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106 条记录 (耗时 0.036 秒)

    Sulfamoyl benzamide derivatives and methods of their use
    33.
    发明申请
    Sulfamoyl benzamide derivatives and methods of their use 失效
    氨磺酰苯甲酰胺衍生物及其使用方法

    公开(公告)号：US20060079557A1

    公开(公告)日：2006-04-13

    申请号：US11251160

    申请日：2005-10-13

    申请人： Roland Dolle ,  Karin Worm ,  Q. Zhou

    发明人： Roland Dolle ,  Karin Worm ,  Q. Zhou

    IPC分类号： C07D211/06 ,  A61K31/445

    CPC分类号： C07D205/04 ,  C07C311/16 ,  C07C311/21 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/48 ,  C07D209/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/96 ,  C07D213/40 ,  C07D215/58 ,  C07D295/26

    摘要： Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and/or modulating ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.

    摘要翻译： 公开了新型氨磺酰苯甲酰胺化合物，含有氨磺酰苯甲酰胺化合物的药物组合物及其药物用途的方法。 在某些实施方案中，氨磺酰苯甲酰胺化合物是大麻素受体的激动剂和/或调节配体，并且尤其可用于治疗和/或预防疼痛，胃肠道疾病，炎症，自身免疫疾病，缺血性病症，免疫相关 疾病，高血压，神经系统疾病和神经变性疾病，用于提供针对缺血和再灌注作用的心脏保护，用于诱导恶性细胞凋亡，用于抑制与神经损伤相关的机械痛觉过敏以及作为食欲刺激剂。

    Sulfonylamino phenylacetamide derivatives and methods of their use
    34.
    发明授权
    Sulfonylamino phenylacetamide derivatives and methods of their use 失效
    磺酰基氨基苯乙酰胺衍生物及其使用方法

    公开(公告)号：US06992193B2

    公开(公告)日：2006-01-31

    申请号：US10458135

    申请日：2003-06-10

    申请人： Bertrand Le Bourdonnec ,  Christopher William Ajello ,  Roland E. Dolle

    发明人： Bertrand Le Bourdonnec ,  Christopher William Ajello ,  Roland E. Dolle

    IPC分类号： C07D275/04

    CPC分类号： C07D295/125 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/55 ,  C07D207/12 ,  A61K2300/00

    摘要： Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably: (1) bind with high affinity to κ opioid receptors; (2) display good opioid receptor selectivity of κ versus μ and κ versus δ; and (3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.

    摘要翻译： 公开了通式的磺酰基氨基苯乙酰胺衍生物。 还公开了含有这些化合物的药物组合物及其使用方法。 在某些实施方案中，本发明的化合物优选：（1）以高亲和力结合κ阿片受体; （2）显示良好的阿片受体选择性κ与mu和κ与delta的关系; 和（3）基本上不抑制细胞色素P450酶活性，特别是CYP2D6，CYP2C9和CYP3A4。

    Compositions containing opioid antagonist
    35.
    发明申请
    Compositions containing opioid antagonist 有权
    含有阿片拮抗剂的组合物

    公开(公告)号：US20050272776A1

    公开(公告)日：2005-12-08

    申请号：US11143535

    申请日：2005-06-02

    申请人： John Buehler

    发明人： John Buehler

    IPC分类号： A61K31/454

    CPC分类号： A61K47/10 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/451 ,  A61K31/454 ,  A61K47/02 ,  A61K47/26

    摘要： Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.

    摘要翻译： 公开了含有阿片样物质拮抗剂，特别是阿维莫潘及其活性代谢物的组合物，具有口服或肠胃外给药的改善的溶解度和生物利用度，可注射剂型，试剂盒及其制备和使用方法。 在优选的实施方案中，本发明提供了含有阿片样物质拮抗剂，特别是阿维莫潘及其活性代谢物的可注射制剂，其具有低易溶解性，易于制备，在储存期间是稳定的，并且当肠胃外特别是通过注射时提供最大量的阿片样物质拮抗剂。 结果通过处理技术和部件选择的组合来实现。

    COMPOSITIONS CONTAINING OPIOID ANTAGONISTS
    38.
    发明申请
    COMPOSITIONS CONTAINING OPIOID ANTAGONISTS 审中-公开
    含有阿片样物质拮抗剂的组合物

    公开(公告)号：US20140057947A1

    公开(公告)日：2014-02-27

    申请号：US14070287

    申请日：2013-11-01

    申请人： Adolor Corporation

    发明人： John D. BUEHLER

    IPC分类号： A61K31/451

    CPC分类号： A61K47/10 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/451 ,  A61K31/454 ,  A61K47/02 ,  A61K47/26

    摘要： Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.

    摘要翻译： 公开了含有阿片样物质拮抗剂，特别是阿维莫潘及其活性代谢物的组合物，具有口服或肠胃外给药的改善的溶解度和生物利用度，可注射剂型，试剂盒及其制备和使用方法。 在优选的实施方案中，本发明提供了含有阿片样物质拮抗剂，特别是阿维莫潘及其活性代谢物的可注射制剂，其具有低易溶解性，易于制备，在储存期间是稳定的，并且当肠胃外特别是通过注射时提供最大量的阿片样物质拮抗剂。 结果通过处理技术和部件选择的组合来实现。

    Methods for delivering a drug to a hospital patient for short-term use while minimizing long-term use of the drug
    39.
    发明授权
    Methods for delivering a drug to a hospital patient for short-term use while minimizing long-term use of the drug 有权
    将药物递送到医院病人短期使用，同时尽量减少长期使用药物的方法

    公开(公告)号：US08645160B2

    公开(公告)日：2014-02-04

    申请号：US13541628

    申请日：2012-07-03

    申请人： George Raymond Maurer ,  Robert Barnett Jones

    发明人： George Raymond Maurer ,  Robert Barnett Jones

    IPC分类号： G06Q50/00

    CPC分类号： A61K31/451 ,  G06F19/00 ,  G06F19/3456 ,  G06Q50/22

    摘要： Novel methods for delivering a drug to hospital patients for short-term in-hospital use while minimizing long-term use of the drug. Embodiments are provided in which hospitals are identified which may be eligible to treat patients, for example, perform certain types of surgery, and which have measures in place to limit use of the drug to short-term use. The identified hospitals are preferably registered in a storage medium, including computer readable storage media, and may be authorized to receive the shipments of the drug. The received drug may then be dispensed to the patient.

    摘要翻译： 将药物递送给医院病人进行短期住院使用的最新方法，同时尽量减少长期使用药物。 提供的实施例是哪些医院被识别为可能有资格治疗患者，例如执行某些类型的手术，并且哪些医疗措施已经将药物的使用限制为短期使用。 所识别的医院优选地登记在包括计算机可读存储介质的存储介质中，并且可以被授权接收药物的运输。 然后将所接收的药物分配给患者。