公开(公告)号：US08774918B2

公开(公告)日：2014-07-08

申请号：US12362838

申请日：2009-01-30

申请人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

发明人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

IPC分类号： A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3621 ,  A61B5/04288 ,  A61B5/7217 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/36185 ,  A61N1/3686 ,  A61N1/3702 ,  A61N1/3706 ,  A61N1/3718 ,  A61N1/37247 ,  A61N1/37288 ,  A61N1/3962

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US08703200B2

公开(公告)日：2014-04-22

申请号：US12429650

申请日：2009-04-24

申请人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

发明人： James F. McGinnis ,  Xiaohong Zhou ,  Lily L. Wong ,  Sudipta Seal

IPC分类号： A61K9/14 ,  A01N59/16 ,  A61K33/24

CPC分类号： A61K9/14 ,  A61K33/24

摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.

摘要翻译： 本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。 本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上 在滑膜组织中 在肠组织中 或在骨头。 此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。 因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

公开(公告)号：US08688210B2

公开(公告)日：2014-04-01

申请号：US12362859

申请日：2009-01-30

申请人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  James D. Reinke

发明人： John E. Burnes ,  Paul G. Krause ,  William T. Donofrio ,  Gerald P. Arne ,  David J. Peichel ,  Xiaohong Zhou ,  James D. Reinke

IPC分类号： A61N1/08

CPC分类号： A61N1/36114 ,  A61B5/0424 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7217 ,  A61B2560/0271 ,  A61N1/36185 ,  A61N1/3622 ,  A61N1/365 ,  A61N1/3686 ,  A61N1/37247 ,  A61N1/37288 ,  A61N1/3962 ,  A61N2001/083

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

摘要翻译： 可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。 在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

公开(公告)号：US08417334B2

公开(公告)日：2013-04-09

申请号：US10039307

申请日：2001-10-26

申请人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

发明人： Michael R. S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

IPC分类号： A61N1/365

CPC分类号： A61N1/36114 ,  A61N1/3627

摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.

公开(公告)号：US20120185008A1

公开(公告)日：2012-07-19

申请号：US13353824

申请日：2012-01-19

申请人： Xiaohong Zhou ,  Robert Stadler ,  Richard Cornelussen ,  Lillian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

发明人： Xiaohong Zhou ,  Robert Stadler ,  Richard Cornelussen ,  Lillian Kornet ,  Paul D. Ziegler ,  Karen J. Kleckner ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US20120109240A1

公开(公告)日：2012-05-03

申请号：US12915877

申请日：2010-10-29

申请人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

发明人： Xiaohong Zhou ,  Robert Stadler ,  Bruce D. Gunderson ,  Walter H. Olson

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3706 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/3621

摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).

摘要翻译： 用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

公开(公告)号：US20100198308A1

公开(公告)日：2010-08-05

申请号：US12696914

申请日：2010-01-29

申请人： Xiaohong Zhou ,  William T. Donofrio ,  Paul G. Krause ,  John E. Burnes

发明人： Xiaohong Zhou ,  William T. Donofrio ,  Paul G. Krause ,  John E. Burnes

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/36135 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36592

摘要： Neurostimulation to mitigate lung wetness is delivered to a patient based on a sensed parameter indicative of lung wetness. The neurostimulation is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient. In some examples, a patient response to the neurostimulation therapy may be detected to modify the neurostimulation therapy. The patient response may include, for example, changes in the contractility of a heart of the patient, changes in the heart rate, heart rate variability or blood pressure of the patient, changes in a bladder size of the patient, changes in bladder functional activity of the patient, changes in urine flow, changes in lung function, changes in lung composition, or changes in the nerve activity of the patient.

摘要翻译： 基于指示肺湿度的感测参数将减轻肺湿润的神经刺激递送给患者。 神经刺激被配置成在患者体内增加副交感神经活动或减少交感神经活动中的至少一种。 在一些实例中，可以检测患者对神经刺激疗法的反应以修饰神经刺激疗法。 患者反应可以包括例如患者的心脏的收缩性变化，心率的改变，患者的心率变异性或血压，患者的膀胱尺寸的变化，膀胱功能活动的变化 的患者，尿流量的变化，肺功能的变化，肺组成的变化或患者的神经活动的变化。

公开(公告)号：US20100114224A1

公开(公告)日：2010-05-06

申请号：US12362822

申请日：2009-01-30

申请人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

发明人： Paul G. Krause ,  John E. Burnes ,  William T. Donofrio ,  David J. Peichel ,  Gerald P. Arne ,  Xiaohong Zhou ,  James D. Reinke

IPC分类号： A61N1/08 ,  A61N1/39

CPC分类号： A61N1/37 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/37258 ,  A61N1/37288

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

公开(公告)号：US20100113954A1

公开(公告)日：2010-05-06

申请号：US12263383

申请日：2008-10-31

申请人： Xiaohong Zhou

发明人： Xiaohong Zhou

IPC分类号： A61B5/0402 ,  A61N1/362

CPC分类号： A61N1/3702 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/11 ,  A61B7/00 ,  A61N1/3925

摘要： A device and method of detecting the severity of myocardial ischemia and heart attack risk is provided. The method includes obtaining an electrogram signal, determining T-wave measurements based on the electrogram signal, and determining ST segment measurements based on the electrogram signal. The method also includes identifying T-wave alternans based on the T-wave measurements and identifying ST segment changes based on the ST segment measurements. The method further includes correlating the T-wave alternans with the ST segment changes in order to detect a severity of ischemia.

摘要翻译： 提供了一种检测心肌缺血严重程度和心脏病发作风险的方法。 该方法包括获得电描记图信号，基于电描记图信号确定T波测量，以及基于电描记图信号确定ST段测量。 该方法还包括基于T波测量识别T波交替，并基于ST段测量识别ST段变化。 该方法还包括将T波交替与ST段变化相关联，以便检测局部缺血的严重程度。

公开(公告)号：US07672733B2

公开(公告)日：2010-03-02

申请号：US11116970

申请日：2005-04-28

申请人： Xiaohong Zhou ,  Thomas J. Mullen ,  Michael R. S. Hill ,  Steve R. Laporte ,  Gary W. King

发明人： Xiaohong Zhou ,  Thomas J. Mullen ,  Michael R. S. Hill ,  Steve R. Laporte ,  Gary W. King

IPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/365

CPC分类号： A61N1/0551 ,  A61N1/36114 ,  A61N1/36135

摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.

摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。