公开(公告)号：US11382790B2

公开(公告)日：2022-07-12

申请号：US15499534

申请日：2017-04-27

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  Joel N. Jimenez Lozano ,  Like Zeng ,  George Frangineas, Jr. ,  Linda Pham

IPC分类号： A61F7/00 ,  A61K9/06 ,  A61K9/00 ,  A61B90/00

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

公开(公告)号：US20210038278A1

公开(公告)日：2021-02-11

申请号：US17072020

申请日：2020-10-15

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  George Frangineas, JR. ,  Kristine Tatsutani ,  Linda Pham

IPC分类号： A61B18/02 ,  A61F7/00 ,  A61H1/00 ,  A61N7/00 ,  A61K31/045 ,  A61K31/047 ,  A61B90/00

摘要： Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

公开(公告)号：US10912599B2

公开(公告)日：2021-02-09

申请号：US15833329

申请日：2017-12-06

申请人： Zeltiq Aesthetics, Inc.

发明人： Michael P. O'Neil ,  Leonard C. DeBenedictis ,  George Frangineas, Jr.

IPC分类号： A61B18/02 ,  A61F7/00 ,  A61H1/00 ,  A61N7/00 ,  A61K31/045 ,  A61K31/047 ,  A61B90/00 ,  A61B18/00

摘要： Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

公开(公告)号：US10555831B2

公开(公告)日：2020-02-11

申请号：US15499349

申请日：2017-04-27

申请人： Zeltiq Aesthetics, Inc.

发明人： Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis

IPC分类号： A61F7/02 ,  A61F7/00

摘要： A method and system in accordance with particular embodiments includes applying a substance onto skin of a human subject. A method for treating a subject's skin includes applying a hydrogel to the skin which contains the substance. The hydrogel and the skin are cooled using a cooling applicator to treat tissue via the cooling treatment by either freezing or not freezing tissue.

公开(公告)号：US20190125424A1

公开(公告)日：2019-05-02

申请号：US16233951

申请日：2018-12-27

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  George Frangineas, JR. ,  Kristine Tatsutani ,  Linda Pham

IPC分类号： A61B18/02 ,  A61F7/00 ,  A61K31/045 ,  A61K31/047 ,  A61H1/00 ,  A61N7/00 ,  A61B90/00 ,  A61B18/00

摘要： Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

公开(公告)号：US20170326042A1

公开(公告)日：2017-11-16

申请号：US15498867

申请日：2017-04-27

申请人： Zeltiq Aesthetics, Inc.

发明人： Like Zeng ,  Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis

IPC分类号： A61K8/14 ,  A61Q19/06 ,  A61Q19/00 ,  A61Q9/00 ,  A61K41/00 ,  A61K9/127 ,  A61F7/00 ,  A61K8/34 ,  A61K8/46 ,  A61Q19/08

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. The applied substance can include a freezing point depressant and a liposome, an oil-in-water emulsion, a water-in-oil emulsion, or an oil-in-oil emulsion and can be configured to protect or target tissue. The substance and a surface of the skin can be cooled using the applicator to treat acne and other skin conditions.

公开(公告)号：US20160089550A1

公开(公告)日：2016-03-31

申请号：US14855017

申请日：2015-09-15

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  George Frangineas, JR.

IPC分类号： A61N7/02

CPC分类号： A61N7/02 ,  A61B18/14 ,  A61B18/20 ,  A61B2018/00023 ,  A61B2018/00452 ,  A61B2018/00797 ,  A61B2018/0262 ,  A61F7/00 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61N2007/0008 ,  A61N2007/0034

摘要： Systems and methods that enable tissue cooling and delivery of energy for altering tissue are described herein. Aspects of the disclosure are directed to, for example, heating tissue at treatment zones to ablate, denature, reorganize, coagulate, or otherwise alter the tissue to affect the cosmetic appearance of the patient. The method can include, for example, removing heat from the target region of the human subject before, during, and/or after energy delivery to cool tissue to a temperature below normal body temperature to inhibit pain.

摘要翻译： 这里描述了能够组织冷却和递送用于改变组织的能量的系统和方法。 本公开的方面涉及例如在治疗区域加热组织以消融，变性，重组，凝结或以其它方式改变组织以影响患者的美容外观。 该方法可以包括例如在能量递送之前，期间和/或之后从人类受试者的目标区域除去热量，以将组织冷却到低于正常体温的温度以抑制疼痛。

公开(公告)号：US20150216720A1

公开(公告)日：2015-08-06

申请号：US14611127

申请日：2015-01-30

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  George Frangineas, JR. ,  Kristine Tatsutani ,  Linda Pham

IPC分类号： A61F7/00 ,  A61H1/00

CPC分类号： A61B18/02 ,  A61B18/0206 ,  A61B90/04 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61B2090/065 ,  A61F7/00 ,  A61F7/007 ,  A61F2007/0003 ,  A61F2007/0004 ,  A61F2007/0019 ,  A61F2007/0036 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61H1/006 ,  A61H1/008 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00

摘要： Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.

摘要翻译： 描述了用于改善皮肤或其它目标区域的外观的治疗系统，方法和装置，以及用于提供其它治疗。 该技术的方面旨在通过收紧皮肤，改善皮肤色调或质地，消除或减少皱纹，增加皮肤光滑度或改善脂肪团的外观来改善皮肤的外观。 治疗可以包括冷却患者皮肤的表面并检测冷却的皮肤中的至少一个冻结事件。 在检测到冻结事件之后，治疗系统可以继续冷却患者的皮肤，以使组织的至少部分冻结状态持续一段时间。