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197 条记录 (耗时 0.023 秒)

    Contrast agents
    32.
    发明授权
    Contrast agents 失效
    对比剂

    公开(公告)号：US07662859B2

    公开(公告)日：2010-02-16

    申请号：US12031070

    申请日：2008-02-14

    申请人： Hanno Priebe

    发明人： Hanno Priebe

    IPC分类号： C07C275/30 ,  A61K31/175

    CPC分类号： C07C275/62 ,  A61K49/0433

    摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto.The invention also relates to methods of diagnosis and imaging employing such diagnostic compositions as contrast agents in particular in X-ray imaging, and to contrast media containing such compounds.

    摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及使用这种诊断组合物作为造影剂，特别是X射线成像的诊断和成像方法以及含有这些化合物的造影剂。

    Purification of Iodixanol
    33.
    发明申请
    Purification of Iodixanol 有权
    碘代醇的纯化

    公开(公告)号：US20080287711A1

    公开(公告)日：2008-11-20

    申请号：US12094500

    申请日：2006-11-29

    申请人： Bjorg Helga Mellesdal Strandmyr

    发明人： Bjorg Helga Mellesdal Strandmyr

    IPC分类号： C07C237/28

    CPC分类号： C07C231/24 ,  C07C237/46

    摘要： A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising ethanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”).

    摘要翻译： 通过在包含乙醇的溶剂中进行粗产物的纯化处理来制备碘克沙醇的方法。 粗产物可以从5-乙酰氨基-N，N'-双（2,3-二羟丙基）-2,4,6-三碘 - 间苯二甲酰胺（“化合物A”）的二聚化的水溶液中获得。

    IMAGING AGENTS
    34.
    发明申请
    IMAGING AGENTS 失效
    成像代理

    公开(公告)号：US20080267881A1

    公开(公告)日：2008-10-30

    申请号：US12141123

    申请日：2008-06-18

    申请人： Alan Cuthbertson ,  Magne Solbakken

    发明人： Alan Cuthbertson ,  Magne Solbakken

    IPC分类号： A61K49/04

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/60 ,  A61K47/6425

    摘要： The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma.

    摘要翻译： 本发明涉及式（I）化合物及其作为靶向载体的用途，所述靶向载体与血管发生相关的受体结合。 因此，这样的化合物可用于诊断或治疗例如恶性疾病，心脏病，子宫内膜异位，炎症相关疾病，类风湿性关节炎和卡波西肉瘤。

    MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent
    37.
    发明授权
    MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent 有权
    用于通过超极化造影剂体内测量温度或pH值的MR方法

    公开(公告)号：US07251519B2

    公开(公告)日：2007-07-31

    申请号：US10240754

    申请日：2001-04-12

    申请人： Oskar Axelsson ,  Jan Henrik Ardenkjaer-Larsen ,  Sven Månsson ,  Stefan Petersson ,  Ib Leunbach

    发明人： Oskar Axelsson ,  Jan Henrik Ardenkjaer-Larsen ,  Sven Månsson ,  Stefan Petersson ,  Ib Leunbach

    IPC分类号： A61B5/05

    CPC分类号： G01R33/5601 ,  G01R33/4804 ,  Y10T436/24

    摘要： The present invention provides a method of MR investigation of a sample, said method comprising: (i) nuclear spin polarizing a high T1 MR imaging agent which contains in its molecular structure at least two hyperpolarisable nuclei within the same molecule, the frequency difference between the two resonance lines from said nuclei, δυ, being dependent upon either the temperature or the pH of said sample; (ii) administering the nuclear spin polarized MR imaging agent to said sample; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in said MR imaging agent; and (iv) detecting and manipulating magnetic resonance signals from said sample using a single-shot RARE acquisition sequence with shifted data acquisition.

    摘要翻译： 本发明提供了一种样品的MR研究方法，所述方法包括：（i）使自旋极化的高T1MR成像剂，其在其分子结构中包含在相同分子内的至少两个超极化核， 来自所述核的两条共振线，δupsilon，取决于所述样品的温度或pH值; （ii）向所述样品施用核自旋极化MR成像剂; （iii）将所述样品暴露于以选定的频率激发所述MR成像剂中的核自旋跃迁的辐射; 和（iv）使用具有移位数据采集的单次RARE获取序列检测和操纵来自所述样本的磁共振信号。

    Metal complex compounds
    38.
    发明授权
    Metal complex compounds 失效
    金属络合物

    公开(公告)号：US07198776B2

    公开(公告)日：2007-04-03

    申请号：US10496852

    申请日：2002-11-28

    申请人： Jo Klaveness ,  Pal Rongved

    发明人： Jo Klaveness ,  Pal Rongved

    IPC分类号： A61B5/055 ,  C07F5/00

    CPC分类号： A61K49/06

    摘要： The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said metal complex compounds.

    摘要翻译： 本发明涉及金属络合物化合物，用于MRI的造影剂和用于NMR光谱的体内NMR标记，其包括所述金属络合物和用于体内测定生理参数的方法。 酶活性或pH值使用所述金属络合物。

    MOLECULAR PROBE FOR NUCLEIC ACID DETECTION, PREPARATION AND USE THEREOF
    39.
    发明公开
    MOLECULAR PROBE FOR NUCLEIC ACID DETECTION, PREPARATION AND USE THEREOF 审中-公开

    公开(公告)号：US20240167091A1

    公开(公告)日：2024-05-23

    申请号：US18016444

    申请日：2021-07-16

    申请人： GE Healthcare AS

    发明人： Zhoushe ZHAO ,  Hongli LI ,  Yanmei WANG

    IPC分类号： C12Q1/6883 ,  C12Q1/6816

    CPC分类号： C12Q1/6883 ,  C12Q1/6816 ,  C12Q2600/158

    摘要： The present disclosure relates to molecular probes for nucleic acid detection, and preparation and uses thereof. In particular, described herein is a molecular probe for detection of a nucleic acid, comprising, (1) a molecular probe carrier which comprises a cell penetrating peptide and a detectable label coupled to the cell penetrating peptide, and (2) a targeting oligonucleotide, wherein the targeting oligonucleotide is attached to the molecular probe carrier. Also described herein are a method for preparing the molecular probe, a method for detection of a nucleic acid, and a kit for detection of a nucleic acid.