公开(公告)号：US08092854B2

公开(公告)日：2012-01-10

申请号：US12875741

申请日：2010-09-03

Applicant: William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Susan Leander ,  Christopher Batich

Inventor： William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Susan Leander ,  Christopher Batich

IPC: B05D3/02

CPC classification number: A01N33/12 ,  A01N37/12 ,  A61L2/18 ,  A61L2/232 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/80 ,  A01N25/10 ,  A01N25/24 ,  A01N25/34 ,  A01N2300/00

Abstract: A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.

Abstract translation: 描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出 使用和存储。 描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

公开(公告)号：US20100311865A1

公开(公告)日：2010-12-09

申请号：US12845979

申请日：2010-07-29

Applicant: William Toreki ,  Gerald Olderman ,  Gregory Staab

Inventor： William Toreki ,  Gerald Olderman ,  Gregory Staab

IPC: C09D5/00

CPC classification number: A01N25/34 ,  A01N33/12 ,  B32B13/08 ,  E04C2/043 ,  Y10T428/31986 ,  Y10T428/31993 ,  Y10T428/31996 ,  A01N43/40 ,  A01N37/12 ,  A01N55/02 ,  A01N2300/00

Abstract: A novel gypsum board having improved antimicrobial and antibacterial properties is disclosed. The board comprises a gypsum core, front and back paper facings, and a polymeric antimicrobial or antibacterial compound effective at inhibiting fungal growth. Preferred polymeric antimicrobial and antibacterial compounds include polyDADMAC, polyTMMC, and quaternized polyvinyl pyridine derivatives. The novel gypsum board further comprises a non-polymeric antimicrobial or antibacterial compound. Preferred non-polymeric antimicrobial or antibacteral compounds include cetyl pyridinium chloride and sodium pyrithione. The polymeric antimicrobial or antibacterial compound can be present in the gypsum core and/or on one or both of the paper facings. The non-polymeric antimicrobial or antibacterial compound may be encapsulated in a material or ionically associated with the polymeric antimicrobial or antibacterial compound to allow releases of the non-polymeric antimicrobial or antibacterial compound over time and/or upon exposure to moisture. Methods for preparing the aforementioned novel gypsum board are also disclosed.

Abstract translation: 公开了具有改进的抗菌和抗菌性能的新型石膏板。 该板包括石膏芯，正面和背面纸面，以及有效抑制真菌生长的聚合抗微生物或抗菌化合物。 优选的聚合抗微生物和抗菌化合物包括polyDADMAC，polyTMMC和季铵化的聚乙烯吡啶衍生物。 新型石膏板还包含非聚合抗微生物或抗菌化合物。 优选的非聚合抗微生物或抗菌化合物包括氯化十六烷基吡啶鎓和吡啶硫酮钠。 聚合物抗微生物或抗菌化合物可以存在于石膏芯中和/或在一个或两个纸面上。 非聚合物抗微生物剂或抗菌化合物可以被包封在与聚合物抗微生物或抗菌化合物的离子缔合物质中，以允许随着时间和/或暴露于水分而释放非聚合物抗微生物剂或抗菌化合物。 还公开了制备上述新型石膏板的方法。

公开(公告)号：US20100247615A1

公开(公告)日：2010-09-30

申请号：US12796708

申请日：2010-06-09

Applicant: William Toreki ,  Susan Leander ,  Gerald M. Olderman

Inventor： William Toreki ,  Susan Leander ,  Gerald M. Olderman

IPC: A61K33/40 ,  A61F13/15 ,  A61F13/00 ,  B32B1/02 ,  A61L15/16

CPC classification number: C08F8/00 ,  A01N37/02 ,  A01N59/00 ,  A61K33/40 ,  A61K47/58 ,  A61K2800/56 ,  A61L15/24 ,  A61L15/44 ,  A61L15/46 ,  A61L15/60 ,  A61L2300/11 ,  A61L2300/404 ,  A61L2300/802 ,  C08L33/08 ,  C08L33/10 ,  Y10T428/1324

Abstract: This invention pertains to a polymeric composition and an antimicrobial composition, each comprising a superabsorbent polymer (SAP), such as used in diapers and sanitary napkins, and peroxide. The superabsorbent material can be made by the process of treating a preformed SAP, such as a crosslinked polyacrylate salt, with a treatment solution comprising hydrogen peroxide dissolved in water, followed by drying. The resulting superabsorbent material has strong antimicrobial activity. Optionally, the treatment solution may also contain a metal salt, including those of zinc, zirconium, and magnesium.

Abstract translation: 本发明涉及聚合物组合物和抗微生物组合物，其各自包含超吸收聚合物（SAP），例如用于尿布和卫生巾中的过氧化物。 超吸收材料可以通过用预先形成的SAP（例如交联聚丙烯酸盐）处理，其中包括溶解在水中的过氧化氢的处理溶液，然后干燥来制备。 所得超吸收材料具有很强的抗菌活性。 任选地，处理溶液还可以含有金属盐，包括锌，锆和镁的金属盐。

公开(公告)号：US20100211035A1

公开(公告)日：2010-08-19

申请号：US12772686

申请日：2010-05-03

Applicant: William Toreki ,  Gerald Olderman

Inventor： William Toreki ,  Gerald Olderman

IPC: A61L15/46

CPC classification number: A01N25/34 ,  A61F13/8405 ,  A61L15/46 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/606 ,  A01N25/10 ,  A01N33/12 ,  A01N47/44

Abstract: This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.

Abstract translation: 本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。 将涂层施加到诸如纱布式伤口敷料的基底上。 在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。 在多长度聚合物链上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效果的吸收剂或超吸收剂表面。

公开(公告)号：US20080206293A1

公开(公告)日：2008-08-28

申请号：US12036107

申请日：2008-02-22

Applicant: William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Gregory Schultz ,  Gerald Olderman ,  Gregory Staab

Inventor： William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Gregory Schultz ,  Gerald Olderman ,  Gregory Staab

IPC: A61K9/00 ,  A61F13/00 ,  A61K31/65 ,  A61K38/18 ,  A01N25/08 ,  A01P1/00 ,  A61P31/04 ,  A61K38/02 ,  A01N25/00 ,  A61K31/165 ,  A61K31/14

CPC classification number: A61L15/44 ,  A61L15/46

Abstract: This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such as doxycycline. The Wound dressing material is absorbent and acts as a substrate for antimicrobial and antiprotease agents as well as bioactive agents. More generally, this invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymeric molecules and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy. Utilization of non-leaching coatings having a plurality of anionic or cationic sites is used according to this invention to bind a plurality of oppositely charged biologically or chemically active compounds, and to release the bound oppositely charged biologically or chemically active compounds from said substrate over a period of time to achieve desired objectives as diverse as improved wound healing to reduction in body odor.

Abstract translation: 本发明涉及具有非浸出抗微生物活性的抗微生物伤口敷料，可释放的抗微生物剂和抗蛋白酶试剂，以及控释释放生物活性剂如多西环素。 伤口敷料材料是吸收剂并用作抗微生物剂和抗蛋白酶剂以及生物活性剂的底物。 更一般来说，本发明涉及具有抗菌性能的非浸出涂层的材料的方法和组合物。 将涂层施加到诸如纱布式伤口敷料，粉末和其它底物的基底上。 在底物和形成涂层的聚合物分子之间形成共价，非浸出，不可水解的键。 在多长度聚合物分子上具有高浓度的抗微生物群和相当长的平均链长，有助于具有高水平抗微生物效能的吸收剂或超吸收剂表面。 根据本发明使用具有多个阴离子或阳离子位点的非浸出涂层的使用以结合多个带相反电荷的生物或化学活性化合物，并通过一个或多个阴离子或化学活性化合物从所述底物上释放结合的带相反电荷的生物或化学活性化合物 一段时间以达到预期的目标，如改善伤口愈合以减少体臭。

公开(公告)号：US20060165617A1

公开(公告)日：2006-07-27

申请号：US11278461

申请日：2006-04-03

Applicant: David Lerner ,  Gregory Schultz

Inventor： David Lerner ,  Gregory Schultz

IPC: A61K8/97 ,  A61K31/56 ,  A61K31/704

CPC classification number: A61K8/42 ,  A61K8/492 ,  A61K8/4986 ,  A61K8/602 ,  A61K8/63 ,  A61K8/97 ,  A61K31/56 ,  A61K31/567 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/08

Abstract: A cosmetic topical formulation and method are directed toward diminishing skin wrinkling and fine lines and improving skin tone. It contains a matrix metalloproteinase inhibitor, MMPI, e.g. batimastat or marimastat, and a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid (such as various phytoestrogens found in herbal preparations). Exemplary phytoestrogens include triterpenoid glycosides. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, a composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking. The method of the invention involves administering the components such as in a dermal preparation.

Abstract translation: 化妆品局部制剂和方法旨在减少皮肤皱纹和细纹并改善肤色。 它含有基质金属蛋白酶抑制剂，MMPI， 巴马司他或马拉马斯特，以及天然雌激素，例如真正的雌激素化合物，如17-β雌二醇，或雌激素样类固醇（如草药制剂中发现的各种植物雌激素）。 示例性植物雌激素包括三萜糖苷。 本发明的某些组合物可用于最小化对皮肤的光损伤，而在其它实施方案中，根据本发明的组合物可用于防止或最小化由吸烟引起的对皮肤的不利影响。 本发明的方法涉及给予诸如皮肤制剂中的组分。

公开(公告)号：US08926999B2

公开(公告)日：2015-01-06

申请号：US13616209

申请日：2012-09-14

Applicant: William Toreki ,  Albina Mikhaylova ,  Susan Leander ,  Bernd Liesenfeld ,  Gerald M. Olderman

Inventor： William Toreki ,  Albina Mikhaylova ,  Susan Leander ,  Bernd Liesenfeld ,  Gerald M. Olderman

IPC: A01N59/00 ,  B05D3/00 ,  A01P1/00 ,  D06M11/50 ,  C09K3/00 ,  D06M11/155 ,  D06M11/65 ,  D06M16/00

CPC classification number: D06M11/50 ,  A61L15/46 ,  A61L2300/11 ,  A61L2300/404 ,  C09D5/14 ,  C11D3/046 ,  C11D3/3947 ,  C11D17/048 ,  D06M11/155 ,  D06M11/57 ,  D06M11/65 ,  D06M16/00

Abstract: This invention pertains to method for imparting a durable antimicrobial activity to substrates, particularly textiles. An acetate-free metal and peroxide antimicrobial treatment formulation is prepared from a metal derivative, hydrogen peroxide and a source of hydroxide ion. The substrate is treated with the composition and dried to afford the treated substrate with antimicrobial activity. Zinc salts, ions, or complexes are preferred.

Abstract translation: 本发明涉及赋予基材，特别是纺织品持久的抗微生物活性的方法。 从金属衍生物，过氧化氢和氢氧根离子源制备无乙酸盐的金属和过氧化物抗微生物处理制剂。 用组合物处理底物并干燥以提供具有抗微生物活性的经处理的底物。 锌盐，离子或络合物是优选的。

公开(公告)号：US08343523B2

公开(公告)日：2013-01-01

申请号：US12350784

申请日：2009-01-08

Applicant: William Toreki ,  Gerald Olderman ,  Rustom S. Kanga

Inventor： William Toreki ,  Gerald Olderman ,  Rustom S. Kanga

IPC: A01N33/02 ,  A01N25/00 ,  A01P1/00

CPC classification number: A01N47/44 ,  A01N33/12 ,  A01N31/02 ,  A01N31/16 ,  A01N2300/00

Abstract: An alcohol- or glycol-soluble, water-insoluble, disinfectant composition and a method of using the same for disinfecting and for providing a prolonged antimicrobial property to a variety of surfaces, including skin. The composition comprises at least one alcohol or glycol and an antimicrobial polymer that is capable of imparting an antimicrobial property to a surface without the use of a metal or a metal-containing compound. The composition is applied to a surface and allowed to evaporate leaving a coating of antimicrobial polymer. Alternatively, the composition is incorporated into or within the substrate.

Abstract translation: 醇或二醇可溶的水不溶性消毒剂组合物及其使用方法，用于消毒，并为多种表面（包括皮肤）提供延长的抗微生物性能。 组合物包含至少一种醇或二醇和能够赋予表面抗微生物性能而不使用金属或含金属的化合物的抗微生物聚合物。 将组合物施加到表面并允许蒸发，留下抗微生物聚合物的涂层。 或者，将组合物掺入或在基底内。

公开(公告)号：US20100330261A1

公开(公告)日：2010-12-30

申请号：US12875741

申请日：2010-09-03

Applicant: William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Susan Leander ,  Christopher Batich

Inventor： William Toreki ,  Bernd Liesenfeld ,  David Moore ,  Susan Leander ,  Christopher Batich

IPC: B05D7/00 ,  B05D3/02 ,  B05D3/06

CPC classification number: A01N33/12 ,  A01N37/12 ,  A61L2/18 ,  A61L2/232 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/80 ,  A01N25/10 ,  A01N25/24 ,  A01N25/34 ,  A01N2300/00

Abstract: A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.

Abstract translation: 描述了将抗微生物阳离子聚电解质结合到基底表面的方法，其中由此附着到基底上的抗微生物赋予底物抗微生物性质，并且至少一部分结合的抗微生物剂在正常条件下基本上不可浸出 使用和存储。 描述了制造抗微生物材料的方法，其包括将基底暴露于抗微生物阳离子聚电解质溶液，然后彻底干燥曝光的底物，以赋予至少一部分抗微生物阳离子聚电解质非浸出性。

公开(公告)号：US20100291169A1

公开(公告)日：2010-11-18

申请号：US12830062

申请日：2010-07-02

Applicant: William Toreki ,  David N. Moore ,  Bernd Liesenfeld ,  Albina Mikhaylova ,  Gerald M. Olderman

Inventor： William Toreki ,  David N. Moore ,  Bernd Liesenfeld ,  Albina Mikhaylova ,  Gerald M. Olderman

IPC: A01N25/34 ,  A61K9/70 ,  A61K31/785 ,  A01N33/12 ,  A01P1/00 ,  A61P31/04 ,  B05D3/10 ,  C23C16/52 ,  B32B27/10 ,  B32B27/08 ,  B01J39/20

CPC classification number: A61F13/00995 ,  A61F13/00063 ,  A61F2013/0091 ,  A61F2013/00931 ,  A61L2/18 ,  A61L2/232 ,  A61L15/44 ,  A61L15/46 ,  A61L2202/24 ,  A61L2202/26 ,  Y10T428/3154 ,  Y10T428/31565 ,  Y10T428/31663 ,  Y10T428/31736 ,  Y10T428/3179 ,  Y10T428/31797

Abstract: Anionic polyelectrolytes are used as binding agents to reduce the solubility of cationic antimicrobial polyelectrolytes. Ionic attraction between the anionic stabilizing polyelectrolytes and the antimicrobial cationic polyelectrolytes results in formation of a polyelectrolyte complex (PEC). A treatment liquid comprising a stable colloid, suspension, dispersion, solution, coacervate, or emulsion of the PEC in an aqueous carrier is used to treat an article, thus coating, infiltrating, or infusing the PEC onto or into the article. Subsequent drying results in an antimicrobial article wherein the PEC is bound to the article and is significantly less prone, relative to either of the component polyelectrolytes, to being washed, leached, leaked, extracted, or migrated from the antimicrobial article during use, or when exposed to aqueous fluids or solvents. The antimicrobial article can be further treated with ethylene oxide which enhances its antimicrobial efficacy, its biocompatibility, and its utility in wound dressings, medical devices, clothing, etc.

Abstract translation: 阴离子聚电解质用作粘合剂以降低阳离子抗菌聚电解质的溶解度。 阴离子稳定聚电解质与抗微生物阳离子聚电解质之间的离子吸引导致聚电解质络合物（PEC）的形成。 使用包含PEC在水性载体中的稳定的胶体，悬浮液，分散体，溶液，凝聚层或乳液的处理液来处理制品，从而将PEC涂覆，渗透或注入到物品上或进入该物品。 随后的干燥导致抗微生物制品，其中PEC与制品结合，并且相对于组分聚电解质中的任何一种，在使用期间被洗涤，浸出，泄漏，提取或从抗微生物制品迁移，或者当 暴露于含水流体或溶剂。 抗菌制品可以进一步用环氧乙烷处理，提高其抗菌效能，其生物相容性及其在伤口敷料，医疗器械，衣服等中的应用。