公开(公告)号：US20210045912A1

公开(公告)日：2021-02-18

申请号：US16945789

申请日：2020-07-31

申请人： Zeltiq Aesthetics, Inc.

发明人： Austin Root ,  William Pennybacker ,  George Frangineas, JR. ,  Clive Heke ,  Leonard C. DeBenedictis

IPC分类号： A61F7/00

摘要： Systems for treating a subject's tissue can include a thermally conductive cup, a sealing member, and/or a liner assembly. The systems can include an applicator capable of being reconfigured for a particular treatment site. Components of the applicator can be replaced to achieve a desired configuration. The replaceable components can include contoured heads, liners, and/or sensors. The applicator can draw a vacuum to install various components and/or draw tissue into the applicator. The applicator can cool and/or heat the tissue to affect targeted tissue.

公开(公告)号：US20200323750A1

公开(公告)日：2020-10-15

申请号：US16861148

申请日：2020-04-28

申请人： Zeltiq Aesthetics, Inc.

发明人： Like Zeng ,  Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis

IPC分类号： A61K8/14 ,  A61K8/34 ,  A61Q19/06 ,  A61Q19/08 ,  A61Q19/00 ,  A61K9/127 ,  A61F7/00 ,  A61P17/10 ,  A61K9/00

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. The applied substance can include a freezing point depressant and a liposome, an oil-in-water emulsion, a water-in-oil emulsion, or an oil-in-oil emulsion and can be configured to protect or target tissue. The substance and a surface of the skin can be cooled using the applicator to treat acne and other skin conditions.

公开(公告)号：US10524956B2

公开(公告)日：2020-01-07

申请号：US15400885

申请日：2017-01-06

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  Like Zeng ,  George Frangineas, Jr. ,  Joel N. Jimenez Lozano

IPC分类号： A61F7/00 ,  A61F7/02

摘要： A method and apparatus in accordance with a particular embodiment of the present invention includes applying adhesive onto skin of a human subject. An applicator is then brought into contact with the adhesive such the adhesive is disposed between the applicator and the subject's skin. The applicator is activated to cool a tissue region via the subject's skin, via the heat-transfer surface of the applicator, and via the adhesive. While the tissue region cools, the adhesive also cools, thereby reversibly strengthening adhesion between the subject's skin and the heat-transfer surface and forming a strong bond therebetween. The strengthened adhesion inhibits any movement of the applicator relative to the skin. After cooling the tissue region, the adhesive is warmed, thereby weakening the adhesion which allows the heat-transfer surface of the applicator to be easily separated from the skin.

公开(公告)号：US20170326346A1

公开(公告)日：2017-11-16

申请号：US15498789

申请日：2017-04-27

申请人： Zeltiq Aesthetics, Inc.

发明人： Joel N. Jimenez Lozano ,  George Frangineas, JR. ,  Like Zeng ,  Leonard C. DeBenedictis

IPC分类号： A61M37/00 ,  A61F7/00

CPC分类号： A61F7/0085 ,  A61B2090/0463 ,  A61F7/007 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0076 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61F2007/0219 ,  A61M2037/0007

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. A subject's skin can be altered to facilitate absorption of applied substances. A substance can be applied to altered skin so that the substance is absorbed into the skin. The treatment site can be cooled to initiate a freeze event in the skin to freeze tissue. The substance can be a coupling media that promotes or inhibits freezing of tissue.

公开(公告)号：US20150216719A1

公开(公告)日：2015-08-06

申请号：US14611052

申请日：2015-01-30

申请人： Zeltiq Aesthetics, Inc

发明人： Leonard C. DeBenedictis ,  George Frangineas, JR. ,  Kristine Tatsutani ,  Linda Pham

IPC分类号： A61F7/00 ,  A61N7/00 ,  A61H1/00

CPC分类号： A61B18/02 ,  A61B18/0206 ,  A61B90/04 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61B2090/065 ,  A61F7/00 ,  A61F7/007 ,  A61F2007/0003 ,  A61F2007/0004 ,  A61F2007/0019 ,  A61F2007/0036 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61H1/006 ,  A61H1/008 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00

摘要： Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance sites with cellulite. Treatments can include cooling a surface of a patient's skin and detecting freezing in the cooled skin. The tissue can be cooled after the freeze event is detected so to maintain the frozen state of the tissue to improve the appearance of the treatment site.

摘要翻译： 描述了用于改善皮肤或其它目标区域的外观的治疗系统，方法和装置。 该技术的方面旨在通过收紧皮肤，改善皮肤色调或质地，消除或减少皱纹，增加皮肤光滑度或用脂肪团改善外观部位来改善皮肤的外观。 治疗可以包括冷却患者皮肤的表面并检测冷却的皮肤中的冷冻。 在检测到冻结事件之后，可以冷却组织，以便保持组织的冷冻状态，以改善治疗部位的外观。

公开(公告)号：US20240180604A1

公开(公告)日：2024-06-06

申请号：US18485282

申请日：2023-10-11

申请人： Zeltiq Aesthetics, Inc.

发明人： Michael P. O'Neil ,  Leonard C. DeBenedictis ,  George Frangineas, JR.

IPC分类号： A61B18/02 ,  A61B18/00 ,  A61B90/00 ,  A61F7/00 ,  A61H1/00 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00

CPC分类号： A61B18/02 ,  A61B18/0206 ,  A61B90/04 ,  A61F7/00 ,  A61F7/007 ,  A61H1/006 ,  A61H1/008 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61B2090/065 ,  A61F2007/0003 ,  A61F2007/0004 ,  A61F2007/0019 ,  A61F2007/0036 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096

摘要： Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

公开(公告)号：US20240164938A1

公开(公告)日：2024-05-23

申请号：US18239393

申请日：2023-08-29

申请人： Zeltiq Aesthetics, Inc.

发明人： Leonard C. DeBenedictis ,  Joel N. Jimenez Lozano ,  Like Zeng ,  George Frangineas, JR. ,  Linda Pham

IPC分类号： A61F7/00 ,  A61B90/00 ,  A61K9/00 ,  A61K9/06

CPC分类号： A61F7/0085 ,  A61K9/0014 ,  A61K9/06 ,  A61B2090/0463 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0076 ,  A61F2007/0086 ,  A61F2007/0093 ,  A61F2007/0095

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

公开(公告)号：US20240122822A1

公开(公告)日：2024-04-18

申请号：US18453217

申请日：2023-08-21

申请人： Zeltiq Aesthetics, Inc.

发明人： Like Zeng ,  Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis

IPC分类号： A61K8/14 ,  A61F7/00 ,  A61K8/34 ,  A61K9/00 ,  A61K9/127 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08

CPC分类号： A61K8/14 ,  A61F7/0085 ,  A61K8/345 ,  A61K9/0014 ,  A61K9/127 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61K9/107

摘要： A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. The applied substance can include a freezing point depressant and a liposome, an oil-in-water emulsion, a water-in-oil emulsion, or an oil-in-oil emulsion and can be configured to protect or target tissue. The substance and a surface of the skin can be cooled using the applicator to treat acne and other skin conditions.

公开(公告)号：US11819257B2

公开(公告)日：2023-11-21

申请号：US17143163

申请日：2021-01-07

申请人： Zeltiq Aesthetics, Inc.

发明人： Michael P. O'Neil ,  Leonard C. DeBenedictis ,  George Frangineas, Jr.

IPC分类号： A61B18/02 ,  A61F7/00 ,  A61H1/00 ,  A61N7/00 ,  A61K31/045 ,  A61K31/047 ,  A61B90/00 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B18/0206 ,  A61B90/04 ,  A61F7/00 ,  A61F7/007 ,  A61H1/006 ,  A61H1/008 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61B2090/065 ,  A61F2007/0003 ,  A61F2007/0004 ,  A61F2007/0019 ,  A61F2007/0036 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096

摘要： Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

公开(公告)号：US20180271767A1

公开(公告)日：2018-09-27

申请号：US15914840

申请日：2018-03-07

申请人： Zeltiq Aesthetics, Inc.

发明人： Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis ,  Like Zeng ,  George Frangineas, JR.

IPC分类号： A61K8/60 ,  A61K8/86 ,  A61K8/36 ,  A61K8/42 ,  C07H3/04 ,  A61N1/32 ,  A61N1/30

CPC分类号： A61K8/602 ,  A61B18/0206 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61F7/007 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0094 ,  A61K8/361 ,  A61K8/42 ,  A61K8/86 ,  A61K2800/244 ,  A61N1/30 ,  A61N1/327 ,  A61N2007/0034 ,  C07H3/04

摘要： A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.