公开(公告)号：US07766875B2

公开(公告)日：2010-08-03

申请号：US11904724

申请日：2007-09-28

申请人： Terri Kapur ,  Daniel Keeley ,  Greg Schorn

发明人： Terri Kapur ,  Daniel Keeley ,  Greg Schorn

IPC分类号： A61M5/178

CPC分类号： A61M25/0054 ,  A61M25/007 ,  A61M2025/0063

摘要： A catheter for delivery of a therapeutic agent directly into a targeted tissue that reduces or substantially prevents reflux and back flow by providing rigidity and strength via a stylet thereby eliminating the need for a guide or delivery sheath during positioning. The catheter has a flexible proximal section and a substantially rigid distal section formed from a plurality of distal subsections. The proximal and distal sections having decreasing outer diameters starting from the proximal end and advancing towards the distal end. The distal subsection closest to the distal end providing an adjustable flow rate via multiple output ports defined radially therein while the distal end itself is closed off.

摘要翻译： 用于将治疗剂直接递送到目标组织中的导管，其通过通过探针提供刚性和强度来减少或基本上防止回流和回流，由此在定位期间不需要引导或输送护套。 导管具有柔性近端部分和由多个远端部分形成的基本刚性的远端部分。 近端部分和远端部分具有从近端开始并朝向远端前进的外径减小的部分。 最靠近远端的远端部分通过径向定位的多个输出端口提供可调节的流速，同时远端本身被封闭。

公开(公告)号：US07745670B2

公开(公告)日：2010-06-29

申请号：US12343750

申请日：2008-12-24

申请人： Thomas M. DiMauro

发明人： Thomas M. DiMauro

IPC分类号： C07C39/12 ,  C07C39/16

CPC分类号： C07C39/21 ,  C07C229/12 ,  C07C229/34 ,  C07C229/36 ,  C07C271/54

摘要： Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's Disease.

摘要翻译： 基于姜黄素和羟基茋的杂交的新型分子，如白藜芦醇。 相信这些新型分子在治疗阿尔茨海默病方面将具有特殊的应用。

公开(公告)号：US07691124B2

公开(公告)日：2010-04-06

申请号：US11344989

申请日：2006-01-31

申请人： Keith Balgobin

发明人： Keith Balgobin

IPC分类号： A61M29/00 ,  A61F2/06

CPC分类号： A61B17/12022 ,  A61B17/0057 ,  A61B17/1214 ,  A61B2017/00477 ,  A61B2017/00575 ,  A61B2017/12054

摘要： Therapeutic devices, especially vaso-occlusive devices or embolic coils, are delivered by an apparatus that includes a pullwire having a tine or tines that have an offset orientation that engages a therapeutic device. The pullwire passes through an opening of a headpiece. When the pullwire moves in a relative proximal direction, the tine moves toward a straight-line orientation, and the therapeutic device is liberated from the tine and from the pullwire. At this state, the therapeutic device is ready for deployment at a desired intraluminal location.

摘要翻译： 治疗装置，特别是血管闭塞装置或栓塞线圈，由包括具有与治疗装置接合的偏移取向的齿或尖齿的拉丝的装置递送。 拉丝穿过头盔的开口。 当拉线在相对的近端方向上移动时，齿朝向直线方向移动，并且治疗装置从叉齿和拉线释放。 在这种状态下，治疗装置准备在期望的腔室内部署。

公开(公告)号：US20100010415A1

公开(公告)日：2010-01-14

申请号：US12500192

申请日：2009-07-09

申请人： Daniel J. McCusker ,  Alan J. Dextradeur

发明人： Daniel J. McCusker ,  Alan J. Dextradeur

IPC分类号： A61M27/00

CPC分类号： A61M27/006 ,  Y10T137/0508

摘要： A valve for use in a shunt system to drain fluid from one part of a patient's body to another is provided. In an exemplary embodiment, the valve is operable at a threshold pressure that is selectively adjustable up to at least about 400 mm H2O at increments in the range of about 10 mm H2O to 40 mm H2O. The ability of the valve to operate at a high threshold pressure and to be adjusted at relatively small increments renders the valve particularly advantageous for use in younger hydrocephalus patients. In particular, the operating pressure of the valve can be gradually limited in small increments over a period of time to slowly force the patient's own resorption system to circulate cerebrospinal fluid. At high operating pressures of at least about 400 mm H2O shunt independence can be achieved thereby allowing the shunt to be successfully removed.

摘要翻译： 提供了用于分流系统以将流体从患者身体的一部分排出到另一部分的阀。 在一个示例性实施例中，该阀可在阈值压力下操作，该阈值压力可选择性地调节至多约400mm H 2 O，其范围为约10毫米H 2 O至40毫米H 2 O。 阀在高阈值压力下操作并以相对小的增量进行调节的能力使得瓣膜特别有利于在年轻脑积水患者中使用。 特别地，可以在一段时间内以小增量逐渐限制阀的操作压力，以缓慢地迫使患者自己的吸收系统循环脑脊液。 在至少约400mm的高操作压力下，可以实现H 2 O分流器独立性，从而允许分流器被成功地移除。

公开(公告)号：US07604658B2

公开(公告)日：2009-10-20

申请号：US10839952

申请日：2004-05-04

申请人： Stephen Ferrer Wilson ,  Michael C. Gorhan

发明人： Stephen Ferrer Wilson ,  Michael C. Gorhan

IPC分类号： A61B17/84

CPC分类号： A61M39/0247 ,  A61B5/031 ,  A61B17/3403 ,  A61B17/3423 ,  A61B90/11 ,  A61B2017/3411 ,  A61B2017/3419 ,  A61B2017/3445 ,  A61B2017/3449 ,  A61B2017/3466 ,  A61B2017/349 ,  A61B2090/103 ,  A61M27/006 ,  A61M2039/025 ,  A61M2039/0264 ,  A61M2039/0267 ,  A61M2210/0693

摘要： A cranial bolt secured to a skull of a patient includes a threaded portion and a lumen portion. Threaded portion has an inner surface forming a central passageway which extends throughout the threaded portion. The inner surface includes a connector mating with the lumen portion. The threaded portion has an outer surface having a plurality of threads for engaging a hole formed in the patient's skull. The lumen portion includes a stem portion that enters the central passageway and engages the mating connector. A fluid tight seal is formed between the inner surface of the threaded portion and the stem portion. At least two lumens are disposed through the stem portion and the base portion. The lumens have a proximal end opening outside the skull and a distal end opening inside the skull. One embodiment includes sensor lumens diverging from the centerline and another allows lumen portion to rotate independent of threaded portion.

摘要翻译： 固定在患者颅骨上的颅骨螺栓包括螺纹部分和内腔部分。 螺纹部分具有形成贯穿螺纹部分延伸的中心通道的内表面。 内表面包括与内腔部分配合的连接器。 螺纹部分具有外表面，该外表面具有用于接合形成在患者头骨中的孔的多个螺纹。 管腔部分包括进入中心通道并接合配合连接器的杆部分。 在螺纹部分的内表面和杆部分之间形成流体密封。 通过杆部和基部设置至少两个流明。 腔内具有在头骨外部的近端开口和头骨内部的远端开口。 一个实施例包括从中心线发散的传感器腔，另一个实施例允许管腔部分独立于螺纹部分旋转。

公开(公告)号：US20090156960A1

公开(公告)日：2009-06-18

申请号：US12372313

申请日：2009-02-17

申请人： Christophe Mauge ,  Alan J. Dextradeur ,  Daniel J. McCusker ,  Stefan Meyer ,  Volker Boedecker ,  Robert G. Kraus ,  Max G. Ostermeier

发明人： Christophe Mauge ,  Alan J. Dextradeur ,  Daniel J. McCusker ,  Stefan Meyer ,  Volker Boedecker ,  Robert G. Kraus ,  Max G. Ostermeier

IPC分类号： A61B5/03

CPC分类号： A61B5/031 ,  A61F2/24 ,  A61M27/006

摘要： A pressure sensing catheter having a pressure sensor and an antenna that is coupled to the pressure sensor, e.g., by a connector, are provided. The pressure sensor can be adapted to measure a pressure surrounding the catheter, and the antenna can be adapted to telemetrically communicate the measured pressure to an external device. In an exemplary embodiment, the antenna, pressure sensor, and/or connector are hermetically sealed, e.g., by the catheter and/or a coating, to prevent the antenna, pressure sensor, and connector from coming into contact with fluid, thereby allowing the catheter to be permanently implanted or otherwise used for long term use. Exemplary methods for manufacturing and using pressure sensing catheters are also provided.

摘要翻译： 具有压力传感器的压力传感导管，其具有例如通过连接器耦合到压力传感器的压力传感器和天线。 压力传感器可以适于测量导管周围的压力，并且天线可以适于将测量的压力遥测地传递到外部设备。 在示例性实施例中，天线，压力传感器和/或连接器例如通过导管和/或涂层被密封，以防止天线，压力传感器和连接器与流体接触，从而允许 导管永久植入或以其他方式长期使用。 还提供了用于制造和使用压力传感导管的示例性方法。

公开(公告)号：US20090005720A1

公开(公告)日：2009-01-01

申请号：US11771015

申请日：2007-06-29

申请人： Lev Ludin ,  Christopher Mauge

发明人： Lev Ludin ,  Christopher Mauge

IPC分类号： A61M5/00

CPC分类号： A61M27/006 ,  A61M27/008 ,  A61M2205/3337

摘要： Devices and methods for regulating and directing bodily fluids from one region of a patient to another region are disclosed. In general, an apparatus is provided that can include an implantable shunt system and a system controller. The implantable shunt system can have an adjustable valve for regulating the flow of fluid, a sensor element for measuring a physiological characteristic of a patient, and an electromechanical valve actuator that can be adapted to adjust a resistance of the valve. The implantable shunt system can be in electrical communication with the system controller. The system controller can generally be adapted to receive a physiological characteristic of the patient and operate the electromechanical valve actuator to adjust a resistance of the valve. The apparatus can also include an external programming device that is in communication with the system controller.

摘要翻译： 公开了用于将体液从患者的一个区域调节和引导到另一个区域的装置和方法。 通常，提供了一种可以包括可植入分流系统和系统控制器的装置。 可植入分流系统可以具有用于调节流体流量的可调节阀，用于测量患者的生理特征的传感器元件以及可适于调节阀的阻力的机电阀致动器。 可植入分流系统可与系统控制器电连通。 系统控制器通常可适于接收患者的生理特征并操作机电阀致动器以调节阀的阻力。 该装置还可以包括与系统控制器通信的外部编程装置。

公开(公告)号：US20080208359A1

公开(公告)日：2008-08-28

申请号：US12113520

申请日：2008-05-01

申请人： Robert E. Sommerich

发明人： Robert E. Sommerich

IPC分类号： A61F2/02

CPC分类号： A61L27/24 ,  A61L27/50 ,  A61L2430/32

摘要： A dural graft is provided having improved stiffness characteristics relative to conventional dural substitutes. The dural graft can be formed from a collagen material having a stiffness between about 0.1 pounds per inch (lb./in.) and 0.25 lb./in. Relative to the collagen material forming conventional dural graft substitutes, the decreased stiffness of the collagen material of the present dural graft can provide the graft with a relatively improved or increased pliability. As a result of the increased pliability, the dural graft can sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The reduced stiffness of the collagen material can also provide for a relatively improved or increased flexibility or elasticity of the dural graft. The increased flexibility of the dural graft minimizes tearing of the graft when handled or manipulated during an implantation procedure.

摘要翻译： 提供了相对于常规硬脑膜替代物具有改善的硬度特性的硬脑膜移植物。 硬脑膜移植物可以由具有约0.1磅/英寸（lb./in。）和0.25磅/英寸之间的刚度的胶原材料形成。 相对于形成常规硬脑膜移植物替代物的胶原材料，本发明硬膜移植物的胶原材料的刚度降低可为移植物提供相对改善或增加的柔韧性。 由于增加的柔韧性，硬膜移植物可以充分地符合其所施加的组织表面的曲率，例如脑膜的弯曲表面。 胶原材料的刚度降低还可以提供硬脑膜移植物的相对改善或增加的柔韧性或弹性。 硬脑膜移植物的增加的灵活性使得在植入手术过程中处理或操纵时移植物的撕裂最小化。

公开(公告)号：US07334594B2

公开(公告)日：2008-02-26

申请号：US11170795

申请日：2005-06-29

申请人： Lev Ludin

发明人： Lev Ludin

IPC分类号： F16K35/16 ,  A61M27/00

CPC分类号： A61M27/006 ,  A61M2205/3507 ,  A61M2205/3515 ,  A61M2205/3523 ,  F16K35/16 ,  Y10S128/903 ,  Y10T137/0318 ,  Y10T137/7069 ,  Y10T137/7256 ,  Y10T137/7878 ,  Y10T137/7922 ,  Y10T137/7927

摘要： A shunt valve assembly includes an electromechanical brake mechanism that locks a position of a pressure setting mechanism within a shunt valve assembly. The electromechanical brake can maintain the position of the pressure setting mechanism in the presence of a relatively strong magnetic field to maintain a set pressure differential within the shunt valve assembly. In certain cases, the shunt valve requires repositioning of the pressure setting mechanism within the shunt valve assembly to adjust a fluid flow rate through the shunt valve assembly. A clinician can activate an external controller to transmit a signal to the shunt valve assembly through magnetically coupled antennas between the controller and the shunt valve. The shunt valve assembly utilizes the signal to activate the braking mechanism and unlock the pressure setting mechanism. The clinician then operates the controller to non-invasively reposition the pressure setting mechanism and adjust the pressure at which the shunt valve opens.

摘要翻译： 分流阀组件包括机电制动机构，其将分压阀组件内的压力设定机构的位置锁定。 机电制动器可以在存在相对较强的磁场的情况下保持压力设定机构的位置，以保持分流阀组件内的设定压力差。 在某些情况下，分流阀需要在分流阀组件内重新定位压力设定机构，以调节通过分流阀组件的流体流速。 临床医生可以激活外部控制器以通过控制器和分流阀之间的磁耦合天线将信号传输到分流阀组件。 分流阀组件利用该信号激活制动机构并解锁压力设定机构。 临床医生然后操作控制器以非侵入性地重新定位压力设定机构并调节分流阀打开的压力。

公开(公告)号：US20070005000A1

公开(公告)日：2007-01-04

申请号：US11170795

申请日：2005-06-29

申请人： Lev Ludin

发明人： Lev Ludin

IPC分类号： A61M5/00

CPC分类号： A61M27/006 ,  A61M2205/3507 ,  A61M2205/3515 ,  A61M2205/3523 ,  F16K35/16 ,  Y10S128/903 ,  Y10T137/0318 ,  Y10T137/7069 ,  Y10T137/7256 ,  Y10T137/7878 ,  Y10T137/7922 ,  Y10T137/7927

摘要： A shunt valve assembly includes an electromechanical brake mechanism that locks a position of a pressure setting mechanism within a shunt valve assembly. The electromechanical brake can maintain the position of the pressure setting mechanism in the presence of a relatively strong magnetic field to maintain a set pressure differential within the shunt valve assembly. In certain cases, the shunt valve requires repositioning of the pressure setting mechanism within the shunt valve assembly to adjust a fluid flow rate through the shunt valve assembly. A clinician can activate an external controller to transmit a signal to the shunt valve assembly through magnetically coupled antennas between the controller and the shunt valve. The shunt valve assembly utilizes the signal to activate the braking mechanism and unlock the pressure setting mechanism. The clinician then operates the controller to non-invasively reposition the pressure setting mechanism and adjust the pressure at which the shunt valve opens.

摘要翻译： 分流阀组件包括机电制动机构，其将分压阀组件内的压力设定机构的位置锁定。 机电制动器可以在存在相对较强的磁场的情况下保持压力设定机构的位置，以保持分流阀组件内的设定压力差。 在某些情况下，分流阀需要在分流阀组件内重新定位压力设定机构，以调节通过分流阀组件的流体流速。 临床医生可以激活外部控制器以通过控制器和分流阀之间的磁耦合天线将信号传输到分流阀组件。 分流阀组件利用该信号激活制动机构并解锁压力设定机构。 临床医生然后操作控制器以非侵入性地重新定位压力设定机构并调节分流阀打开的压力。