公开(公告)号：US20180202983A1

公开(公告)日：2018-07-19

申请号：US15872842

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille, SR.

IPC: G01N30/88 ,  G01N30/86 ,  G01M3/20 ,  G01N30/60

CPC classification number: G01N30/88 ,  G01M3/202 ,  G01M3/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/26 ,  G01N30/6052 ,  G01N30/8675 ,  G01N2030/889

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US09929000B2

公开(公告)日：2018-03-27

申请号：US14523350

申请日：2014-10-24

Applicant: Waters Technologies Corporation

Inventor： Michael J. Tomany ,  Marc V. Gorenstein ,  Joseph A. Jarrell

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/14 ,  G01N30/72 ,  G01N33/68 ,  H01J49/04

CPC classification number: H01J49/10 ,  G01N30/72 ,  G01N30/7266 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/145 ,  Y10T436/25875

Abstract: A method of ionizing a sample includes providing an aqueous liquid and directing a jet comprising carbon dioxide to interact with the provided aqueous liquid. One or both of the aqueous liquid and the jet comprise the sample. At least a portion of the sample is ionized due to the interaction.

公开(公告)号：US09305761B2

公开(公告)日：2016-04-05

申请号：US14458311

申请日：2014-08-13

Applicant: Waters Technologies Corporation

Inventor： Joseph A. Jarrell

IPC: H01J49/16 ,  H01J49/04

CPC classification number: H01J49/16 ,  H01J49/0454

Abstract: An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream. Preferably, the droplets have a diameter that is greater than a preset value to increase the kinetic energy of the droplets. Additionally, the droplet generator can be configured to create a gas flow that increases the kinetic energy of the droplets. In one embodiment, the target is positioned upstream of an inlet of a mass spectrometer so that the ion stream enters the inlet. In another preferred embodiment, the target is positioned downstream of the inlet so that the stream of droplets passes through the inlet of the mass spectrometer, and the inlet is provided with a pressure drop that increases the kinetic energy of the droplets.

Abstract translation: 公开了用于质谱仪的离子源和离子化样品的方法。 液滴发生器被配置为发射分析物液滴流，其在与靶碰撞时被离子化，从而形成离子流。 优选地，液滴具有大于预设值的直径以增加液滴的动能。 另外，液滴发生器可以被配置成产生增加液滴动能的气流。 在一个实施方案中，靶位于质谱仪的入口的上游，使得离子流进入入口。 在另一个优选实施例中，靶位于入口的下游，使得液滴流通过质谱仪的入口，并且入口设置有增加液滴的动能的压降。