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41 条记录 (耗时 0.065 秒)

    Ion beam profile scanner having symmetric detector surface to minimize capacitance noise
    31.
    发明授权
    Ion beam profile scanner having symmetric detector surface to minimize capacitance noise 失效
    具有对称检测器表面的离子束轮廓扫描器，以最小化电容噪声

    公开(公告)号：US4878014A

    公开(公告)日：1989-10-31

    申请号：US239454

    申请日：1988-09-01

    申请人： Michael L. Simpson

    发明人： Michael L. Simpson

    IPC分类号： G01T1/29

    CPC分类号： G01T1/29

    摘要： A beam profile scanner includes a probe constructed of a material that will emit electrons when struck by a particle beam such as an ion beam. The probe is passed through the ion beam and the electrons emitted by the probe are detected when they strike a detector surface that is configured and oriented to offer a substantially symmetric view to the moving probe in order to minimize changing capacitance noise. The detector surface is electrically connected to an analyzer circuit that monitors and further processes the current caused by electrons striking the dectector surface and that generates a signal corresponding to the ion beam profile. In the preferred embodiment, the detector surface is a circular metal plate charged to attract electrons emitted by the probe, and the symmetric view of the surface with respect to the probe helps to maintain noise at an acceptably low level. Also, preferably, a preamplifier is connected to and mounted proximate to the detector surface in a vacuum within a detector housing, and both the detector surface, amplifier and probe are disposed inside a grounded shield structure.

    摘要翻译： 光束轮廓扫描器包括由当由诸如离子束的粒子束撞击时将发射电子的材料构成的探针。 探针通过离子束，并且当探针被击穿检测器表面时，探测器发射的电子被检测，该检测器表面被构造和定向以提供对移动探针的基本对称的视图，以便最小化变化的电容噪声。 检测器表面电连接到分析器电路，该分析器电路监测并进一步处理由电子撞击检测器表面引起的电流，并产生对应于离子束分布的信号。 在优选实施例中，检测器表面是被充电以吸引由探针发射的电子的圆形金属板，并且相对于探针的表面的对称视图有助于将噪声保持在可接受的低水平。 此外，优选地，在检测器壳体内的真空中，前置放大器连接到检测器表面附近并安装在检测器表面附近，并且检测器表面，放大器和探针都设置在接地屏蔽结构内。

    Bag support means
    32.
    发明授权
    Bag support means 失效
    袋支持手段

    公开(公告)号：US4307861A

    公开(公告)日：1981-12-29

    申请号：US162572

    申请日：1980-06-24

    申请人： Ralph E. Simpson ,  Michael L. Simpson

    发明人： Ralph E. Simpson ,  Michael L. Simpson

    IPC分类号： B65B67/12 ,  A63B55/04

    CPC分类号： B65B67/1205

    摘要： A lightweight, collapsible frame for holding a plastic trash bag upright to receive trash. The frame includes a triangular base formed from three pivoted strips that can be folded together for storage when not in use. Additionally, the frame includes three tubular posts or props which are removably attachable to the corners of the triangular base in such a way as to stand upright around the space above the base. Each of the tubular posts has a crosspiece fitted to its upper end for pivotal movement between a first position crosswise of the post, where it serves to prop up the wall of a trash bag in the space above the base when the top of the bag is folded down over it, and a second position at right angles to the first for easy packing and storage purposes. A spring clip is fastened to each of the tubular posts near its upper end. A trash bag is attached to the frame for use by placing it in the space separating the upright posts above the base, with its bottom end down; folding its top edge outwardly over the crosspieces on the posts (after each has been placed in the crosswise position mentioned above) far enough to reach the spring clips on the posts; and securing the edge of the bag in the spring clips. The bag is now ready to receive trash.

    摘要翻译： 一个轻便的，可折叠的框架，用于保持塑料垃圾袋直立收集垃圾。 框架包括由三个枢轴带形成的三角形基座，当不使用时，可以将其折叠在一起用于存储。 此外，框架包括三个管状柱或道具，其可拆卸地附接到三角形底座的角部，以便围绕基座上方的空间直立。 每个管状柱具有安装在其上端的横档，用于在柱的横向的第一位置之间的枢转运动，其中，当袋的顶部是袋的顶部时，其用于支撑在基座上方的空间中的垃圾袋的壁 折叠在其上，第二位置与第一位置成直角，以方便包装和存储目的。 弹簧夹固定在靠近其上端的每个管状柱上。 垃圾袋通过将其放置在分离基座上方的立柱的空间中而附接到框架上，其底端向下; 将其顶部边缘向外折叠在柱上的横梁上（在每个已经被放置在上述横向位置之后）足够远以到达柱上的弹簧夹; 并将袋的边缘固定在弹簧夹中。 这个包现在准备好收到垃圾。

    In vivo biosensor apparatus and method of use
    36.
    发明授权
    In vivo biosensor apparatus and method of use 失效
    体内生物传感器装置及其使用方法

    公开(公告)号：US06673596B1

    公开(公告)日：2004-01-06

    申请号：US09454071

    申请日：1999-12-02

    申请人： Gary S. Sayler ,  Michael L. Simpson ,  Bruce M. Applegate ,  Steven A. Ripp

    发明人： Gary S. Sayler ,  Michael L. Simpson ,  Bruce M. Applegate ,  Steven A. Ripp

    IPC分类号： C12M300

    CPC分类号： C12Q1/02 ,  A61B5/0031 ,  C12Q1/66 ,  G01N21/763 ,  G01N33/74 ,  G01N33/84 ,  Y10S435/808 ,  Y10S435/849 ,  Y10S435/879 ,  Y10S435/909 ,  Y10S436/805

    摘要： Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in reponse to the amount of target analyte present in the body fluids.

    摘要翻译： 公开了生物发光生物循环器集成电路器件，其在植入动物身体时检测流体中的选定分析物。 该装置包括已被遗传工程化以包含核酸片段的生物携带者，所述核酸片段包含顺序激活响应元件，所述顺式活化响应元件可操作地连接到编码生物发光报告多肽的基因的选定物质。 在优选的实施方案中，目标分析物是葡萄糖，胰高血糖素或胰岛素。 将生物携带者暴露于目标物质导致响应元件上调编码报道多肽的核酸序列以产生检测和定量的发光反应。 在示例性实施例中，生物传送器装置封装在能够检测发射光，处理所得信号，然后远程报告结果的集成电路上。 还公开了能够由检测装置直接或间接控制的受控药物递送系统，所述检测装置响应于体液中存在的目标分析物的量，向动物提供诸如胰岛素的药物。

    Simultaneous CT and SPECT tomography using CZT detectors
    37.
    发明授权
    Simultaneous CT and SPECT tomography using CZT detectors 失效
    使用CZT检测器的同时CT和SPECT断层扫描

    公开(公告)号：US06399951B1

    公开(公告)日：2002-06-04

    申请号：US09496880

    申请日：2000-02-02

    申请人： Michael J. Paulus ,  Hamed Sari-Sarraf ,  Michael L. Simpson ,  Charles L. Britton, Jr.

    发明人： Michael J. Paulus ,  Hamed Sari-Sarraf ,  Michael L. Simpson ,  Charles L. Britton, Jr.

    IPC分类号： G01T1161

    CPC分类号： A61B6/482 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4035 ,  A61B6/4092 ,  A61B6/4241 ,  A61B6/4417 ,  A61B6/508 ,  A61B6/5235 ,  G01T1/1648

    摘要： A method for simultaneous transmission x-ray computed tomography (CT) and single photon emission tomography (SPECT) comprises the steps of: injecting a subject with a tracer compound tagged with a &ggr;-ray emitting nuclide; directing an x-ray source toward the subject; rotating the x-ray source around the subject; emitting x-rays during the rotating step; rotating a cadmium zinc telluride (CZT) two-sided detector on an opposite side of the subject from the source; simultaneously detecting the position and energy of each pulsed x-ray and each emitted &ggr;-ray captured by the CZT detector; recording data for each position and each energy of each the captured x-ray and &ggr;-ray; and, creating CT and SPECT images from the recorded data. The transmitted energy levels of the x-rays lower are biased lower than energy levels of the &ggr;-rays. The x-ray source is operated in a continuous mode. The method can be implemented at ambient temperatures.

    摘要翻译： 用于同时透射x射线计算机断层摄影（CT）和单光子发射断层摄影（SPECT）的方法包括以下步骤：用标有伽马射线放射核素的示踪剂化合物注射受试者; 将x射线源引导到受试者; 围绕主体旋转x射线源; 在旋转步骤期间发射X射线; 在来自对象的另一侧旋转碲化锌碲化镉（CZT）双面检测器; 同时检测每个脉冲X射线的位置和能量以及由CZT检测器捕获的每个发射的γ射线; 记录每个位置的数据和每个捕获的X射线和γ射线的每个能量; 并从记录的数据创建CT和SPECT图像。 x射线的透射能级低于伽马射线的能级。 x射线源以连续模式运行。 该方法可以在环境温度下实现。

    Integrated CMOS spectrometers
    39.
    发明授权
    Integrated CMOS spectrometers 失效
    集成CMOS光谱仪

    公开(公告)号：US5965873A

    公开(公告)日：1999-10-12

    申请号：US82082

    申请日：1998-05-20

    申请人： Michael L. Simpson ,  M. Nance Ericson ,  William B. Dress ,  Gerald E. Jellison ,  David N. Sitter, Jr. ,  Alan L. Wintenberg

    发明人： Michael L. Simpson ,  M. Nance Ericson ,  William B. Dress ,  Gerald E. Jellison ,  David N. Sitter, Jr. ,  Alan L. Wintenberg

    IPC分类号： G01J3/02 ,  G01J3/28 ,  H01L27/12 ,  H01L27/142 ,  H01L31/0216 ,  H01L31/102 ,  H01J40/14

    CPC分类号： G01J3/02 ,  G01J3/0256 ,  G01J3/2803 ,  H01L27/1203 ,  H01L31/02165

    摘要： A spectrometer, comprises: a semiconductor having a silicon substrate, the substrate having integrally formed thereon a plurality of layers forming photo diodes, each of the photo diodes having an independent spectral response to an input spectra within a spectral range of the semiconductor and each of the photo diodes formed only from at least one of the plurality of layers of the semiconductor above the substrate; and, a signal processing circuit for modifying signals from the photo diodes with respective weights, the weighted signals being representative of a specific spectral response. The photo diodes have different junction depths and different polycrystalline silicon and oxide coverings. The signal processing circuit applies the respective weights and sums the weighted signals. In a corresponding method, a spectrometer is manufactured by manipulating only the standard masks, materials and fabrication steps of standard semiconductor processing, and integrating the spectrometer with a signal processing circuit.

    摘要翻译： 一种光谱仪，包括：具有硅衬底的半导体，所述衬底在其上整体形成有多个形成光电二极管的层，每个光电二极管对半导体的光谱范围内的输入光谱具有独立的光谱响应， 所述光电二极管仅由所述衬底上的所述半导体的多个层中的至少一个形成; 以及信号处理电路，用于用相应权重修改来自光电二极管的信号，加权信号代表特定光谱响应。 光电二极管具有不同的结深度和不同的多晶硅和氧化物覆盖层。 信号处理电路应用相应的权重并对加权信号求和。 在相应的方法中，通过仅操纵标准半导体处理的标准掩模，材料和制造步骤以及将光谱仪与信号处理电路集成来制造光谱仪。

    Virtual mask digital electron beam lithography
    40.
    发明授权
    Virtual mask digital electron beam lithography 失效
    虚拟掩模数字电子束光刻

    公开(公告)号：US5892231A

    公开(公告)日：1999-04-06

    申请号：US795003

    申请日：1997-02-05

    申请人： Larry R. Baylor ,  Clarence E. Thomas ,  Edgar Voelkl ,  James A. Moore ,  Michael L. Simpson ,  Michael J. Paulus

    发明人： Larry R. Baylor ,  Clarence E. Thomas ,  Edgar Voelkl ,  James A. Moore ,  Michael L. Simpson ,  Michael J. Paulus

    IPC分类号： G03F7/20 ,  H01J37/305 ,  H01J37/317 ,  H01L21/027 ,  H01J37/30

    CPC分类号： B82Y10/00 ,  B82Y40/00 ,  H01J37/3175 ,  H01J2237/31786

    摘要： Systems and methods for direct-to-digital holography are described. An apparatus includes a laser; a beamsplitter optically coupled to the laser; a reference beam mirror optically coupled to the beamsplitter; an object optically coupled to the beamsplitter, a focusing lens optically coupled to both the reference beam mirror and the object; and a digital recorder optically coupled to the focusing lens. A reference beam is incident upon the reference beam mirror at a non-normal angle, and the reference beam and an object beam are focused by the focusing lens at a focal plane of the digital recorder to form an image. The systems and methods provide advantages in that computer assisted holographic measurements can be made.

    摘要翻译： 描述了用于直接数字全息术的系统和方法。 一种装置包括一激光器; 与激光光学耦合的分束器; 光束耦合到分束器的参考光束镜; 光学耦合到分束器的物体，光学耦合到参考光束镜和物体的聚焦透镜; 以及光学耦合到聚焦透镜的数字记录器。 参考光束以非正常角度入射到参考光束镜上，并且参考光束和物体光束被聚焦透镜聚焦在数字记录器的焦平面处以形成图像。 该系统和方法提供了可以进行计算机辅助全息测量的优点。