公开(公告)号：US09351672B2

公开(公告)日：2016-05-31

申请号：US14493266

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： G01J5/02 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

公开(公告)号：US20160058340A1

公开(公告)日：2016-03-03

申请号：US14938688

申请日：2015-11-11

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.

公开(公告)号：US20150018644A1

公开(公告)日：2015-01-15

申请号：US14504065

申请日：2014-10-01

申请人： Sandeep Gulati ,  Timothy Ruchti ,  Alan Abul-Haj ,  Thomas George ,  Kevin Hazen

发明人： Sandeep Gulati ,  Timothy Ruchti ,  Alan Abul-Haj ,  Thomas George ,  Kevin Hazen

IPC分类号： A61B5/145 ,  G01J5/10 ,  G01J5/08 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/1455 ,  A61B5/6801 ,  G01J3/0218 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/42 ,  G01N21/359 ,  G01N2021/317 ,  G01N2201/062

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a non-uniform detector array, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The non-uniform detector array provides a multitude of distinguishable optical pathlengths, couples to a plurality of optical transmission filters, couples to a plurality of light directing micro-optics, and/or couples to an array of light-emitting diodes.

摘要翻译： 描述了一种非侵入性分析仪装置及其使用方法，其包括近红外源，不均匀检测器阵列和配置成经由分析仪样品光学界面将光子从源引导到检测器的光子传输系统。 非均匀检测器阵列提供多种可区别的光程长度，耦合到多个光传输滤波器，耦合到多个光导微光学器件，和/或耦合到发光二极管阵列。

公开(公告)号：US20150011850A1

公开(公告)日：2015-01-08

申请号：US14493283

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen ,  Vlad Novotny

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen ,  Vlad Novotny

IPC分类号： A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6801 ,  A61B2562/04 ,  A61B2562/046

摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.

摘要翻译： 描述了一种非侵入性分析仪装置及其使用方法，其包括近红外源，检测器和光子传输系统，其被配置为经由分析仪样品光学界面将光子从源引导到检测器。 光子传输系统包括动态位置光导单元，用于在单个分析物浓度测定的测量时间段内改变以下任何一种：半径，能量，强度，位置，入射角，立体角和/或穿透深度 一束进入受试者皮肤的光子。

公开(公告)号：US20050209515A1

公开(公告)日：2005-09-22

申请号：US11012428

申请日：2004-12-14

申请人： Linda Hockersmith ,  Kevin Hazen ,  Timothy Ruchti

发明人： Linda Hockersmith ,  Kevin Hazen ,  Timothy Ruchti

IPC分类号： A61B5/00 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/7415 ,  A61B5/743 ,  A61B5/7475 ,  A61B5/749 ,  A61B2560/0456 ,  G06F19/00 ,  G16H15/00

摘要： The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.

摘要翻译： 本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。 更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。 将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。 或者，葡萄糖浓度通过语音合成器或耳塞输出。 这些信息介绍对于医疗专业人员和最终用户都是有用的。 信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

公开(公告)号：US20150011848A1

公开(公告)日：2015-01-08

申请号：US14493234

申请日：2014-09-22

申请人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

发明人： Timothy Ruchti ,  Alan Abul-Haj ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61M5/172 ,  A61B5/145

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6801 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726

摘要： A noninvasive analyzer apparatus and method of use thereof is described using one or a plurality of sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.

摘要翻译： 使用耦合到监视多个检测区域的至少一个二维检测器阵列的一个或多个样本照明区域来描述非侵入性分析仪装置及其使用方法。 照射时间和/或图案与所选检测区域的控制产生光程长度解析组。 选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。 随后分析路径长度解析的光谱组以确定分析物质。 可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角 。 任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

公开(公告)号：US20060264718A1

公开(公告)日：2006-11-23

申请号：US11168941

申请日：2005-06-27

申请人： Timothy Ruchti ,  Linda Hockersmith ,  Stephen Monfre ,  Kevin Hazen

发明人： Timothy Ruchti ,  Linda Hockersmith ,  Stephen Monfre ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  G01N21/359

摘要： The invention relates to noninvasive analyte property determination. More particularly, the invention relates to a method and apparatus for performing conditional additional acquisition of noninvasive spectra to improve analyzer performance. Conditional additional data acquisition is used to confirm, update, and/or supplement spectral data.

摘要翻译： 本发明涉及非侵入性分析物质的测定。 更具体地，本发明涉及用于执行非侵入性光谱的条件附加获取以提高分析仪性能的方法和装置。 条件附加数据采集用于确认，更新和/或补充光谱数据。

公开(公告)号：US20230240347A1

公开(公告)日：2023-08-03

申请号：US17590670

申请日：2022-02-01

申请人： Kevin Hazen ,  Mason Cave ,  Michael Roth

发明人： Kevin Hazen ,  Mason Cave ,  Michael Roth

IPC分类号： A23L29/00 ,  A23L2/54 ,  A23L2/68 ,  A23L5/40 ,  A23L2/395 ,  A23P10/28

CPC分类号： A23L29/035 ,  A23L2/54 ,  A23L2/68 ,  A23L5/40 ,  A23L2/395 ,  A23P10/28

摘要： The invention comprises an apparatus, comprising: (1) a dissolvable tablet, comprising: a support matrix, the support matrix comprising at least two percent by mass a gassing agent, the gassing agent comprising at least one of: a carbonic acid, H2CO3; a bicarbonate, HCO3; a bicarbonate salt; a carbonate, CO32−; and a carbonate salt; and (2) at least one milligram of tetrahydrocannabinol, where the dissolvable tablet optionally includes an acid and a buffer at least partially separating the gassing agent and the acid, where the tetrahydrocannabinol is blended into the support matrix of the dissolvable tablet prior to formation of the dissolvable tablet and/or is infused into a pre-made tablet comprising the support matrix.

公开(公告)号：US11678819B2

公开(公告)日：2023-06-20

申请号：US16667020

申请日：2019-10-29

申请人： Roxanne Abul-Haj ,  Kevin Hazen ,  Christopher Slawinski ,  Alan Abul-Haj

发明人： Roxanne Abul-Haj ,  Kevin Hazen ,  Christopher Slawinski ,  Alan Abul-Haj

IPC分类号： A61B5/145 ,  G01N21/359 ,  A61B5/1455 ,  A61B5/00 ,  G01N21/47 ,  G01N21/17 ,  G01N21/49

CPC分类号： A61B5/14532 ,  A61B5/0051 ,  A61B5/1455 ,  A61B5/6841 ,  G01N21/1717 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49 ,  G01N2021/1729

摘要： The invention comprises an applied force-optic analyzer used to determine a sample constituent concentration, a physical measure of the sample, and/or a state of the sample. The analyzer comprises: an electro-mechanical transducer affixed to skin of a subject; a controller, the controller providing a voltage waveform to the electro-mechanical transducer driving displacement of the skin and inducing a pressure wave into the skin; and a spectrometer interfaced to a sample site of the skin, the spectrometer comprising a set of sources and a set of detectors, where the controller is configured to collect signal from the set of detectors as a function of timing of the voltage waveform and apply a calibration model to the signal to determine the analyte concentration.

公开(公告)号：US20220129718A1

公开(公告)日：2022-04-28

申请号：US17550866

申请日：2021-12-14

申请人： Michael Roth ,  Kevin Hazen ,  Mason Cave

发明人： Michael Roth ,  Kevin Hazen ,  Mason Cave

IPC分类号： G06K19/06 ,  G06K19/077 ,  G06Q30/06 ,  G06Q10/08 ,  G08B13/24 ,  A23L2/38 ,  A23L33/105 ,  G09F3/00

摘要： The invention comprises a method and/or an apparatus for operating a Cannabis facility generating a tetrahydrocannabinol (THC) containing product, comprising the step of labeling the THC containing product with a matrix bar code/quick response (QR) code, the cannabis containing product comprising at least two milligrams of a tetrahydrocannabinol substance, the QR code linking to product information associated with the THC containing product, the product information comprising at least one of a location, date of harvest, strain, and/or type of a plant containing a tetrahydrocannabinol substance in the THC containing product; an extraction method; a date and/or a location of manufacture of the THC product; a related laboratory report; and/or a link to a related web page.