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58 条记录 (耗时 0.024 秒)

    Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same
    1.
    发明授权
    Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same 失效
    超氧化物歧化酶衍生物，其制备方法及其药用用途

    公开(公告)号：US5180582A

    公开(公告)日：1993-01-19

    申请号：US836861

    申请日：1992-02-19

    申请人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

    发明人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

    IPC分类号： A61K38/44 ,  C12N9/02

    CPC分类号： C12N9/0089 ,  A61K38/446

    摘要： The invention provides a superoxide dismutase derivative of the general formula[SOD][Z]wherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino groups by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by a removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.

    摘要翻译： 本发明提供了一种通式[SOD] [Z]的超氧化物歧化酶衍生物，其中[SOD]代表通过除去一个氢原子代替氨基，每个衍生自氨基的具有1至22个或24个基团的超氧化物歧化酶; [Z]表示单价共聚物基团，其构成单元为式“IMAGE”的基团，其中R 1，R 2，R 3和R 4各自表示氢原子或通过从烷醇中除去羟基而得到的残基 1至8个碳原子的烷基部分，含有1至4个碳原子的烷基部分的乙二醇单烷基醚或含有1至4个碳原子的烷基部分的甘油二烷基醚，条件是R 1或R 2以及R 3或R 4各自表示 氢原子和衍生自上述式的基团的残基，通过从其COOR1，COOR2，COOR3和COOR4基团之一除去OR1，OR2，OR3或OR4基团（其中羰基的碳原子上的键 所述单价共聚物基团的平均分子量为500〜200,000; n表示通过除去所述[SOD]中的一个氢原子而衍生自氨基的所述基团的数目的1-22或24的整数或其药学上可接受的盐。 还提供了制备上述衍生物和盐的方法。 本发明进一步涉及药物用途和用于口服给药的药物组合物。

    Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same
    2.
    发明授权
    Superoxide dismutase derivatives, a method of producing the same and medicinal uses of the same 失效
    超氧化物歧化酶衍生物，其生产方法及其药物用途

    公开(公告)号：US5137820A

    公开(公告)日：1992-08-11

    申请号：US199809

    申请日：1988-05-27

    申请人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

    发明人： Hiroshi Maeda ,  Fujio Suzuki ,  Tatsuya Oda

    IPC分类号： A61K38/44 ,  C12N9/02

    CPC分类号： C12N9/0089 ,  A61K38/446 ,  Y10S530/815

    摘要： The invention provides a superoxide dismutase derivative of the general formula[SOD][Z].sub.nwherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino group by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.

    Neocarzinostatin derivative composition for oral administration
    4.
    发明授权
    Neocarzinostatin derivative composition for oral administration 失效
    用于口服给药的新辅佐星素衍生物组合物

    公开(公告)号：US5389366A

    公开(公告)日：1995-02-14

    申请号：US061338

    申请日：1993-05-17

    申请人： Hiroshi Maeda ,  Fujio Suzuki ,  Kiichiro Oka ,  Shohei Tanaka

    发明人： Hiroshi Maeda ,  Fujio Suzuki ,  Kiichiro Oka ,  Shohei Tanaka

    IPC分类号： A61K47/48 ,  A61K31/74

    CPC分类号： A61K47/48176

    摘要： A composition for oral administration to cancer patients includes a neocarzinostatin derivative and from 0.1 and 100 ml per mg of the neocarzinostatin derivative of at least one fatty acid glyceride which has from 6 to 20 carbon atoms and which is noniodized. The composition is effective in the treatment of cancer by oral administration, including a solid cancerous tumor.

    摘要翻译： 用于癌症患者的口服给药组合物包括新碳青霉调节素衍生物，和0.1至100ml每毫克含有6至20个碳原子并被非碘化的至少一种脂肪酸甘油酯的新碳青霉素抑制素衍生物。 该组合物通过口服给药治疗癌症是有效的，包括固体癌性肿瘤。

    Method of temperature-calibrating heat treating apparatus
    8.
    发明授权
    Method of temperature-calibrating heat treating apparatus 有权
    热处理装置的温度校准方法

    公开(公告)号：US06329643B1

    公开(公告)日：2001-12-11

    申请号：US09653460

    申请日：2000-08-31

    申请人： Fujio Suzuki ,  Koichi Sakamoto ,  Wenling Wang ,  Moyuru Yasuhara

    发明人： Fujio Suzuki ,  Koichi Sakamoto ,  Wenling Wang ,  Moyuru Yasuhara

    IPC分类号： H05B102

    CPC分类号： H01L21/67253 ,  C30B25/10 ,  C30B31/12 ,  F27D19/00 ,  H01L21/67248

    摘要： A second vertical heat treating apparatus is temperature-calibrated based on a heat treatment result obtained by a first vertical heat treating apparatus for reference. First, temperature measurement wafers is heated in the first apparatus to obtain set values of temperature controllers for a target value of temperature. Then, wafers are subjected to an oxidizing process in the first apparatus by using these set values to form an oxide film. The thickness of the oxide film is measured and recorded as a reference film thickness. Then, wafers are subjected to an oxidizing process in a second apparatus at temperatures near the target value to form an oxide film. The thickness of the oxide film is measured, and difference in thickness between the oxide film formed in the second apparatus and the reference film thickness is obtained. The oxidizing process in the second apparatus is repeated to obtain set values of temperature controllers for the second apparatus at the time when the difference in film thickness becomes zero. The second apparatus is temperature-calibrated on the basis of the set value thus obtained.

    摘要翻译： 基于由第一垂直热处理装置获得的热处理结果进行参考的第二垂直热处理装置进行温度校准。 首先，在第一装置中加热温度测量晶片，以获得目标温度值的温度控制器的设定值。 然后，通过使用这些设定值在第一装置中对晶片进行氧化处理，形成氧化膜。 氧化膜的厚度被测量并记录为参考膜厚度。 然后，在靠近目标值的温度下，在第二装置中对晶片进行氧化处理，以形成氧化膜。 测量氧化膜的厚度，并且获得在第二装置中形成的氧化膜之间的厚度差和参考膜厚度。 重复第二装置中的氧化处理，以获得当膜厚度差为零时第二装置的温度控制器的设定值。 基于由此获得的设定值对第二装置进行温度校准。

    Epoxy group-containing vinylidene fluoride copolymer and its application to secondary battery
    9.
    发明授权
    Epoxy group-containing vinylidene fluoride copolymer and its application to secondary battery 失效
    含环氧基的偏二氟乙烯共聚物及其在二次电池中的应用

    公开(公告)号：US5739234A

    公开(公告)日：1998-04-14

    申请号：US646492

    申请日：1996-05-08

    申请人： Hidetora Kashio ,  Katsuo Horie ,  Fujio Suzuki

    发明人： Hidetora Kashio ,  Katsuo Horie ,  Fujio Suzuki

    IPC分类号： C08F14/22 ,  C08F16/14 ,  C08F22/10 ,  C08F214/22 ,  C08F216/14 ,  C08F222/16 ,  C08L27/16 ,  H01M4/62 ,  H01M6/10

    CPC分类号： H01M4/623 ,  C08F214/227 ,  H01M4/621 ,  H01M2300/0025 ,  H01M4/525 ,  H01M4/625 ,  H01M6/10

    摘要： A vinylidene fluoride copolymer having a relatively high molecular weight is formed by copolymerizing (a) vinylidene fluoride as a principal component, (b) a small amount of epoxy group-containing monomer, and (c) an optional component, such as an unsaturated dibasic acid monoester functioning as a curing agent for the epoxy group. When cured with an optional epoxy curing agent, the vinylidene fluoride copolymer provides a cured product having an adhesion with a metal substrate, etc., and also showing excellent solvent resistance and chemical resistance. The vinylidene fluoride copolymer is particularly suitable for constituting a binder for producing an electrode for a non-aqueous solvent-type secondary battery.

    摘要翻译： 通过共聚（a）偏二氟乙烯作为主要成分，（b）少量含环氧基的单体，和（c）任选的组分，如不饱和二元碱，形成具有较高分子量的偏二氟乙烯共聚物 用作环氧基的固化剂的酸性单酯。 当使用任选的环氧固化剂固化时，偏二氟乙烯共聚物提供了与金属基材等具有粘合性的固化产物，并且还具有优异的耐溶剂性和耐化学性。 偏二氟乙烯共聚物特别适用于构成用于制造非水溶剂型二次电池用电极的粘合剂。