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公开(公告)号：US20110195094A1
公开(公告)日：2011-08-11
申请号：US12673254
申请日：2008-08-13
申请人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
发明人： Weiwen Ying , Lijun Sun , Keizo Koya , Dinesh U. Chimmanamada , Shijie Zhang , Teresa Kowalcyzk Przewloka , Hao Li
IPC分类号： A61K31/675 , C07F9/12 , C07D413/14 , A61P35/00 , A61P29/00 , C12N5/071 , A61P31/10 , A61P33/00 , A61P31/12 , A61P31/04 , A61P37/06 , A61P37/02
CPC分类号： A61K31/675 , C07D209/04 , C07D249/08 , C07D403/04 , C07F9/6518 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20060167070A1
公开(公告)日：2006-07-27
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D403/02 , C07D249/12 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US08415377B2
公开(公告)日：2013-04-09
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/14 , C07D403/04 , A61K31/4196 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US07662813B2
公开(公告)日：2010-02-16
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , A61K31/4025 , A61K31/4523 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D249/08 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20070155809A1
公开(公告)日：2007-07-05
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , C07D249/08 , C07D403/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20140079636A1
公开(公告)日：2014-03-20
申请号：US13843771
申请日：2013-03-15
IPC分类号： A61K47/48 , A61K31/4745 , A61K31/454 , G01N33/574 , A61K31/513 , A61K31/58 , A61K31/4184 , A61K31/704 , A61K31/4196 , A61K31/185
CPC分类号： A61K31/565 , A61K31/167 , A61K31/185 , A61K31/4184 , A61K31/4196 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/58 , A61K31/704 , A61K47/54 , A61K47/545 , A61K47/55 , A61P35/00 , G01N33/574 , G01N33/57496
摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to an binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
摘要翻译： 本发明提供了药理化合物，其包括与将效应子部分指向感兴趣的生物靶标的结合部分缀合的效应子部分。 同样，本发明提供包括化合物的组合物，试剂盒和方法（例如治疗，诊断和成像）。 该化合物可被描述为蛋白质相互作用结合部分 - 药物偶联物（SDC-TRAP）化合物，其包括蛋白质相互作用结合部分和效应部分。 例如，在针对治疗癌症的某些实施方案中，SDC-TRAP可包括与细胞毒性剂缀合的Hsp90抑制剂作为效应部分。
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公开(公告)号：US20110144103A1
公开(公告)日：2011-06-16
申请号：US12995714
申请日：2009-06-04
IPC分类号： A61K31/5377 , C07D413/14 , C07D207/34 , C07D403/10 , C07D413/10 , C07D413/12 , C07D405/10 , C07D403/14 , C07D405/14 , A61K31/40 , A61K31/496 , A61K31/4025 , A61K31/454 , A61P35/00
CPC分类号： C07D207/34 , A61K31/40 , C07D207/335 , C07D405/06 , C07D405/14
摘要： The present invention relates to substituted pyrrole compounds and compositions comprising substituted pyrrole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted pyrrole compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译： 本发明涉及取代的吡咯化合物和包含取代的吡咯化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的吡咯化合物或 包含这种化合物的药物组合物。
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公开(公告)号：US20170056510A1
公开(公告)日：2017-03-02
申请号：US14917387
申请日：2016-03-08
申请人： Dinesh U. Chimmanamada , Weiwen Ying , Junyi Zhang , Teresa Kowalczyk-Przewloka , Jun Jiang , Sami Osman , Genliang Lu , Dharma Vutukuri , James Loch , Shoujun Chen
发明人： Dinesh U. Chimmanamada , Weiwen Ying , Junyi Zhang , Teresa Kowalczyk-Przewloka , Jun Jiang , Sami Osman , Genliang Lu , Dharma Vutukuri , James Loch , Shoujun Chen
IPC分类号： A61K47/48 , A61K31/454 , A61K31/519 , A61K31/513 , A61K31/4184 , A61K31/167 , A61K31/58 , A61K31/4545 , A61K31/704 , A61K31/497 , A61K31/42 , A61K31/4188 , A61K31/495 , A61K31/506 , A61K31/565 , A61K38/05 , A61K31/4745
摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
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公开(公告)号：US20130261164A1
公开(公告)日：2013-10-03
申请号：US13902290
申请日：2013-05-24
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , A61K31/40 , C07D207/335 , C07D405/06 , C07D405/14
摘要： The present invention relates to substituted pyrrole compounds and compositions comprising substituted pyrrole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted pyrrole compound of the invention, or a pharmaceutical composition comprising such a compound.
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公开(公告)号：US08450500B2
公开(公告)日：2013-05-28
申请号：US12995714
申请日：2009-06-04
IPC分类号： C07D207/30 , A61K31/40
CPC分类号： C07D207/34 , A61K31/40 , C07D207/335 , C07D405/06 , C07D405/14
摘要： The present invention relates to substituted pyrrole compounds and compositions comprising substituted pyrrole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted pyrrole compound of the invention, or a pharmaceutical composition comprising such a compound.
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