公开(公告)号：US4889744B1

公开(公告)日：1993-03-09

申请号：US18919588

申请日：1988-05-02

IPC: A61F2/00 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  C08J9/26

CPC classification number: C08J9/26 ,  A61F2/0077 ,  A61F2/12 ,  A61L27/18 ,  A61L27/56 ,  B29C37/0053 ,  B29C41/14 ,  C08J2201/0446 ,  C08J2383/04 ,  Y10S128/21 ,  Y10S623/901 ,  C08L83/04

公开(公告)号：US11958036B1

公开(公告)日：2024-04-16

申请号：US18241387

申请日：2023-09-01

Applicant: King Faisal University

Inventor： Junaid Saleem ,  Safdar Hossain Sk ,  Zubair Khalid Baig Moghal ,  Gordon McKay

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C02F1/28 ,  C02F1/40 ,  C08J5/18 ,  C08J9/26 ,  C02F101/32 ,  C02F103/00

CPC classification number: B01J20/261 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/3007 ,  B01J20/3064 ,  B01J20/3071 ,  C02F1/285 ,  C02F1/40 ,  C08J5/18 ,  C08J9/26 ,  C02F2101/32 ,  C02F2103/007 ,  C02F2303/16 ,  C08J2201/0446 ,  C08J2205/044 ,  C08J2323/06

Abstract: Freestanding porous polyethylene thin film, and a method for preparing a freestanding porous polyethylene thin film. The method includes dissolving polyethylene in an organic solvent to form a solution under reflux conditions; adding a swellable pocket forming agent to the solution and mixing the solution until the swellable pocket forming agent is well-dispersed therein; applying the well-dispersed solution onto a solid substrate through spin coating to form a thin film on the solid substrate; peeling the thin film off the solid substrate; and extracting the swellable pocket forming agent from the peeled thin film by washing the peeled thin film in water, thereby obtaining a freestanding porous polyethylene thin film with swellable pockets, macro-voids, and micropores. The freestanding porous polyethylene thin film can be used as an oil sorbent. The freestanding porous polyethylene thin film has about 500 to about 800 swellable cavities per cm2.

公开(公告)号：US11883792B1

公开(公告)日：2024-01-30

申请号：US18241612

申请日：2023-09-01

Applicant: KING FAISAL UNIVERSITY

Inventor： Junaid Saleem ,  Safdar Hossain S K ,  Zubair Khalid Baig Moghal ,  Gordan McKay

IPC: B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C02F1/28 ,  C08J5/18 ,  C08J9/26 ,  C09K103/00 ,  C09K3/32 ,  C02F103/00 ,  C02F101/32

CPC classification number: B01J20/261 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/3007 ,  B01J20/3064 ,  B01J20/3071 ,  C02F1/285 ,  C08J5/18 ,  C08J9/26 ,  C02F2101/32 ,  C02F2103/007 ,  C02F2303/16 ,  C08J2201/0446 ,  C08J2323/12 ,  C09K3/32

Abstract: Sponge-like porous polypropylene thin film, and a method for preparing a sponge-like porous polypropylene thin film. The method includes dissolving polypropylene in an organic solvent to form a solution under reflux condition; adding a cavity forming agent to the solution and mixing the solution until the cavity forming agent is well-dispersed therein; applying the well-dispersed solution onto the solid substrate through spin coating to form a thin film on the solid substrate; peeling the thin film off the solid substrate; extracting the cavity forming agent from the peeled thin film by washing the peeled thin film in an aqueous or nonaqueous solvent, thereby obtaining a sponge-like porous polypropylene thin film with cavities, macro-voids, and micropores. The sponge-like porous polypropylene thin film is used as an oil sorbent. The sponge-like porous polypropylene thin film has about 400 to about 700 swellable cavities per cm2.

公开(公告)号：US11772306B2

公开(公告)日：2023-10-03

申请号：US17374521

申请日：2021-07-13

Applicant: NuVasive, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee

IPC: B29C43/04 ,  B29C67/20 ,  B29C44/58 ,  C08J9/26 ,  B29C33/00 ,  B29K71/00 ,  B29L31/00

CPC classification number: B29C43/04 ,  B29C33/00 ,  B29C44/58 ,  B29C67/202 ,  C08J9/26 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7532 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2300/22 ,  C08J2371/00

Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.

公开(公告)号：US20180193126A1

公开(公告)日：2018-07-12

申请号：US15854748

申请日：2017-12-26

Applicant: Vertera Inc.

Inventor： Wei-Hsang CHANG ,  Stephen Lee LAFFOON ,  Christopher S.D. LEE ,  David Lee SAFRANSKI

IPC: A61F2/00 ,  B29C44/34 ,  A61B6/12 ,  A61B6/00 ,  A61F2/44 ,  B29C67/20 ,  C08J9/26 ,  A61L27/56 ,  A61B90/00 ,  A61L27/18 ,  A61L27/50 ,  B29C44/04 ,  C08J9/00 ,  A61L31/06 ,  C08L71/00 ,  B29K71/00 ,  B29L31/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

公开(公告)号：US09889225B2

公开(公告)日：2018-02-13

申请号：US14614718

申请日：2015-02-05

Applicant: KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Mei-Ling Ho ,  Je-Ken Chang ,  Rajalakshmanan Eswaramoorthy ,  Shun-Cheng Wu ,  Yao-Hsien Wang

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  C08J9/26 ,  C08G63/91 ,  C12N5/0775

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08G63/912 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2207/10 ,  C08J2367/04 ,  C12N5/0667 ,  C12N2500/42 ,  C12N2501/999 ,  C12N2533/40 ,  C12N2537/10 ,  Y10T428/2982

Abstract: A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.

公开(公告)号：US09848973B2

公开(公告)日：2017-12-26

申请号：US15362223

申请日：2016-11-28

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: A61F2/00 ,  A61F2/44 ,  A61F2/28 ,  A61L31/06 ,  B29C67/20 ,  C08J9/00 ,  C08J9/26 ,  A61L27/18 ,  A61B90/00 ,  A61B6/00 ,  A61L27/50 ,  A61L27/56 ,  B29C44/04 ,  B29C44/34 ,  A61B6/12 ,  B29K71/00 ,  B29L31/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

公开(公告)号：US20170312949A1

公开(公告)日：2017-11-02

申请号：US15653047

申请日：2017-07-18

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S.D. Lee

IPC: B29C43/04 ,  B29C67/20 ,  C08J9/26 ,  B29C44/58 ,  B29C33/00 ,  B29L31/00 ,  B29K71/00

CPC classification number: B29C43/04 ,  B29C33/00 ,  B29C44/58 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7532 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2300/22 ,  C08J2371/00

Abstract: In general, in various embodiments, the present disclosure is directed systems and methods for producing a porous surface from a solid piece of polymer. In particular, the present disclosure is directed to systems that include a track assembly, mold assembly, press assembly, and methods for using the same for producing a porous surface from a solid piece of polymer. In some embodiments, the present systems and methods are directed to processing a polymer at a temperature below a melting point of the polymer to produce a solid piece of polymer with an integrated a porous surface.

公开(公告)号：US09504550B2

公开(公告)日：2016-11-29

申请号：US14752762

申请日：2015-06-26

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: A61F2/30 ,  A61F2/28 ,  A61F2/00 ,  A61L31/06 ,  B29C67/20 ,  C08J9/00 ,  C08J9/26 ,  B29K71/00

CPC classification number: A61F2/0077 ,  A61B6/12 ,  A61B6/50 ,  A61B90/39 ,  A61B2090/3966 ,  A61F2/44 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61F2210/0071 ,  A61F2250/0098 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L31/06 ,  A61L2430/38 ,  B29C44/0461 ,  B29C44/3415 ,  B29C67/202 ,  B29K2071/00 ,  B29L2031/753 ,  B29L2031/7546 ,  C08J9/0085 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2371/00 ,  C08L71/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将固体聚合物片的表面加热至加工温度并保持加工温度，同时使致孔剂层通过聚合物的表面移动，以形成包含聚合物的固体聚合物主体的基质层，以及 致孔剂层。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。

公开(公告)号：US09353235B1

公开(公告)日：2016-05-31

申请号：US14747660

申请日：2015-06-23

Applicant: Vertera, Inc.

Inventor： Wei-Hsiang Chang ,  Stephen Lee Laffoon ,  Christopher S. D. Lee ,  David Lee Safranski

IPC: B29C67/20 ,  C08J9/26 ,  A61F2/02

CPC classification number: B29C67/202 ,  A61F2/02 ,  A61F2/32 ,  A61F2/38 ,  A61F2002/30065 ,  A61F2002/30316 ,  A61F2210/0076 ,  A61F2240/001 ,  B29K2071/00 ,  B29K2105/04 ,  C08J9/0085 ,  C08J9/26 ,  C08J9/32 ,  C08J2201/0446 ,  C08J2361/16 ,  C08J2371/00

Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature below a melting point of the polymer and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract translation: 公开了一种由固体聚合物制备具有多孔层的聚合物的方法。 在各种实施方案中，该方法包括将聚合物固体片的表面加热至低于聚合物熔点的加工温度，并保持加工温度，同时使致孔剂层通过聚合物表面移动以形成基体层 包含聚合物和致孔剂层的固体聚合物体。 在至少一个实施方案中，该方法还包括从基质层去除致孔剂层的至少一部分以产生固体聚合物片的多孔层。