公开(公告)号：US09750438B2

公开(公告)日：2017-09-05

申请号：US14015831

申请日：2013-08-30

Applicant: University of Virginia Patent Foundation

Inventor： Boris P. Kovatchev ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61M31/00 ,  A61B5/145 ,  A61B5/00 ,  A61M5/172 ,  G06F19/00

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/4839 ,  A61B5/7275 ,  A61B5/746 ,  A61M5/1723 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06F19/3468 ,  G16H40/63 ,  G16H50/50

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US12266436B2

公开(公告)日：2025-04-01

申请号：US17339153

申请日：2021-06-04

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Stephen D. Patek ,  Boris P. Kovatchev ,  Colleen H. Karvetski

IPC: G16H20/17 ,  A61M5/168 ,  G01N33/74

Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.

公开(公告)号：US11951278B2

公开(公告)日：2024-04-09

申请号：US17694870

申请日：2022-03-15

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Stephen D. Patek ,  Boris P. Kovatchev

IPC: A61M5/142 ,  A61B5/00 ,  A61B5/145 ,  A61M5/168 ,  A61M5/172 ,  G16H10/65 ,  G16H20/17 ,  G16H40/60 ,  G16H40/63 ,  G16H50/20

CPC classification number: A61M5/142 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/7275 ,  A61B5/746 ,  A61M5/168 ,  A61M5/172 ,  A61M5/1723 ,  G16H10/65 ,  G16H20/17 ,  G16H40/60 ,  G16H40/63 ,  G16H50/20 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3576 ,  A61M2205/502 ,  A61M2205/507

Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.

公开(公告)号：US11842817B2

公开(公告)日：2023-12-12

申请号：US16451766

申请日：2019-06-25

Applicant: University of Virginia Patent Foundation

Inventor： Boris P. Kovatchev ,  Marc D. Breton

IPC: G16H50/50 ,  G16H50/20 ,  G16H10/00 ,  G16B5/00 ,  G01N33/487 ,  A61B5/00 ,  A61B5/145

CPC classification number: G16H50/50 ,  A61B5/14532 ,  A61B5/7267 ,  G01N33/48707 ,  G16B5/00 ,  G16H10/00 ,  G16H50/20 ,  A61B5/4839 ,  A61B2560/0223 ,  G01N2800/042

Abstract: A method, system and computer readable medium for tracking changes in average glycemia in diabetes is based on a conceptually new approach to the retrieval of SMBG data. Using the understanding of HbA1c fluctuation as the measurable effect of the action of an underlying dynamical system, SMBG provides occasional glimpses at the state of this system and, using these measurements, the hidden underlying system trajectory can be reconstructed for individual diabetes patients. Using compartmental modeling a new two-step algorithm is provided that includes: (i) real-time estimate of HbA1c from fasting glucose readings, updated with any new incoming fasting SMBG data point(s), and (ii) initialization and calibration of the estimated HbA1c trace with daily SMBG profiles obtained periodically. The estimation of these profiles includes a factorial model capturing daily BG variability within two latent factors.

公开(公告)号：US11289201B2

公开(公告)日：2022-03-29

申请号：US15958257

申请日：2018-04-20

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. Breton ,  Boris P. Kovatchev

IPC: G08B21/04 ,  G16H50/20 ,  A61B5/145 ,  A61B5/00 ,  G16H50/30 ,  A61B5/11 ,  A61M5/172 ,  G06N7/00

Abstract: A system, method and non-transient computer readable medium for tracking hypoglycemia risk in patients with diabetes exercise. A system may include a digital processor configured to execute instructions to receive an input from each available data source of a plurality of intermittently available data sources; determine a plurality of probability signals for impending hypoglycemia, wherein each probability signal is based on one or more of the inputs from the available data sources or a lack of input from an unavailable data source; wherein a probability signal for each unavailable data source is assigned a value corresponding to a zone of uncertainty; and determine an aggregate risk of hypoglycemia based on the plurality of intermittently data sources by aggregating the plurality of probability signals.

公开(公告)号：US20210038132A1

公开(公告)日：2021-02-11

申请号：US17070245

申请日：2020-10-14

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. Kovatchev ,  Marc D. BRETON ,  Stephen D. PATEK

IPC: A61B5/145 ,  G16H50/50 ,  A61B5/00 ,  G16H20/17 ,  A61M5/172 ,  G16H40/63

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

公开(公告)号：US10903914B2

公开(公告)日：2021-01-26

申请号：US15866384

申请日：2018-01-09

Applicant: ABBOTT DIABETES CARE INC. ,  UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

IPC: H04B17/00 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  G06F19/00 ,  G16H40/67 ,  G16H10/40

Abstract: Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.

公开(公告)号：US10438700B2

公开(公告)日：2019-10-08

申请号：US14419375

申请日：2013-08-05

Applicant: University of Virginia Patent Foundation

Inventor： Edward A. Ortiz ,  Stephen D. Patek ,  Marc D. Breton ,  Leon S. Farhi ,  Boris P. Kovatchev

IPC: G01N33/48 ,  G16H50/50 ,  C12Q1/54

Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.

公开(公告)号：US10169544B2

公开(公告)日：2019-01-01

申请号：US14902731

申请日：2014-07-03

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. Breton ,  Boris P. Kovatchev ,  Chiara Dalla Man ,  Claudio Cobelli ,  Francesco Micheletto

IPC: G06F19/00 ,  G16H50/50

Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.

公开(公告)号：US20160171183A1

公开(公告)日：2016-06-16

申请号：US14902731

申请日：2014-07-03

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Boris P. Kovatchev ,  Chiara Dalla Man ,  Claudio Cobelli ,  Francesco Micheletto

IPC: G06F19/00

CPC classification number: G06F19/702 ,  G06F19/00 ,  G16H50/50

Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.

Abstract translation: 用于1型糖尿病患者电脑测试的模拟器使用将血浆浓度（即葡萄糖G和胰岛素/）与葡萄糖通量（即内源性葡萄糖产生量（EGP），外观葡萄糖率（Ra））， 通过组织（U），肾提取（E）和胰岛素通量的葡萄糖利用率，即皮下组织（SC）和胰岛素降解（D）的胰岛素出现率。 还包括一个模块来描述反调节，即胰高血糖素的动力学，分泌和作用。 胰高血糖素皮下吸收模型可以模拟双重激素控制。