公开(公告)号：US4549152A

公开(公告)日：1985-10-22

申请号：US479452

申请日：1983-03-28

Applicant: Mahesh Kumar

Inventor： Mahesh Kumar

IPC: H03C3/00 ,  H03C7/02

CPC classification number: H03C7/02

Abstract: A phase modulation circuit to provide at an output terminal an output signal controllably shifted from 0.degree. to 360.degree. relative to an input signal provided at an input terminal includes a first 90.degree. coupler connected between the input terminal and second and third 90.degree. couplers, four gain controllable amplifiers, fourth and fifth 90.degree. couplers and an in phase combiner with its output connected to the output terminal. Two of the amplifiers are connected between the second and fourth couplers. The additional amplifiers are connected between the third and fifth couplers. The fourth and fifth couplers are connected to the inputs of the in-phase combiner. The gain through the various amplifiers is adjusted to control the amount of phase shift through the circuit.

Abstract translation: 在输出端提供相对于在输入端设置的输入信号可控地从0度向360度偏移的输出信号的相位调制电路包括连接在输入端和第二和第三和第三90度耦合器之间的第一90度耦合器， 四个增益可控放大器，第四和第五个90度耦合器和一个同相组合器，其输出端连接到输出端子。 两个放大器连接在第二和第四耦合器之间。 附加放大器连接在第三和第五耦合器之间。 第四和第五耦合器连接到同相组合器的输入端。 调整通过各种放大器的增益来控制通过电路的相移量。

公开(公告)号：US4465980A

公开(公告)日：1984-08-14

申请号：US422449

申请日：1982-09-23

Applicant: Ho-Chung Huang ,  Mahesh Kumar ,  Franco N. Sechi

Inventor： Ho-Chung Huang ,  Mahesh Kumar ,  Franco N. Sechi

IPC: H03F1/32

CPC classification number: H03F1/3205 ,  H03F1/3241

Abstract: A predistortion circuit for a radio frequency power amplifier which has gain and phase shift characteristics that are non-linear as a function of power level of an RF input signal. The circuit includes a dual gate FET, with a drain coupled to the power amplifier. A modulated RF input signal is applied to an inductive matching network which is coupled to the signal gate of the FET. A modulating envelope detected version of the input signal is applied to a video amplifier which is coupled to the FET control gate. The signal applied to the control gate varies the gain of the FET as a function of input signal to compensate for the non-linear gain characteristic of the power amplifier and in conjunction with the matching network causes a phase change of the signal through the predistortion circuit to compensate for the non-linear phase characteristic of the power amplifier.

Abstract translation: 一种用于射频功率放大器的预失真电路，其具有作为RF输入信号的功率电平的函数的非线性的增益和相移特性。 该电路包括双栅极FET，其中漏极耦合到功率放大器。 调制的RF输入信号被施加到耦合到FET的信号栅极的感应匹配网络。 将输入信号的调制包络检测版本应用于耦合到FET控制栅极的视频放大器。 施加到控制栅极的信号根据输入信号改变FET的增益，以补偿功率放大器的非线性增益特性，并且与匹配网络一起引起信号通过预失真电路的相位变化 以补偿功率放大器的非线性相位特性。

公开(公告)号：US4439744A

公开(公告)日：1984-03-27

申请号：US334258

申请日：1981-12-24

Applicant: Mahesh Kumar ,  Lakshminarasimha C. Upadhyayula

Inventor： Mahesh Kumar ,  Lakshminarasimha C. Upadhyayula

IPC: H03F1/02 ,  H03F3/21 ,  H03F3/60 ,  H03F3/72 ,  H03G3/20

CPC classification number: H03F3/211 ,  H03F1/0277 ,  H03F3/604 ,  H03F3/72

Abstract: A plurality of FET or other amplifiers are connected between respective outputs of an N output port power divider network and respective inputs of an N input power combining network in a variable power amplifier system. A gate bias is selectively supplied to each of the amplifiers which is either at a first value to cause the amplifier to amplify or at a second value to cause the amplifier to be cut off and therefore to not dissipate any DC power. The number of amplifiers receiving the first potential is determinative of the amount of power amplification of the variable power amplifier.

Abstract translation: 多个FET或其他放大器连接在N个输出端口功率分配器网络的相应输出端和可变功率放大器系统中的N个输入功率组合网络的相应输入端。 选择性地将栅极偏置提供给放大器的每个放大器，该放大器处于第一值以使放大器放大或第二值，以使放大器被切断，因此不会消散任何直流电力。 接收第一电位的放大器的数量决定了可变功率放大器的功率放大量。

公开(公告)号：US20130332597A1

公开(公告)日：2013-12-12

申请号：US13493694

申请日：2012-06-11

Applicant: Mahesh Kumar

Inventor： Mahesh Kumar

IPC: G06F15/173

CPC classification number: H04L67/1008 ,  H04L41/0896 ,  H04L61/1511 ,  H04L67/1029

Abstract: Methods and systems are provided for global server load balancing in a communication network using a global site selector and an application control engine in communication with the global site selector, in which the application control engine notifies the global site selector in response to a state change for a virtual internet protocol (VIP) address. Keepalive methods generally rely on periodically polling VIP addresses to check whether they are in an ONLINE or OFFLINE state. A minimum interval between two keepalives can be as long as 40 seconds, during which, without a mechanism to reflect state change to the load balancer in real time, if a VIP address changes state (e.g., VIP address failure), a customer can experience network outage during the time interval. Embodiments provide a mechanism to reflect, in real time, the current VIP address state to a global server load balancer to reduce failure detection time.

Abstract translation: 提供了在通信网络中使用全局站点选择器和与全球站点选择器通信的应用控制引擎的全局服务器负载平衡的方法和系统，其中应用控制引擎响应于全局站点选择器响应于 虚拟互联网协议（VIP）地址。 Keepalive方法通常依赖于定期轮询VIP地址来检查它们是处于在线还是脱机状态。 两个keepalive之间的最小间隔可以长达40秒，在此期间，如果VIP地址更改状态（如VIP地址失败），则无需实时反映负载均衡器的状态更改，客户可以体验 网络中断时间间隔。 实施例提供了一种将全局服务器负载平衡器当前的VIP地址状态实时反映以减少故障检测时间的机制。

公开(公告)号：US08323658B2

公开(公告)日：2012-12-04

申请号：US12914591

申请日：2010-10-28

Applicant: Jeffrey Harold Rodenberg ,  Mahesh Kumar ,  Kalen Cookson

Inventor： Jeffrey Harold Rodenberg ,  Mahesh Kumar ,  Kalen Cookson

IPC: A61K39/12 ,  A61K39/295 ,  C07K14/08 ,  C12N7/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2720/12022 ,  C12N2720/12034

Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.

Abstract translation: 用于传染性法氏囊病病毒的抗原分离物和疫苗包括IBDV分离株的分子6族家族的变体，特别是28-1分离株。

公开(公告)号：US08067013B2

公开(公告)日：2011-11-29

申请号：US11244574

申请日：2005-10-06

Applicant: Juan Plana-Duran ,  Rut Vila-Quintana ,  Jordi Tarres-Call ,  Mahesh Kumar

Inventor： Juan Plana-Duran ,  Rut Vila-Quintana ,  Jordi Tarres-Call ,  Mahesh Kumar

IPC: A61K39/145 ,  A61K39/295

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2760/16134

Abstract: A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined haemoagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.

Abstract translation: 本文阐述了有效预防或改善禽流感病毒感染的疫苗组合物和方法。 该疫苗含有至少两种灭活的禽流感病毒株，其中总共结合的血凝素（HA）为疫苗组合物的至少约200HA /剂量，并且其中每种菌株呈现至少约128HA /剂量，以及 其中所述菌株之一具有与攻击病毒相同的HA亚型，并且其中所述菌株中的至少一个具有与所述攻击病毒不同的NA亚型。

公开(公告)号：US20110189099A1

公开(公告)日：2011-08-04

申请号：US13071601

申请日：2011-03-25

Applicant: Mahesh Kumar ,  Muhammad Ayub Khan

Inventor： Mahesh Kumar ,  Muhammad Ayub Khan

IPC: A61K49/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/569

CPC classification number: C12N1/36 ,  A61K39/0241 ,  A61K2039/522 ,  A61K2039/552 ,  C12N1/20 ,  C12R1/35

Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.

Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质​​的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中

公开(公告)号：US20090068231A1

公开(公告)日：2009-03-12

申请号：US12207698

申请日：2008-09-10

Applicant: Mahesh Kumar ,  Muhammad Ayub Khan

Inventor： Mahesh Kumar ,  Muhammad Ayub Khan

IPC: A61K39/04 ,  C12N1/20 ,  C12Q1/32 ,  C12Q1/26 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: A61K39/0241 ,  A61K2039/522 ,  G01N33/56933 ,  G01N33/6803 ,  G01N2333/30

Abstract: The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuated Mycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.

Abstract translation: 本发明提供了活的减毒支原体细菌，相对于野生型，表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质​​的表达 相同物种的支原体细菌 还提供了涉及使用活的，减毒的支原体细菌的疫苗和疫苗接种方法，以及用于制造活的减毒支原体细菌的方法。

公开(公告)号：US20080241192A1

公开(公告)日：2008-10-02

申请号：US12079117

申请日：2008-03-25

Applicant: Mahesh Kumar ,  Christine Anschutz ,  Jean Q. Tian

Inventor： Mahesh Kumar ,  Christine Anschutz ,  Jean Q. Tian

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/552

Abstract: The present invention provides methods for inducing cross-protective immunity against virulent strains of P. multocida in animals such as cattle and poultry. The methods of the invention include administering to an animal a mutant P. multocida strain, whereby the mutant P. multocida strain induces cross-protective immunity against one or more virulent P. multocida strains having serotypes that are different from the serotype of the mutant P. multocida strain. The mutant P. multocida strain will preferably contain one or more mutations that cause the cells to be acapsular and/or attenuated. Exemplary mutations include, e.g., mutations that impair the expression of one or more genes in the P. multocida capsule biosynthetic operon (e.g., phyB, phyA, hyaE, hyaD, hyaC, hyaB, hexD, hexC, hexB, and/or hexA).

Abstract translation: 本发明提供了在动物如牛和家禽中诱导针对多杀巴斯德氏体毒性毒株的交叉保护性免疫的方法。 本发明的方法包括对动物施用突变体多杀巴斯氏杆菌菌株，其中突变体多杀巴斯德氏杆菌菌株对具有不同于突变体P的血清型的血清型的一种或多种毒力多杀巴氏杆菌菌株诱导交叉保护性免疫 多毛菌株。 突变体多杀巴斯德氏菌菌株将优选含有一种或多种导致细胞被囊泡和/或减毒的突变。 示例性的突变包括，例如，损害多球梭菌（Multocida）胶囊生物合成操纵子（例如phyB，phyA，hyaE，hyaD，hyaC，hyaB，hexD，hexC，hexB和/或hexA）中一个或多个基因表达的突变 。

公开(公告)号：US20080118531A1

公开(公告)日：2008-05-22

申请号：US11737104

申请日：2007-04-18

Applicant: Erich Hoffmann ,  Scott L. Krauss ,  Mahesh Kumar ,  Richard J. Webby ,  Robert G. Webster

Inventor： Erich Hoffmann ,  Scott L. Krauss ,  Mahesh Kumar ,  Richard J. Webby ,  Robert G. Webster

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K35/12 ,  A61K39/12 ,  A61K39/39 ,  A61K49/0004 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16134

Abstract: A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined hemagglutinin (HA) total is at least about 200 HA/dose of the vaccine composition, and wherein each of the strains presents at least about 128 HA/dose, and further wherein one of the strains has the same HA subtype as that of a challenge virus, and wherein at least one of the strains has a different NA subtype than the challenge virus.

Abstract translation: 本文阐述了有效预防或改善禽流感病毒感染的疫苗组合物和方法。 该疫苗含有至少两种灭活的禽流感病毒株，其中合并的血凝素（HA）总量为疫苗组合物的至少约200HA /剂量，并且其中每种菌株呈现至少约128HA /剂量，和 其中所述菌株之一具有与攻击病毒相同的HA亚型，并且其中所述菌株中的至少一个具有与所述攻击病毒不同的NA亚型。