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    Methods and Compositions for Assaying a Sample for an Aggregant
    36.
    发明申请
    Methods and Compositions for Assaying a Sample for an Aggregant 有权
    用于测试聚合物样品的方法和组合

    公开(公告)号：US20140087480A1

    公开(公告)日：2014-03-27

    申请号：US14017127

    申请日：2013-09-03

    Applicant: The Regents of the University of California

    Inventor： Guillermo C. Bazan ,  Bin Liu

    IPC: G01N21/64

    CPC classification number: G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

    Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

    Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

    COMPOSITIONS AND METHODS FOR MODULATING CELLULAR INTERNALIZATION
    38.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATING CELLULAR INTERNALIZATION 有权

    公开(公告)号：US20220089752A1

    公开(公告)日：2022-03-24

    申请号：US17422591

    申请日：2020-01-14

    Applicant: The Regents of the University of California

    Inventor： Bin Liu ,  Namkyung Lee ,  Yang Su ,  Scott Bidlingmaier

    IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

    Abstract: Provided herein are compositions and methods for modulating internalization properties of cell surface molecules, e.g., converting a non-internalizing cell surface antigen into an internalizing one, and vice versa. In some embodiments, provided are engineered antibodies each containing an antigen binding moiety specific for a guide-antigen and another antigen binding moiety specific for an effector antigen, wherein the internalization property of the engineered antibody or functional fragment thereof is determined by a relative surface density ratio of the guide antigen to the effector antigen. Also provided are recombinant cells, recombinant nucleic acids encoding such engineered antibodies, as well as pharmaceutical compositions containing same. The disclosure also provides methods useful for modulating cellular internalization in a cell or a subject, as well as methods for modulating cell-type selective signaling in a subject and/or for the treatment of diseases.

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