公开(公告)号：US5270303A

公开(公告)日：1993-12-14

申请号：US924753

申请日：1992-08-04

申请人： Fujio Suzuki ,  Yuji Hiraki ,  Jun Kondo ,  Akihito Kamizono ,  Hideho Tanaka ,  Yutaka Teranishi

发明人： Fujio Suzuki ,  Yuji Hiraki ,  Jun Kondo ,  Akihito Kamizono ,  Hideho Tanaka ,  Yutaka Teranishi

IPC分类号： C07K14/51 ,  A61K37/02 ,  C07K7/04

CPC分类号： C07K14/51

摘要： A novel chondromodulin-II protein having a molecular weight of about 16,000 dalton on SDS-PAGE, capable of stimulating the growth of chondrocytes with or without fibroblast growth factor and promoting the differential potency of said cells, and a pharmaceutical composition containing said protein as an active ingredient.

公开(公告)号：US5228114A

公开(公告)日：1993-07-13

申请号：US760919

申请日：1991-09-17

申请人： Fujio Suzuki

发明人： Fujio Suzuki

IPC分类号： H01L21/00

CPC分类号： H01L21/67248 ,  H01L21/67115

摘要： A heat-treating apparatus which heat-treats a multiple of objects such as a plate or the like, with a batch scheme. A reaction chamber houses the multiple of the objects to be treated. An electrical heater is provided outside of the reaction chamber for heat-treating the multiple of objects to be treated at a predetermined temperature. A temperature detector detects a temperature within the reaction chamber and has main and reserve temperature detectors. A damage detector detects damage to the main and reserve temperature detectors. A controller controls the electrical heater normally in accordance with a detection output from the main temperature detector of the temperature detector. When the damage of the main temperature detector is detected by the damage detector, the controller controls the electrical heater in accordance with a detection output from the reserve temperature detector of the temperature detector.

摘要翻译： 一种热处理装置，其以批次方案热处理诸如板等的多个物体。 反应室容纳待处理物体的数量。 在反应室外部设置电加热器，用于在预定温度下对多个待处理物体进行热处理。 温度检测器检测反应室内的温度，并具有主和备用温度检测器。 损坏检测器检测到主和备用温度检测器的损坏。 控制器根据来自温度检测器的主温度检测器的检测输出正常地控制电加热器。 当损坏检测器检测到主温度检测器的损坏时，控制器根据温度检测器的储备温度检测器的检测输出控制电加热器。

公开(公告)号：US5137820A

公开(公告)日：1992-08-11

申请号：US199809

申请日：1988-05-27

申请人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

发明人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

IPC分类号： A61K38/44 ,  C12N9/02

CPC分类号： C12N9/0089 ,  A61K38/446 ,  Y10S530/815

摘要： The invention provides a superoxide dismutase derivative of the general formula[SOD][Z].sub.nwherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino group by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.

公开(公告)号：US4473581A

公开(公告)日：1984-09-25

申请号：US377151

申请日：1982-05-11

申请人： Nakao Ishida ,  Hiroshi Satoh ,  Fujio Suzuki ,  Kouhei Miyao

发明人： Nakao Ishida ,  Hiroshi Satoh ,  Fujio Suzuki ,  Kouhei Miyao

IPC分类号： A61K31/28 ,  A61P37/00 ,  A61P43/00 ,  C07F7/30 ,  C12N5/00

CPC分类号： C07F7/30 ,  A61K31/28 ,  Y10S435/811 ,  Y10S514/889

摘要： Therapeutic induction of interferon production in living animal cells is effected by subjecting such cells to the species-specific interferon inducing effect of an organogermanium compound having the formula:(GeCH.sub.2 CH.sub.2 COX).sub.2 O.sub.3wherein X is --OH,--NH.sub.2 or O--alkyl.

公开(公告)号：US07138607B2

公开(公告)日：2006-11-21

申请号：US10871277

申请日：2004-06-21

申请人： Wenling Wang ,  Koichi Sakamoto ,  Fujio Suzuki ,  Moyuru Yasuhara

发明人： Wenling Wang ,  Koichi Sakamoto ,  Fujio Suzuki ,  Moyuru Yasuhara

IPC分类号： F27B5/14

CPC分类号： H01L22/20 ,  H01L21/3185 ,  H01L21/324 ,  Y10S438/907 ,  Y10S438/909 ,  Y10S438/935

摘要： The invention is a method of determining a set temperature profile of a method of controlling respective substrate temperatures of plurality of groups in accordance with respective corresponding set temperature profiles. The invention includes a first heat processing step of controlling respective substrate temperatures of a plurality of groups in accordance with respective predetermined provisional set temperature profiles for first-batch substrates that are classified into the plurality of groups, and of introducing a process gas to conduct a heat process to form films on the substrates; a first film-thickness measuring step of measuring a thickness of the films formed on the substrates; and a first set-temperature-profile amending step of respectively amending the provisional set temperature profiles based on the measured thickness, in such a manner that a thickness of films formed during a heat process is substantially the same between the plurality of groups.

摘要翻译： 本发明是一种根据各自对应的设定温度曲线来确定控制多个组的各个衬底温度的方法的设定温度曲线的方法。 本发明包括第一热处理步骤，根据分类为多个组的第一批衬底的各自的预定临时设定温度曲线来控制多个组的各个衬底温度，以及引入工艺气体以进行 热处理以在基材上形成薄膜; 测量形成在基板上的膜的厚度的第一膜厚测量步骤; 以及第一设定温度曲线修正步骤，分别基于所测量的厚度修正临时设定温度曲线，使得在加热过程中形成的薄膜的厚度在多个组之间基本相同。

公开(公告)号：US07015202B2

公开(公告)日：2006-03-21

申请号：US10694616

申请日：2003-10-23

申请人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

发明人： Fujio Suzuki ,  Makiko Kobayashi ,  Tokuichiro Utsunomiya ,  Hiroatsu Matsumoto ,  Midori Takeda ,  Shigemi Iwata

IPC分类号： A61K31/70 ,  A61K31/56

CPC分类号： A61K31/473 ,  A61K31/57 ,  A61K31/704 ,  A61K31/7052

摘要： The object of the present invention is to provide the use of glycyrrhizin and its derivatives for inhibition of MCP-1 production. The present invention discloses an MCP-1 production inhibition method and pharmaceutical composition for the same comprising administration of glycyrrhizin and its derivatives in an amount effective for said inhibition to mammals in which migration of monocytes or T lymphocytes is increased, or production of IL-10 is increased, and inhibition of said increase is desired.

摘要翻译： 本发明的目的是提供甘草甜素及其衍生物用于抑制MCP-1产生的用途。 本发明公开了一种MCP-1产生抑制方法及其药物组合物，其含有对所述抑制单核细胞或T淋巴细胞迁移的哺乳动物有效量的甘草甜素及其衍生物的给药量，或产生IL-10 增加，并且希望抑制所述增加。

公开(公告)号：US06787377B2

公开(公告)日：2004-09-07

申请号：US10333585

申请日：2003-01-24

申请人： Wenling Wang ,  Koichi Sakamoto ,  Fujio Suzuki ,  Moyuru Yasuhara

发明人： Wenling Wang ,  Koichi Sakamoto ,  Fujio Suzuki ,  Moyuru Yasuhara

IPC分类号： G01R3126

CPC分类号： H01L22/20 ,  H01L21/3185 ,  H01L21/324 ,  Y10S438/907 ,  Y10S438/909 ,  Y10S438/935

摘要： The invention is a method of determining a set temperature profile for a method of controlling respective substrate temperatures of a plurality of groups in accordance with respective corresponding set temperature profiles, in a method of heat processing a plurality of substrates that are classified into the plurality of groups. The invention includes a first heat processing step of controlling respective substrate temperatures of a plurality of groups in accordance with respective predetermined provisional set temperature profiles for first-batch substrates that are classified into the plurality of groups, and of introducing a process gas to conduct a heat process to form films on the substrates; a first film-thickness measuring step of measuring a thickness of the films formed on the substrates; and a first set-temperature-profile amending step of respectively amending the provisional set temperature profiles based on the measured thickness, in such a manner that a thickness of films formed during a heat process is substantially the same between the plurality of groups. In the first heat processing step, the provisional set temperature profiles are profiles whose set temperatures change as time passes.

公开(公告)号：US06495805B2

公开(公告)日：2002-12-17

申请号：US09933671

申请日：2001-08-22

申请人： Koichi Sakamoto ,  Wenling Wang ,  Fujio Suzuki ,  Moyuru Yasuhara ,  Keisuke Suzuki

发明人： Koichi Sakamoto ,  Wenling Wang ,  Fujio Suzuki ,  Moyuru Yasuhara ,  Keisuke Suzuki

IPC分类号： H05B302

CPC分类号： H01L21/67757 ,  H01L21/67248 ,  H01L21/67781

摘要： This invention is a method of determining set temperature trajectories for a heat treatment system that conducts a first heat treatment process and a second heat treatment process to an object to be processed. The method comprises the steps of: conducting the first heat treatment process to a first test object to be processed, by using a temporary first set temperature trajectory; measuring a result of the first heat treatment process produced on the first test object to be processed; and determining a first set temperature trajectory for the first heat treatment process by correcting the temporary first set temperature trajectory on the basis of the measured result of the first heat treatment process. The method also comprises the steps of: conducting the second heat treatment process to a second test object to be processed to which the first heat treatment process has been conducted by using the determined first set temperature trajectory, by using a temporary second set temperature trajectory; measuring a result of the first heat treatment process and the second heat treatment process produced on the second test object to be processed; and determining a second set temperature trajectory for the second heat treatment process by correcting the temporary second set temperature trajectory on the basis of the measured result of the first heat treatment process and the second heat treatment process.

摘要翻译： 本发明是一种确定对待处理物体进行第一热处理和第二热处理的热处理系统的设定温度轨迹的方法。 该方法包括以下步骤：通过使用临时的第一设定温度轨迹对待处理的第一测试对象进行第一热处理过程; 测量在待处理的第一测试对象上产生的第一热处理过程的结果; 以及通过基于第一热处理过程的测量结果校正临时第一设定温度轨迹来确定用于第一热处理过程的第一设定温度轨迹。 该方法还包括以下步骤：通过使用临时第二设定温度轨迹，通过使用所确定的第一设定温度轨迹，将第二热处理过程执行到已经进行了第一热处理过程的待处理的第二测试对象; 测量在待处理的第二测试对象上产生的第一热处理过程和第二热处理过程的结果; 以及通过基于第一热处理过程和第二热处理过程的测量结果校正临时第二设定温度轨迹来确定第二热处理过程的第二设定温度轨迹。

公开(公告)号：US6030980A

公开(公告)日：2000-02-29

申请号：US135591

申请日：1998-08-18

申请人： Fujio Suzuki

发明人： Fujio Suzuki

IPC分类号： A61K31/12 ,  A61K31/439 ,  A01N43/42

CPC分类号： A61K31/12 ,  A61K31/439

摘要： The present invention relates an agent for the treatment of infections, which comprises as the active ingredient at least one member selected from the group consisting of aconite-alkaloids, aconite tuber and an extract thereof, gingerol and analogues thereof, and rhizomes of ginger and a substance therefrom. The agent of the present invention has significant infection-protective and recovery effects and is useful to treat and prevent a variety of infections such as virus infections, fungal infections, opportunistic infections, etc.

摘要翻译： 本发明涉及用于感染治疗的药剂，其包含作为活性成分的至少一种选自由附子 - 生物碱，乌头块茎及其提取物，姜油及其类似物，姜和根茎的根茎 物质。 本发明的药剂具有显着的感染保护和恢复作用，可用于治疗和预防各种感染，如病毒感染，真菌感染，机会性感染等。

公开(公告)号：US5444157A

公开(公告)日：1995-08-22

申请号：US47033

申请日：1993-04-13

申请人： Fujio Suzuki ,  Yuji Hiraki ,  Hideho Tanaka ,  Akihito Kamizono ,  Jun Kondo ,  Yutaka Teranishi

发明人： Fujio Suzuki ,  Yuji Hiraki ,  Hideho Tanaka ,  Akihito Kamizono ,  Jun Kondo ,  Yutaka Teranishi

IPC分类号： A61K38/00 ,  C07K14/51 ,  C07K14/00

CPC分类号： C07K14/51 ,  A61K38/00

摘要： A novel chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF and promoting the differential potency of said cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

摘要翻译： 一种在SDS-PAGE上具有约26,000道尔顿分子量的新型软骨调节素-I蛋白，能够刺激具有或不含FGF的软骨细胞的生长并促进所述细胞的差异效力，编码所述蛋白质的DNA，含有所述DNA的表达载体 ，能够产生重组软骨调节素-I蛋白的转化体，通过培养所述转化体生产软骨调节素-I蛋白的方法和含有软骨调节素-I蛋白作为活性成分的药物组合物。