Cyclic adenosine monophosphate 8-substituted derivatives
    31.
    发明授权
    Cyclic adenosine monophosphate 8-substituted derivatives 失效
    环磷酸腺苷8-取代衍生物

    公开(公告)号:US4048307A

    公开(公告)日:1977-09-13

    申请号:US616356

    申请日:1975-09-24

    IPC分类号: C07H19/20 A61K31/70

    CPC分类号: C07H19/20

    摘要: Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO KNOWN CYCLIC ADENOSIENE DERIVATIVES IN BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES, ESPECIALLY PDE-inhibiting activity and membrane permeability. Accordingly, these derivatives are very effective for remedying and controlling diseases caused by disorder of the intracellular cyclic adenosine monophosphate level, such as asthma and scabies. These derivaives can readily be synthesized by reacting an 8-halogeno cyclic adenosine monophosphate of the following general formula ##STR2## wherein X is a halogen atom such as bromine, with an alkali metal salt of a linear alkylmercaptan having 3 to 13 carbon atoms in the alkyl group or a linear alkylamine having 3 to 13 carbon atoms in the alkyl group.

    摘要翻译: 由以下通式表示的新型环状腺苷一磷酸酯衍生物:其中A代表-S-或-NH-,n是2至12的整数,ARE高于生物和药理学活动中已知的循环腺嘌呤衍生物, 特别是PDE抑制活性和膜通透性。 因此,这些衍生物对于补救和控制由细胞内环腺苷酸单磷酸酯水平紊乱引起的疾病,如哮喘和sc疮非常有效。 这些衍生物可以容易地通过使下列通式为“IMAGE”的8-卤代环腺苷单磷酸酯与其中X为卤素原子如溴的碳原子数为3〜13的直链烷基硫醇的碱金属盐反应 烷基或烷基中具有3至13个碳原子的直链烷基胺。

    Simulation program and simulation apparatus
    35.
    发明申请
    Simulation program and simulation apparatus 审中-公开
    仿真程序和仿真设备

    公开(公告)号:US20050278248A1

    公开(公告)日:2005-12-15

    申请号:US11059450

    申请日:2005-02-17

    IPC分类号: G06F19/00 G06F17/60

    摘要: Simulation for evaluating approval/rejection of an action plan of the type in which work breakdown struction is changed by influences of external risk factors is achieved. A simulation apparatus includes a plan/risk input portion for accepting input of action plan data and risk scenario data, a plan/risk simulation portion for conducting simulation of an action plan by using the action plan data and the risk scenario data so accepted, and a plan evaluation output portion for evaluating a simulation result. The plan/risk simulation portion simulates occurrence of a risk phenomenon by using the risk scenario data, determines influence information given by the risk phenomenon to the action plan when the risk phenomenon is simulated as occurring and conducts simulation of the action plan by reflecting the influences of the risk scenario on the action plan by using the influence information so determined.

    摘要翻译: 通过外部风险因素的影响,对工作分解结构改变类型的行动计划的批准/拒绝进行模拟。 模拟装置包括用于接受行动计划数据和风险情景数据的输入的计划/风险输入部分,用于通过使用所接受的动作计划数据和风险情景数据来进行行动计划的模拟的计划/风险模拟部分,以及 用于评估模拟结果的计划评估输出部分。 计划/风险模拟部分通过使用风险情景数据模拟风险现象的发生,将风险现象模拟为风险现象的影响信息确定为行动计划,并通过反映影响来对行动计划进行模拟 的行动计划中的风险情况通过使用如此确定的影响信息。

    Project pre-review estimate method
    36.
    发明申请
    Project pre-review estimate method 审中-公开
    项目预评估估计方法

    公开(公告)号:US20050010459A1

    公开(公告)日:2005-01-13

    申请号:US10885036

    申请日:2004-07-07

    摘要: A project pre-review estimate method capable of estimating influence of alteration in each process of a project on the whole process (project) considering structural alteration and fluctuating values regarding each process and their factors is provided. The project pre-review estimate method is carried out employing a process evaluation procedure which calculates quantitative and structural alteration amounts of the process plan using not only information on constraints (which has been used by conventional techniques) but also scenario information (in which probability of occurrence of a risk (i.e. a factor of alteration to a process) and the content/degree of influence regarding alteration of arbitrary processes caused by the occurrence of the risk are defined in a scenario format) and information for correcting parameters of the scenario by use of qualitative information on the project.

    摘要翻译: 提供了一种考虑到每个过程及其因素的结构变化和波动值的项目预评估估计方法,其能够估计项目每个过程中的变更对整个过程(项目)的影响。 使用过程评估程序进行项目预评估估计方法,该过程评估程序不仅使用关于约束的信息(已经由常规技术使用)来计算过程计划的定量和结构变化量,而且还使用情景信息(其中概率 风险发生的风险(即过程变更的因素)以及由风险发生引起的任意过程变更的影响的内容/程度在场景格式中定义)以及用于通过使用来修正场景参数的信息 关于项目的定性信息。

    Method and apparatus for displaying graphs

    公开(公告)号:US06414691B1

    公开(公告)日:2002-07-02

    申请号:US09492080

    申请日:2000-01-27

    IPC分类号: G06T1100

    CPC分类号: G06T11/206 G06Q30/0201

    摘要: In a graph displaying method for displaying as an analysis subject a collection of constituent members each having a plurality of information parameters, each information parameter of each constituent member is assigned to a display attribute of graphic representation, and a value of the information parameter of each constituent member is converted into a value of the assigned display attribute. Next, a display corresponding to the information parameter of each constituent member is provided by using the converted display attribute value. Then, the value of each information parameter indicating affiliation between constituent members is converted into the display attribute value of a display element which couples display elements of the constituent members, and a display corresponding to the affiliation between the constituent members is provided by using the converted display attribute value.

    Stainless steel material with excellent antibacterial property and process for producing the same
    38.
    发明授权
    Stainless steel material with excellent antibacterial property and process for producing the same 失效
    不锈钢材料具有优良的抗菌性能和生产过程

    公开(公告)号:US06312533B1

    公开(公告)日:2001-11-06

    申请号:US09720864

    申请日:2001-01-02

    IPC分类号: C23C2800

    CPC分类号: A61L2/238 C23C18/42

    摘要: The present invention provides a BA-finished stainless steel product having superior antibacterial properties and corrosion resistance and a method for producing the same. Specifically, after a stainless steel product is subjected to BA treatment, the stainless steel product is immersed in a solution containing Ag ions having a concentration of 0.0001 to 1.0 mol/l so that a BA film contains, in area percentage, 0.0002 to 0.05% of Ag particles and Ag compounds, and further, stainless steel product contains 0.001 to 0.10% by weight of Ag and optionally further contains 0.001 to 0.30% by weight of V.

    摘要翻译: 本发明提供具有优异的抗菌性和耐腐蚀性的BA成品不锈钢制品及其制造方法。 具体地说,在对不锈钢制品进行BA处理后,将不锈钢制品浸渍在含有浓度为0.0001〜1.0mol / l的Ag离子的溶液中,使得BA膜的面积百分比为0.0002〜0.05% 的Ag颗粒和Ag化合物,此外,不锈钢产品含有0.001至0.10重量%的Ag,并且任选地还包含0.001至0.30重量%的V。

    Fluoroquinoline derivative
    39.
    发明授权
    Fluoroquinoline derivative 失效
    氟喹啉衍生物

    公开(公告)号:US5776948A

    公开(公告)日:1998-07-07

    申请号:US728431

    申请日:1996-10-09

    摘要: Antibacterial fluoroquinoline derivatives and salts thereof of the following formula are stable and have low toxicity and high photostability and low cytotoxicity under light irradiation: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen, optionally protected amino, optionally protected aminocarbonyl or optionally protected carboxyl; R.sub.5 is halogen, lower alkyl or optionally protected hydroxyl or is the same as R.sub.2 ; R.sub.6 is lower alkyl; A is CH.sub.2, optionally protected nitrogen or oxygen; and n and m are each an integer of from 0 to 4, provided that n +m is an integer of from 1 to 4.

    摘要翻译: 下式的抗菌氟喹啉衍生物及其盐是稳定的,并且在光照射下具有低毒性和高光稳定性和低细胞毒性:其中R1是氢或低级烷基; R2是氢,任选保护的氨基,任选保护的氨基羰基或任选被保护的羧基; R5是卤素,低级烷基或任意保护的羟基或与R2相同; R6是低级烷基; A是CH 2,任选地保护的氮或氧; n和m各自为0〜4的整数,条件是n + m为1〜4的整数。