预定参考值进行比较，并且基于比较结果确定iDP宿设备的链路稳定性。

公开(公告)号：US20110256119A1

公开(公告)日：2011-10-20

申请号：US13123522

申请日：2009-10-12

申请人： Sunghoon Kim ,  Min Chul Park

发明人： Sunghoon Kim ,  Min Chul Park

IPC分类号： A61K38/53 ,  C07H21/00 ,  A61P35/02 ,  A61K31/7088 ,  A61P35/00 ,  C12N15/63 ,  C12N9/00

CPC分类号： C12Y601/01014 ,  A61K38/53

摘要： The present invention is related to a anticancer composition comprising full length GRS protein or a fragment thereof, a nucleic acid encoding the GRS protein or a fragment thereof. Since the GRS proteins or fragments thereof have activity to induce apoptosis of cancer cell specifically, a composition comprising the GRS proteins or fragments thereof or a nucleic acid encoding thereof may be useful to treatment of cancer.

摘要翻译： 本发明涉及包含全长GRS蛋白或其片段，编码GRS蛋白或其片段的核酸的抗癌组合物。 由于GRS蛋白质或其片段具有特异性诱导癌细胞凋亡的活性，所以包含GRS蛋白质或其片段或其编码核酸的组合物可用于治疗癌症。

公开(公告)号：US20110136119A1

公开(公告)日：2011-06-09

申请号：US13011174

申请日：2011-01-21

申请人： Sunghoon Kim ,  Jin Woo Choi

发明人： Sunghoon Kim ,  Jin Woo Choi

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/04

摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer

摘要翻译： 本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 AIMP2-DX2基因和靶向AIMP2-DX2的siRNA可以成功应用于癌症诊断和治疗的发展

公开(公告)号：US20110117572A1

公开(公告)日：2011-05-19

申请号：US13011386

申请日：2011-01-21

申请人： Sunghoon Kim ,  Jin Woo Choi

发明人： Sunghoon Kim ,  Jin Woo Choi

IPC分类号： G01N33/566 ,  C07K16/40

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/04

摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer

摘要翻译： 本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 AIMP2-DX2基因和靶向AIMP2-DX2的siRNA可以成功应用于癌症诊断和治疗的发展