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公开(公告)号：US20080144912A1
公开(公告)日：2008-06-19
申请号：US11833417
申请日：2007-08-03
申请人： Raulf M. Polichar , Gary M. Rush , Scott T. Smith
发明人： Raulf M. Polichar , Gary M. Rush , Scott T. Smith
IPC分类号： G06K9/00
CPC分类号： G01V5/0008
摘要： Digital pixel data is obtained from radiographic imaging of one or more objects, and corresponds to an imaged area containing a feature to be measured. A data profile for a region around the measured feature is created from the digital pixel data. A reference profile is then created from the data profile. The reference profile represents an expected data profile for a reference condition of the objects, and accounts for the point spread function of the imager. The difference between the data profile and the reference profile is calculated. Based on that difference, the degree by which the actual condition of the objects varies from the reference condition is determined. The calculated difference can be compared to a lookup table mapping previously calculated differences to degrees of variation from the reference condition. The calculated difference can also be used as an input to an experimentally derived formula.
摘要翻译： 从一个或多个物体的放射成像获得数字像素数据，并且对应于包含要测量的特征的成像区域。 从数字像素数据创建测量特征周围区域的数据轮廓。 然后从数据配置文件创建参考配置文件。 参考文件表示对象的参考条件的预期数据简档，并考虑了成像器的点扩散功能。 计算数据配置文件和参考配置文件之间的差异。 基于该差异，确定对象的实际条件与参考条件不同的程度。 计算出的差值可以与先前计算出的差异与参考条件的变化幅度进行比较。 计算的差值也可以用作实验导出公式的输入。
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公开(公告)号：US06273851B1
公开(公告)日：2001-08-14
申请号：US09312215
申请日：1999-05-14
IPC分类号： A61M3600
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially radiotransparent cylindrical capsule containing a radioactive isotope and, in particular embodiments, a radiopaque or MRI-visible marker. Each of the embodiments is designed to provide a substantially isotropic distribution of radiation. In one embodiment, the isotope is deposited on the outer surface of a hollow radiolucent tube and a collar is provided about a central portion of the tube. The capsule comprises two tubular halves positioned over the tube with the open ends of the halves forming an interference fit with the collar and welded thereabout. In another embodiment, the isotope bearing structure is a plurality of radiolucent spheres provided with a thin coating of silver to facilitate the adhesion of the isotope thereto. The spheres are provided in two capsule halves which are welded closed about a plug have an axial radiopaque marker therein. In yet another embodiment, the isotope bearing structure is a pair of silver tubes having surfaces on which the isotope is provided. One tube is positioned in each half of the capsule, and the halves are then welded about a plug provided with a marker. In each embodiment, the closed ends of the capsule are provided with tissue engaging members or connectors which can be coupled to discrete spacing links.
摘要翻译： 放射性治疗种子包括含有放射性同位素的基本上无辐射透明的圆柱形胶囊，特别是不透射线或MRI可见标记。 每个实施例被设计成提供基本上各向同性的辐射分布。 在一个实施例中，同位素沉积在中空的射线可透管的外表面上，并且围绕管的中心部分提供轴环。 胶囊包括位于管上方的两个管状半部，其半开口端形成与套环的过盈配合并在其周围焊接。 在另一个实施方案中，同位素承载结构是多个具有薄的银涂层的射线可透过球，以便于同位素与其粘附。 球体设置在两个胶囊半部中，其围绕塞子被焊接封闭，其中具有轴向不透射线的标记。 在另一个实施方案中，同位素承载结构是具有其上提供同位素的表面的一对银管。 一个管被定位在胶囊的每一半中，然后将半部焊接在设置有标记的塞子周围。 在每个实施例中，胶囊的封闭端部设置有组织接合构件或可连接到分立间隔连接件的连接器。
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公开(公告)号：US06255654B1
公开(公告)日：2001-07-03
申请号：US09398980
申请日：1999-09-17
IPC分类号： G01N2304
CPC分类号： G01N23/02 , G01V5/0016
摘要： A system and method of density detection in a target object involve irradiating the target object, detecting a first and second discrete number of photons penetrating the target object through respective first and second prescribed volumes and entering respective first and second radiation detectors. First and second numbers of photons detected by the first and second radiation detectors are counted, and a display output signal is generated in response to the first and second numbers. A graphical representation of the densities within the first and second volumes of the target object is displayed.
摘要翻译： 目标物体中密度检测的系统和方法包括照射目标物体，通过相应的第一和第二规定体积检测穿过目标物体的第一和第二离散数量的光子并进入相应的第一和第二辐射检测器。 对由第一和第二辐射检测器检测的第一和第二数量的光子进行计数，并且响应于第一和第二数量产生显示输出信号。 显示目标对象的第一和第二卷内的密度的图形表示。
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公开(公告)号：US6080099A
公开(公告)日：2000-06-27
申请号：US133081
申请日：1998-08-12
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially cylindrical capsule containing a radioactive isotope and, preferably, a radiopaque marker. According to one embodiment, the capsule is made of titanium or stainless steel, the isotope is deposited on the surface of a hollow cylinder and a titanium or stainless steel tube is disposed inside the hollow cylinder. The capsule is sealed by swaging the end of the capsule against the inner tube and welding the swaged end and tube. The inner tube facilitates swaging and protects the contents of the capsule from the heat of welding. In alternate embodiments, a radiopaque marker is disposed inside the inner tube or the cylinder bearing the radioisotope is radiopaque. According to other embodiments, a gripping stem is installed on one or both ends of a capsule, a capsule is made of very thin material with rotary swaged ends welded shut and a supporting structure inside the capsule, a meltable isotope mixture is used to coat the interior of a capsule, a capsule is assembled from two halves which are placed over an interior tube and the halves are butt welded, a capsule is made of a borosilicate or elemental silicon glass tube with ends melted to seal the capsule. Bioabsorbable spacers are provided for use with seeds having gripping/linking stems so that seeds are linked together.
摘要翻译： 放射性治疗种子包括含有放射性同位素，优选不透射线标记物的基本上圆柱形的胶囊。 根据一个实施例，胶囊由钛或不锈钢制成，同位素沉积在中空圆柱体的表面上，钛或不锈钢管设置在中空圆柱体的内部。 通过将胶囊端部抵靠内管将模具密封，并焊接模锻端和管。 内管有助于模锻，并保护胶囊的内容物免受焊接热。 在替代实施例中，不透射线的标记设置在内管或带有放射性同位素的不透射线的气缸内。 根据其他实施例，夹持杆安装在胶囊的一端或两端，胶囊由非常薄的材料制成，其中旋转成型端部被焊接并且在胶囊内部具有支撑结构，可熔融的同位素混合物用于涂覆 胶囊的内部，由放置在内部管上的两个半部组装，并且半部对接焊接，胶囊由硼硅酸盐或元素硅玻璃管制成，端部熔化以密封胶囊。 提供生物可吸收隔离物用于具有夹持/连接茎的种子，使得种子连接在一起。
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公开(公告)号：US07924483B2
公开(公告)日：2011-04-12
申请号：US11367580
申请日：2006-03-06
申请人： Scott T. Smith , Dmitry Bakin
发明人： Scott T. Smith , Dmitry Bakin
IPC分类号： H04N1/04
CPC分类号： H04N9/093 , H01L27/14621 , H01L27/14623 , H04N5/3415
摘要： The invention, in various exemplary embodiments, incorporates multiple image sensor arrays, with separate respective color filters, on the same imager die. One exemplary embodiment is an image sensor comprising a plurality of arrays of pixel cells at a surface of a substrate, wherein each pixel cell comprises a photo-conversion device. The arrays are configured to commonly capture an image. An image processor circuit is connected to said plurality of arrays and configured to combine the captured images, captured by the plurality of arrays, and output a color image.
摘要翻译： 在各种示例性实施例中，本发明在相同的成像器模具上并入多个图像传感器阵列以及单独的各自的滤色器。 一个示例性实施例是包括在衬底的表面处的多个像素单元阵列的图像传感器，其中每个像素单元包括光转换器件。 阵列被配置为通常捕获图像。 图像处理器电路连接到所述多个阵列并且被配置为组合由多个阵列捕获的所捕获的图像，并输出彩色图像。
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36.发明授权公开(公告)号：US06796936B2
公开(公告)日：2004-09-28
申请号：US10281777
申请日：2002-10-28
IPC分类号： A61M3612
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1024
摘要： An implantable radiation therapy device includes a biocompatible radiotranslucent outer capsule containing a radiation shielding element and a radioactive isotope at least partially shielded by the shielding element. When the device is at or below body temperature, radiation is prevented or limited from being transmitted through the outer capsule by the shielding element. When non-ambient energy is applied to the device, the shielding element and radioactive isotope are reconfigured such that an increased level of radiation is transmitted through the outer capsule and emitted by the device.
摘要翻译： 可植入放射治疗装置包括生物相容的无辐射透明外胶囊，其包含至少部分被屏蔽元件屏蔽的辐射屏蔽元件和放射性同位素。 当装置处于或低于体温时，防止或限制辐射通过屏蔽元件透过外胶囊。 当非环境能量被施加到设备时，屏蔽元件和放射性同位素被重新配置，使得增加的辐射水平通过外部胶囊传输并被设备发射。
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公开(公告)号：US06264599B1
公开(公告)日：2001-07-24
申请号：US09371194
申请日：1999-08-10
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a substantially radiotransparent cylindrical capsule provided with a radioactive isotope, a radiopaque marker, and an engagement structure adapted to engage tissue surrounding the seeds at the implant site. The engagement structure is also preferably adapted to releasably engage the inside of a delivery needle prior to implantation. The engagement structure is preferably adapted to prevent axial longitudinal movement and axial rotation of a seed about its longitudinal axis when the seed is implanted. According to a preferred embodiment of the invention, the engagement structure includes three spring elements which are biased away from the seed capsule and which provide positive fixation in the tissue, and also frictionally engage the inside of the needle.
摘要翻译： 放射性治疗种子包括设置有放射性同位素，不透射线标记物和适于在植入部位接合种子周围的组织的接合结构的基本上无辐射透明的圆柱形胶囊。 接合结构还优选地适于在植入之前可释放地接合输送针的内部。 接合结构优选地适于在种子植入时防止种子围绕其纵向轴线的轴向纵向移动和轴向旋转。 根据本发明的优选实施例，接合结构包括偏离种子囊的三个弹簧元件，并且在组织中提供正的固定，并且还摩擦地接合针的内部。
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公开(公告)号：US06210316B1
公开(公告)日：2001-04-03
申请号：US09133072
申请日：1998-08-12
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： Radioactive therapeutic seeds include a seed capsule, a radioactive isotope, and a radiopaque marker. According to one embodiment of the invention, the radiopaque marker is a silver wire coil and the isotope is coated on the surface of the coil. According to a first method of the invention, the therapeutic dosage of the seed is adjusted during manufacture by expanding or contracting the coil before it sized and deposited in the capsule. According to second embodiment, the radiopaque marker is a silver rod and the isotope is coated on a radiotransparent coil which is placed over the rod. According to a third embodiment, the isotope is coated on a plurality of rings which are stacked on a radiopaque rod. According to a second method of the invention, the therapeutic dosage of the seed is adjusted during manufacture by stacking a mixture of radio-inactive rings with radioactive rings on the radiopaque rod before the capsule is sealed.
摘要翻译： 放射性治疗种子包括种子胶囊，放射性同位素和不透射线的标记。 根据本发明的一个实施例，不透射线的标记是银线盘，并且同位素涂覆在线圈的表面上。 根据本发明的第一种方法，在制造期间通过在将线圈定尺寸并沉积在胶囊中之前使线圈膨胀或收缩来调节种子的治疗剂量。 根据第二实施例，不透射线的标记是银棒，同位素涂覆在放置在杆上的无线电透射线圈上。 根据第三实施例，同位素被涂覆在堆叠在不透射线棒上的多个环上。 根据本发明的第二种方法，在制造期间通过在胶囊被密封之前将无线电非活性环与放射性环的混合物堆叠在不透射线的棒上来调节种子的治疗剂量。
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39.发明授权Portable, digital X-ray apparatus for producing, storing and displaying electronic radioscopic images 失效用于制造，存储和显示电子放射线图像的便携式数字X射线装置
公开(公告)号：US5909478A
公开(公告)日：1999-06-01
申请号：US76604
申请日：1998-05-11
申请人： Raulf M. Polichar , Scott T. Smith
发明人： Raulf M. Polichar , Scott T. Smith
CPC分类号： G01N23/04 , G01V5/0016 , G01V5/0083 , H04L67/12
摘要： A portable, self-contained, electronic radioscopic imaging system uses a pulsed X-ray source, a remote X-ray sensor, and a self-contained, display and controller unit to produce, store, and/or display digital radioscopic images of an object under investigation. The pulsed X-ray source transmits a burst of narrow pulses of X-rays at the object being investigated at a low repetition rate. The X-ray sensor utilizes an X-ray scintillating screen in combination with either an integrating CCD camera, or an active matrix of thin film transistors and sample-and-hold photodiodes, to produce an integrated signal representative of the accumulated number of flashes of radiation (X-ray pulses that pass through the object) that are sensed in a given pixel area of the scintillating screen. The self-contained display and controller unit utilizes digital signal processing within an enhanced portable computer, including a flat solid state display panel and associated drive circuitry, in order to display the full dynamic range and resolution of the sensor. A modem allows the digitized image to be sent to a remote location where the exact same image can be recreated for analysis by off-site experts.
摘要翻译： 便携式，独立的电子放射线成像系统使用脉冲X射线源，远程X射线传感器和独立的显示器和控制器单元来产生，存储和/或显示数字放射线图像 被调查对象 脉冲X射线源以低重复率在正在研究的物体上发射X射线的窄脉冲的脉冲。 X射线传感器利用X射线闪烁屏幕与积分CCD相机或薄膜晶体管的有源矩阵以及采样和保持光电二极管组合，以产生代表累积闪光次数的积分信号 在闪烁屏幕的给定像素区域中感测到的辐射（穿过物体的X射线脉冲）。 独立显示和控制器单元利用增强型便携式计算机内的数字信号处理，包括平面固态显示面板和相关联的驱动电路，以便显示传感器的全部动态范围和分辨率。 调制解调器允许将数字化图像发送到远程位置，其中可以重新创建完全相同的图像以供异地专家分析。
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