公开(公告)号：US20120277390A1

公开(公告)日：2012-11-01

申请号：US13453196

申请日：2012-04-23

申请人： Takayuki Hiratani ,  Shinnosuke Koji ,  Kazumichi Nakahama

发明人： Takayuki Hiratani ,  Shinnosuke Koji ,  Kazumichi Nakahama

IPC分类号： C08F4/04

CPC分类号： C08F2/18 ,  C08F2/38 ,  C08F112/08 ,  C08F120/14 ,  C08F212/08 ,  C08F220/14

摘要： A method for producing polymer particles includes a suspension step of suspending a first liquid mixture containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule in a second liquid mixture containing water and an iodide ion to prepare a suspension containing an oil droplet having the first liquid mixture; a synthesis step of synthesizing an iodine compound by allowing a radical generated by cleavage of the radical polymerization initiator to react with the iodine molecule in the oil droplet; and a polymerization step of polymerizing the oily olefin monomer in the oil droplet.

摘要翻译： 制备聚合物颗粒的方法包括将含有油性烯烃单体，自由基聚合引发剂和碘分子的第一液体混合物悬浮在含有水和碘离子的第二液体混合物中以制备含有油滴的悬浮液的悬浮步骤 具有第一液体混合物; 通过使自由基聚合引发剂的裂解产生的自由基与油滴中的碘分子反应来合成碘化合物的合成步骤; 以及在油滴中聚合油性烯烃单体的聚合步骤。

公开(公告)号：US08262791B2

公开(公告)日：2012-09-11

申请号：US13075084

申请日：2011-03-29

申请人： Shinnosuke Koji ,  Kazumichi Nakahama ,  Shoji Koike

发明人： Shinnosuke Koji ,  Kazumichi Nakahama ,  Shoji Koike

IPC分类号： C09D11/00 ,  C09B63/00

CPC分类号： C09B67/0086 ,  B82Y30/00 ,  C09B67/0005 ,  C09B67/0096 ,  C09D11/023 ,  C09D11/328

摘要： The present invention provides coloring particles containing a dye and a water-insoluble low-molecular-weight dispersant, wherein the average particle size of the coloring particles is 10 nm or more and 80 nm or less; the solubility parameter of the dye in water with a pH of 6.0 to 10.0 is 9.20 or more, the solubility parameter being represented by formula (1); and the content of the dye and the content of the water-insoluble low-molecular-weight dispersant satisfy a relationship of formula (2).

摘要翻译： 本发明提供了含有染料和水不溶性低分子量分散剂的着色颗粒，其中着色颗粒的平均粒径为10nm以上且80nm以下， 该染料在pH为6.0〜10.0的水中的溶解度参数为9.20以上，溶解度参数由式（1）表示; 并且染料的含量和水不溶性低分子量分散剂的含量满足式（2）的关系。

公开(公告)号：US08080430B2

公开(公告)日：2011-12-20

申请号：US11697856

申请日：2007-04-09

申请人： Takeshi Imamura ,  Tetsunori Ojima ,  Kazumichi Nakahama

发明人： Takeshi Imamura ,  Tetsunori Ojima ,  Kazumichi Nakahama

IPC分类号： G01N33/553

CPC分类号： G01N33/54353 ,  G01N33/544 ,  G01N33/553

摘要： In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such a change in the volume of the polymer matrix is measured as a change in the optical properties of the metal structure, and the target is detected. Thereby, the present invention provides a target substance detection material having good operability and high performance, which includes a metal structure as a labeled form, and a target substance detection method for detecting the presence or absence of a target substance in a specimen and/or the concentration thereof, using the material.

摘要翻译： 在本发明中，包含金属结构的靶物质检测材料，靶物质捕获单元和保持金属结构的聚合物基质和目标物质捕获单元捕获目标物质，结果，体积 的聚合物基体改变了。 测量聚合物基体的体积的这种变化，作为金属结构的光学特性的变化，并检测靶。 因此，本发明提供了具有良好的可操作性和高性能的目标物质检测材料，其包括作为标记形式的金属结构和用于检测样品中目标物质的存在或不存在的目标物质检测方法和/或 其浓度，使用该材料。

公开(公告)号：US20110054094A1

公开(公告)日：2011-03-03

申请号：US12869425

申请日：2010-08-26

申请人： Kazumichi Nakahama ,  Takayuki Hiratani ,  Shoji Koike

发明人： Kazumichi Nakahama ,  Takayuki Hiratani ,  Shoji Koike

IPC分类号： C09D11/10

CPC分类号： C09B67/0005 ,  B82Y30/00 ,  C09B63/00 ,  C09B67/0013 ,  C09B67/0097 ,  C09D11/32

摘要： In color particles containing a dye and a polymer compound, the average particle diameter of the color particles measured by a dynamic light scattering method is 10 to 80 nm, the content of the dye of the color particles is in the range of 60 to 90 percent by mass, and the dye has a solubility index of 7.50 or more in water having a pH of 6.0 to 11.0, the solubility index being represented by the following equation (1): Solubility Index=log(1/Aqueous Solubility of Dye [mol/L]).

摘要翻译： 在含有染料和高分子化合物的彩色粒子中，通过动态光散射法测定的着色粒子的平均粒径为10〜80nm，着色粒子的染料含量为60〜90％ ，染料在pH为6.0〜11.0的水中的溶解度指数为7.50以上，溶解度指数由下式（1）表示：溶解度指数= log（1 /染料的水溶性[mol / L]）。

公开(公告)号：US20100330704A1

公开(公告)日：2010-12-30

申请号：US12865063

申请日：2009-06-06

申请人： Kazumichi Nakahama ,  Miki Ueda ,  Akira Kuriyama ,  Takayuki Hiratani ,  Ikuo Nakazawa

发明人： Kazumichi Nakahama ,  Miki Ueda ,  Akira Kuriyama ,  Takayuki Hiratani ,  Ikuo Nakazawa

IPC分类号： G01N33/543

CPC分类号： G01N33/54326 ,  B82Y25/00 ,  H01F1/0054

摘要： To provide a method for producing composite particles small in particle size, excellent in mono-dispersibility, high in magnetic-substance content per particle, large in saturation magnetization, excellent in dispersion stability and having non-specific adsorption suppressibility.The method includes (1) mixing a first liquid and particles to prepare a mixture solution;(2) mixing the mixture solution and a second liquid to prepare an emulsion containing a dispersoid formed of the first liquid and the particles; (3) mixing a polymer compound with the emulsion; and (4) fractionating the emulsion to extract the first liquid from the dispersoid to produce the composite particles each containing the particles and the polymer compound, characterized in that the dispersoid has a single-peak particle size distribution and a dispersity index (Dhw/Dhn) calculated from a number-average hydrodynamic particle size (Dhn) and a weight-average hydrodynamic particle size (Dhw) is 1.5 or less.

摘要翻译： 为了提供粒径小，单分散性优异，每粒子的磁性体含量高的饱和磁化强度，分散稳定性优异，具有非特异性吸附抑制性的复合粒子的制造方法。 该方法包括：（1）混合第一液体和颗粒以制备混合溶液;（2）将混合溶液和第二液体混合以制备含有由第一液体和颗粒形成的分散质的乳液; （3）将高分子化合物与乳液混合; （4）分级乳液以从分散体中提取第一液体以产生每个含有颗粒和高分子化合物的复合颗粒，其特征在于分散体具有单峰粒度分布和分散指数（Dhw / Dhn ）和重均流体动力学粒径（Dhw）计算为1.5以下。

公开(公告)号：US20100163777A1

公开(公告)日：2010-07-01

申请号：US12377661

申请日：2007-08-08

申请人： Kazumichi Nakahama

发明人： Kazumichi Nakahama

IPC分类号： H01F1/42 ,  B32B9/00

CPC分类号： A61K9/0009 ,  A61K9/5094 ,  A61K41/0052 ,  A61K49/1824 ,  A61K49/1857 ,  A61K49/1869 ,  B82Y5/00 ,  Y10T428/2982

摘要： Magnetic particles containing a magnetic material and a biodegradable polymeric compound; the magnetic particles having average particle diameter in the range of from 10 nm or more to 1,000 nm or less.

摘要翻译： 含有磁性材料和可生物降解的聚合物的磁性颗粒; 磁性粒子的平均粒径在10nm以上至1000nm以下的范围。

公开(公告)号：US20090148346A1

公开(公告)日：2009-06-11

申请号：US12065720

申请日：2006-10-03

申请人： Kazuhiro Ban ,  Kazumichi Nakahama ,  Miki Ogawa

发明人： Kazuhiro Ban ,  Kazumichi Nakahama ,  Miki Ogawa

IPC分类号： G01N21/00 ,  C08L33/02

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  G01N33/54393

摘要： A structural member having a binding functional group on a substrate for binding a capturing molecule capable of capturing a target substance, characterized in that the substrate binds to one end of a polymer which includes at the other end those to which the binding functional group is bound and those to which a suppressing functional group for suppressing adsorption of biological molecules to the structural member and that the suppressing functional group is also bound to a side chain of the polymer.

摘要翻译： 一种在底物上具有结合能捕获靶物​​质的捕获分子的结合官能团的结构部件，其特征在于，所述底物与聚合物的一端结合，所述聚合物的另一端包含结合官能团所结合的那些 以及抑制生物分子吸附到结构构件上的抑制官能团，抑制官能团也与聚合物的侧链结合的那些。

公开(公告)号：US08513024B2

公开(公告)日：2013-08-20

申请号：US12517053

申请日：2009-02-04

申请人： Kazumichi Nakahama

发明人： Kazumichi Nakahama

IPC分类号： G01N27/00

CPC分类号： G01N33/54333

摘要： Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized on a sensing element and with a second target substance trapping member immobilized on a gel particle to hold the gel particle on the sensing element; adjusting a magnetic marker precursor including the gel particle and a magnetic material precursor existing in the gel particle by bringing the magnetic material precursor into contact with the gel particle; synthesizing a magnetic material from the magnetic material precursor held on the gel particle, thereby adjusting the magnetic markers; and detecting the magnetic markers with the sensing element.

摘要翻译： 本发明提供能够提高磁性生物传感器的检测灵敏度和定量性能的目标物质的检测方法，同时保持磁性标记物的单分散性和分散稳定性，包括以下步骤：将样品溶液中的目标物质与第一目标物质 固定在感测元件上的捕获构件和固定在凝胶颗粒上的第二目标物质捕获构件，以将凝胶颗粒保持在感测元件上; 通过使磁性材料前体与凝胶颗粒接触来调节包含凝胶颗粒的磁性标记前体和存在于凝胶颗粒中的磁性材料前体; 从保持在凝胶粒子上的磁性材料前体合成磁性材料，从而调整磁性标记; 并用感测元件检测磁标记。

公开(公告)号：US20100234561A1

公开(公告)日：2010-09-16

申请号：US12377972

申请日：2007-08-08

申请人： Kazumichi Nakahama

发明人： Kazumichi Nakahama

IPC分类号： C08J3/14

CPC分类号： C08J3/14

摘要： A process for producing fine particles is provided including the steps of (1) preparing a solution having a viscosity of 20 mPa·s or less at 25° C. by using a polymer and a first solvent, (2) mixing the solution with a second solvent to prepare an emulsion and (3) removing the first solvent from the emulsion to obtain fine particles containing the polymer.

摘要翻译： 提供一种微粒生产方法，包括以下步骤：（1）通过使用聚合物和第一溶剂在25℃下制备粘度为20mPa·s或更低的溶液，（2）将溶液与 第二溶剂以制备乳液和（3）从乳液中除去第一溶剂以获得含有聚合物的细颗粒。

公开(公告)号：US20090000360A1

公开(公告)日：2009-01-01

申请号：US12162789

申请日：2007-03-30

申请人： Miki Ogawa ,  Masato Minami ,  Takeshi Imamura ,  Takashi Ikeda ,  Kazumichi Nakahama

发明人： Miki Ogawa ,  Masato Minami ,  Takeshi Imamura ,  Takashi Ikeda ,  Kazumichi Nakahama

IPC分类号： G01N30/62 ,  G06K7/08

CPC分类号： G01N33/54373 ,  Y10S436/807

摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting parts and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ1ψ3>0 and ψ2=0,  i) ψ1ψ2 0, and |ψ2|>|ψ3|, and  iii) ψ1ψ2

摘要翻译： 本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法， 或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。 样品溶液中的磁性标记的表面电位psi1，检测部分的表面电位psi2和非检测部分的表面电位psi3满足以下关系式i）至iv）中的任何一个：<？in-line -formulae description =“In-line Formulas”end =“lead”？> psi1psi3> 0 and psi2 = 0，i）<？in-line-formula description =“In-line Formulas”end =“tail”？> ？in-line-formula description =“In-line Formulas”end =“lead”？> psi1psi2 <0 and psi3 = 0，ii）<？in-line-formula description =“In-line Formulas”end =“tail “？> <？in-line-formula description =”在线公式“end =”lead“？> psi1psi2 <0，psi2psi3> 0和| psi2 |> | psi3 |，以及iii） -formulae description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？> psi1psi2 <0 and psi2psi3 <0; iv）<？in-line-formula description =“In-line Formulas”end =“tail”？>，由磁性标签承载的目标物质由检测部分所承载的主捕获体或目标物质 由被检测部分承载的主要捕获体捕获的捕获体被由磁性标签承载的次级捕获体俘获。