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公开(公告)号：US10442791B2
公开(公告)日：2019-10-15
申请号：US15860304
申请日：2018-01-02
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D417/04 , C07D495/04 , C07D403/10 , C07D239/42 , C07D401/12 , C07D521/00 , C07D413/14 , C07D417/14 , C07D491/048 , C07D405/14 , C07D413/04 , C07D403/12 , C07D471/04 , C07D409/04 , C07D413/10 , C07D403/14 , C07D403/04 , C07D491/056 , C07D409/14 , C07D401/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20190290654A1
公开(公告)日：2019-09-26
申请号：US16372080
申请日：2019-04-01
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180311254A1
公开(公告)日：2018-11-01
申请号：US15965489
申请日：2018-04-27
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20170258789A1
公开(公告)日：2017-09-14
申请号：US15426150
申请日：2017-02-07
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , C07D401/14 , A61K31/5377
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09296701B2
公开(公告)日：2016-03-29
申请号：US13868703
申请日：2013-04-23
发明人： Paul S Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D405/14 , C07D401/04 , C07D401/14 , C07D413/04 , C07D403/04 , C07D239/02 , C07D239/42 , A61K47/48 , C07D413/14 , C07D403/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作DNA-PK抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20140045869A1
公开(公告)日：2014-02-13
申请号：US14056560
申请日：2013-10-17
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D491/048 , C07D471/04 , C07D401/12 , C07D401/14
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20130281431A1
公开(公告)日：2013-10-24
申请号：US13868703
申请日：2013-04-23
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K47/48
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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