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    Posture detection using pressure and other physiologic sensors
    31.
    发明授权
    Posture detection using pressure and other physiologic sensors 有权
    使用压力和其他生理传感器的姿势检测

    公开(公告)号：US08731665B1

    公开(公告)日：2014-05-20

    申请号：US11923286

    申请日：2007-10-24

    申请人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

    发明人： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

    IPC分类号： A61N1/00

    CPC分类号： A61N1/365 ,  A61N1/36535

    摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.

    摘要翻译： 提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。 在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

    SYSTEM AND METHOD FOR IMPLANTING A PHYSIOLOGIC SENSOR ASSEMBLY
    34.
    发明申请
    SYSTEM AND METHOD FOR IMPLANTING A PHYSIOLOGIC SENSOR ASSEMBLY 有权
    用于植入生理传感器组件的系统和方法

    公开(公告)号：US20130296661A1

    公开(公告)日：2013-11-07

    申请号：US13464590

    申请日：2012-05-04

    申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

    发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

    IPC分类号： A61B5/0205 ,  A61B5/103 ,  A61B5/145 ,  A61B5/0215 ,  A61B5/0402

    CPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14532

    摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.

    摘要翻译： 可植入生理传感器组件被配置为植入患者体内。 组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。 模块和压力检测构件在植入之前被分离到患者体内。 压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。 该模块被配置为皮下置于患者体内。

    RF-POWERED COMMUNICATION FOR IMPLANTABLE DEVICE
    35.
    发明申请
    RF-POWERED COMMUNICATION FOR IMPLANTABLE DEVICE 审中-公开
    用于可植入设备的RF供电通信

    公开(公告)号：US20130238056A1

    公开(公告)日：2013-09-12

    申请号：US13413560

    申请日：2012-03-06

    申请人： John W. Poore ,  Gene A. Bornzin

    发明人： John W. Poore ,  Gene A. Bornzin

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37276 ,  A61B5/0031 ,  A61B5/076 ,  A61B2560/0209

    摘要： A communication circuit of an implantable device is coupled to a power source (e.g., including a battery) upon receipt of a radiofrequency (RF) signal at the implantable device. A circuit that controls whether the communication circuit is to be coupled to the power source obtains its power from the received RF signal. Thus, the implantable device is able to perform RF signal monitoring (e.g., RF “sniffing”) without using battery power. Battery power is then used for subsequent communication operations after it has been determined that the implantable device is receiving RF signals (e.g., from a verified external device).

    摘要翻译： 在可植入装置接收到射频（RF）信号时，可植入装置的通信电路耦合到电源（例如，包括电池）。 控制通信电路是否耦合到电源的电路从接收的RF信号获得其功率。 因此，可植入装置能够在不使用电池电力的情况下执行RF信号监视（例如，RF“嗅探”）。 在确定可植入装置正在接收RF信号（例如，从已验证的外部装置）之后，将电池功率用于随后的通信操作。

    SYSTEMS AND METHODS FOR CONTROLLING PACING INDUCED DYSSYNCHRONY TO REDUCE ISCHEMIC INJURY USING AN IMPLANTABLE MEDICAL DEVICE
    36.
    发明申请
    SYSTEMS AND METHODS FOR CONTROLLING PACING INDUCED DYSSYNCHRONY TO REDUCE ISCHEMIC INJURY USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
    使用可植入医疗装置来控制皮肤诱导性神经元以减少异常损伤的系统和方法

    公开(公告)号：US20130204312A1

    公开(公告)日：2013-08-08

    申请号：US13365061

    申请日：2012-02-02

    申请人： Jong Gill ,  Kwangdeok Lee ,  Kyungmoo Ryu ,  Gene A. Bornzin

    发明人： Jong Gill ,  Kwangdeok Lee ,  Kyungmoo Ryu ,  Gene A. Bornzin

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36557 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

    摘要： Techniques are provided for use by an implantable medical device for optimizing the amount of ventricular dyssynchrony induced within a patient during protective pacing. In one example, the device analyzes intracardiac electrogram signals to detect an ischemic event within the heart. The device then delivers pacing stimulus in accordance with adjustable pacing parameters to induce ventricular dyssynchrony within the heart and adjusts the pacing parameters within a range of permissible values to achieve a preferred degree of ventricular dyssynchrony within the patient, so long as there is no significant reduction in left ventricular pumping functionality. Preferably, the pacing parameters are adjusted to maximize or otherwise optimize the degree of dyssynchrony induced within the patient. If a significant reduction in LV pumping functionality is detected, the dyssynchrony-inducing pacing is preferably suspended to avoid any deterioration in the condition of the heart. Techniques for detecting early onset of ischemia are also disclosed.

    摘要翻译： 技术被提供用于由可植入医疗装置用于在保护性起搏期间优化患者内引起的心室不同步的量。 在一个实例中，该装置分析心内电描记信号以检测心脏内的缺血事件。 然后，该装置根据可调整的起搏参数提供起搏刺激，以诱导心脏内的心室不同步，并在允许值的范围内调整起搏参数，以在患者体内达到优选的心室不同步程度，只要没有显着的减少 在左心室泵功能。 优选地，起搏参数被调整以最大化或以其他方式优化患者内诱发的不同步程度。 如果检测到LV泵送功能的显着降低，则优选暂停不同步的起搏，以避免心脏状况的任何恶化。 还公开了用于检测早期发作缺血的技术。

    SINGLE CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE HAVING DUAL CHAMBER SENSING WITH SIGNAL DISCRIMINATION
    37.
    发明申请
    SINGLE CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE HAVING DUAL CHAMBER SENSING WITH SIGNAL DISCRIMINATION 审中-公开
    具有信号识别的双室感觉的单室无内科医疗设备

    公开(公告)号：US20130138006A1

    公开(公告)日：2013-05-30

    申请号：US13485534

    申请日：2012-05-31

    申请人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi

    发明人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi

    IPC分类号： A61B5/042

    CPC分类号： A61B5/042 ,  A61B5/6869 ,  A61N1/368 ,  A61N1/3756

    摘要： A leadless intra-cardiac medical device (LIMD) includes multiple electrodes that allow for stimulation and sensing of the right ventricle (RV) and sensing of the right atrium (RA), even though it is entirely located in the RV. The LIMD includes a housing having a proximal end configured to engage local tissue in the local chamber and electrodes located at multiple locations along the housing. Sensing circuitry is configured to define a far field (FF) channel between a first combination of the electrodes to sense FF signals occurring in the adjacent chamber. The sensing circuitry is configured to define a near field (NF) channel between a second combination of the electrodes to sense NF signals occurring in the local chamber. A controller is configured to analyze the NF and FF signals to determine whether the NF and FF signals collectively indicate that a validated event of interest occurred in the adjacent chamber.

    摘要翻译： 无引线心脏内心脏医疗器械（LIMD）包括多个电极，即使完全位于RV中，也能够对右心室（RV）进行刺激和感测，并检测右心房（RA）。 LIMD包括壳体，其具有被配置为接合局部室中的局部组织的近端和位于沿壳体的多个位置处的电极。 感测电路被配置为在电极的第一组合之间定义远场（FF）通道，以感测在相邻室中发生的FF信号。 感测电路被配置为在电极的第二组合之间限定近场（NF）通道，以感测在局部室中发生的NF信号。 控制器被配置为分析NF和FF信号以确定NF和FF信号是否共同表示在邻近室中发生了有效的感兴趣事件。

    UNITARY DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME
    38.
    发明申请
    UNITARY DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
    单位双室无胸膜内科医疗装置及其相关方法

    公开(公告)号：US20130110219A1

    公开(公告)日：2013-05-02

    申请号：US13352167

    申请日：2012-01-17

    申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

    发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

    IPC分类号： A61N1/05

    CPC分类号： A61N1/059 ,  A61B17/3468 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3962

    摘要： An assembly for introducing a leadless intra-cardiac medical device includes a sheath having an internal passage, wherein the sheath is configured to be maneuvered into the heart of the patient. A housing may be retained within the internal passage, wherein the housing is configured to be pushed out of the sheath, the housing having a first anchoring member configured to anchor the housing to a first implant location within the heart. The assembly may also include an electrode trailing the housing within the internal passage, wherein the electrode is also configured to be pushed out of the sheath. The electrode has a second anchoring member configured to anchor the electrode to a second implant location within the heart. A conductive wire connects the housing to the electrode, wherein movement of the housing out of the sheath causes the electrode to follow the movement to a distal end of the sheath.

    摘要翻译： 用于引入无引线心脏内心脏医疗装置的组件包括具有内部通道的护套，其中护套构造成被操纵到患者的心脏中。 壳体可以被保持在内部通道内，其中壳体构造成被推出护套，壳体具有构造成将壳体锚定到心脏内的第一植入位置的第一锚定构件。 该组件还可以包括在内部通道内拖曳壳体的电极，其中电极还构造成被推出护套。 电极具有被配置为将电极锚定到心脏内的第二植入位置的第二锚定构件。 导电线将壳体连接到电极，其中壳体从鞘的移动导致电极跟随到鞘的远端的运动。

    SYSTEMS AND METHODS FOR ASSESSING HEART FAILURE AND CONTROLLING CARDIAC RESYNCHRONIZATION THERAPY USING HYBRID IMPEDANCE MEASUREMENT CONFIGURATIONS
    39.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING HEART FAILURE AND CONTROLLING CARDIAC RESYNCHRONIZATION THERAPY USING HYBRID IMPEDANCE MEASUREMENT CONFIGURATIONS 有权
    用于评估心脏衰竭和控制使用混合阻抗测量配置的心脏再生治疗的系统和方法

    公开(公告)号：US20130053912A1

    公开(公告)日：2013-02-28

    申请号：US13217554

    申请日：2011-08-25

    申请人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    发明人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    IPC分类号： A61N1/368

    CPC分类号： A61B5/053 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/686 ,  A61N1/36185 ,  A61N1/3627 ,  A61N1/3686

    摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.

    摘要翻译： 提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。 混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。 在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。 基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。 基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。 使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。 以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。