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    Stable blood coagulation inhibitor-free factor vii preparation and method for preparing same
    33.
    发明授权
    Stable blood coagulation inhibitor-free factor vii preparation and method for preparing same 有权
    稳定的凝血抑制因子制剂及其制备方法

    公开(公告)号：US06777390B1

    公开(公告)日：2004-08-17

    申请号：US09719945

    申请日：2001-02-20

    申请人： Peter Matthiessen ,  Peter Turecek ,  Hans-Peter Schwarz

    发明人： Peter Matthiessen ,  Peter Turecek ,  Hans-Peter Schwarz

    IPC分类号： A61K3800

    CPC分类号： C12N9/6437 ,  A61K38/00 ,  C12Y304/21021

    摘要： Stable pharmaceutical preparations containing blood coagulation Factor VII is disclosed. The pharmaceutical preparations containing blood coagulation Factor VII are free of coagulation inhibitors and are stable over a wide range of environmental conditions. Also provided are blood coagulation Factor VII preparations having a minimum activity of 50 Units/mg of protein that contain less than 5% activated blood coagulation Factor VII (Factor VIIa). The blood coagulation Factor VII containing preparations may also contain other blood coagulation factors and are free from detectable transmissible human pathogens.

    摘要翻译： 公开了含有凝血因子VII的稳定的药物制剂。 含有凝血因子VII的药物制剂不含凝血抑制剂，并且在宽范围的环境条件下是稳定的。 还提供具有最小活性为50单位/ mg蛋白质的含有少于5％的活化凝血因子VII（因子VIIa）的凝血因子Ⅶ制剂。 含有凝血因子Ⅶ的制剂还可含有其他凝血因子，并且不含可检测的可传播的人类病原体。

    Treatment with lys-plasminogen of reperfusion injury and brain edema caused by ischemia
    35.
    发明授权
    Treatment with lys-plasminogen of reperfusion injury and brain edema caused by ischemia 失效
    用裂解纤溶酶原的再灌注损伤治疗和脑缺血引起的脑水肿

    公开(公告)号：US5597800A

    公开(公告)日：1997-01-28

    申请号：US345468

    申请日：1994-11-21

    申请人： Johann Eibl ,  Ludwig Pichler ,  Hans-Peter Schwarz

    发明人： Johann Eibl ,  Ludwig Pichler ,  Hans-Peter Schwarz

    IPC分类号： A61K38/00 ,  A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61P9/00 ,  A61P9/10

    CPC分类号： A61K38/484 ,  Y10S514/802

    摘要： A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen alone, in a dosage of about 10-1000 caseinolytic units/kg, can be used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like. Lys-plasminogen can also lessen cerebral edema which results from cerebral ischemia.

    摘要翻译： 缺血和伴随的再灌注损伤的治疗需要施用纤溶酶和纤溶酶形成蛋白，包括溶酶原纤溶酶原和类似物质。 已经发现，可以从葡萄糖分解纤维蛋白溶酶原的蛋白水解切割中获得的Lys-plasminogen对缺血条件损伤的组织具有保护作用。 在再灌注期间和再灌注已经发生后，以约10-1000个酪蛋白分解单位/ kg的剂量单独施用lys-plasminogen可用于治疗受试者。 Lys-纤溶酶原也可以与凝块溶解疗法结合使用，例如使用组织纤溶酶原激活剂等的那些。 Lys-纤溶酶原也可以减轻由脑缺血引起的脑水肿。

    KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A SAMPLE OF A PATIENT'S BLOOD OR PLASMA
    39.
    发明申请
    KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A SAMPLE OF A PATIENT'S BLOOD OR PLASMA 有权
    用于测量患者血液或血浆样本中样品的血小板生成的试剂盒

    公开(公告)号：US20130052672A1

    公开(公告)日：2013-02-28

    申请号：US13539154

    申请日：2012-06-29

    申请人： Katalin Varadi ,  Peter Turecek ,  Brigitte Keil ,  Sylvia Peyrer-Heimstaett ,  Hans-Peter Schwarz

    发明人： Katalin Varadi ,  Peter Turecek ,  Brigitte Keil ,  Sylvia Peyrer-Heimstaett ,  Hans-Peter Schwarz

    IPC分类号： G01N21/64

    CPC分类号： A61K31/66 ,  C12Q1/56 ,  G01N33/86 ,  G01N2333/745

    摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.

    摘要翻译： 本发明提供了一种用于测量患者血液或血浆样品或凝血因子样品中的凝血酶产生的试剂盒。 该试剂盒含有冻干组织因子/磷脂复合物和含有凝血酶底物和CaCl 2的冻干混合物。 本发明还提供了用于制备试剂盒的试剂的方法。 该试剂盒可以用于测量样品中凝血酶产生的方法，其中可以检测凝血酶产生动力学的变化，例如在将抑制剂旁路剂施用于已经开发出外源凝血因子的抑制剂的患者之后 作为因子VIII。