公开(公告)号：US20230233470A1

公开(公告)日：2023-07-27

申请号：US18001634

申请日：2021-06-23

Applicant: ViiV Healthcare Company

Inventor： Ian Paul CONN ,  Mark Robert DAVIES ,  Jose Maria FUEYO ,  Joanne HEAFIELD ,  Trevor Martin SHREEVES

IPC: A61K9/24 ,  A61K9/20 ,  A61K31/513 ,  A61K31/52

CPC classification number: A61K9/209 ,  A61K9/2018 ,  A61K9/2095 ,  A61K31/513 ,  A61K31/52

Abstract: The present invention relates to formulations comprising dolutegravir or a pharmaceutically acceptable salt thereof, abacavir or a pharmaceutically acceptable salt thereof and lamivudine, processes for making such formulations, and the use of such formulations in the treatment of HIV infection, in particular in the treatment of HIV infection in pediatric patients.

公开(公告)号：US11707508B2

公开(公告)日：2023-07-25

申请号：US16679425

申请日：2019-11-11

Applicant: ARES TRADING S.A. ,  Nicolas Chomont ,  Jean-Pierre Routy

Inventor： Alena Zalutskaya ,  John Gourley ,  Nicolas Chomont ,  Jean-Pierre Routy ,  Steven Deeks

IPC: A61K38/27 ,  A61P31/18 ,  A61K31/52 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/341 ,  A61K31/675 ,  A61K31/496 ,  A61K31/536 ,  A61K31/505 ,  A61K31/551 ,  A61K31/7072

CPC classification number: A61K38/27 ,  A61K31/341 ,  A61K31/496 ,  A61K31/505 ,  A61K31/52 ,  A61K31/536 ,  A61K31/551 ,  A61K31/675 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/7072 ,  A61P31/18

Abstract: The subject invention pertains to methods of treating HIV-1 infected subject comprising the administration of growth hormone to a subject infected by HIV-1. The subject may be undergoing co-administration of anti-retroviral therapies (ARTs), may be untreated with anti-retroviral drugs (ARDs) or may be in a period of time where no ART is being administered. Growth hormone may be administered at a fixed dosage for a set period of time or may be administered at a first dosage for a first period of time that may then be increased or decreased to a second dosage for a second period of time.

公开(公告)号：US20230226017A1

公开(公告)日：2023-07-20

申请号：US18007822

申请日：2021-06-04

Applicant: The General Hospital Corporation

Inventor： David R. Elmaleh

IPC: A61K31/353 ,  A61K31/664 ,  A61K31/52 ,  A61K31/506 ,  A61K9/00 ,  A61P31/14

CPC classification number: A61K31/353 ,  A61K31/664 ,  A61K31/52 ,  A61K31/506 ,  A61K9/0019 ,  A61K9/0075 ,  A61P31/14

Abstract: The present disclosure relates to a pharmaceutical composition, such as a dry powder inhalation formulation or an injectable formulation, comprising a mixture of an antiviral agent and a mast cell stabilizer. The present disclosure relates to a codrug comprising a residue of an antiviral agent covalently bonded via a labile bond to a residue of a compound of Formula (I) or Formula (II). The present disclosure further relates to a method of administering an antiviral agent and a Formula I/II compound, a pharmaceutical composition, or a codrug to treat coronavirus infection and/or associated inflammation.

公开(公告)号：US11701361B2

公开(公告)日：2023-07-18

申请号：US16959960

申请日：2019-01-07

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO

Inventor： John Cambier ,  Elizabeth Franks

IPC: A61K31/52 ,  A61P37/02 ,  A61P3/10

CPC classification number: A61K31/52 ,  A61P3/10 ,  A61P37/02

Abstract: Methods of using a phosphoinositide 3-kinase p110-delta inhibitor to treat, delay the onset, or slow the progression of an autoimmune disease or disorder in a subject, without suppressing the subject's B cell responses to exogenous antigens or rendering the subject immunocompromised, as well as pharmaceutical compositions containing phosphoinositide 3-kinase p110-delta inhibitors in amounts suitable for convenient and accurate administration within these therapeutic methods.

公开(公告)号：US20230218719A1

公开(公告)日：2023-07-13

申请号：US18154380

申请日：2023-01-13

Applicant: ALX Oncology Inc.

Inventor： Hong WAN ,  Bang Janet SIM ,  Sophia RANDOLPH ,  Jaume PONS ,  Tracy Chia-Chien KUO

IPC: A61K38/17 ,  A61K33/243 ,  A61K31/7072 ,  A61K31/337 ,  A61K31/517 ,  A61K31/282 ,  A61K31/513 ,  A61K31/7076 ,  A61K31/52 ,  A61K31/519 ,  A61P35/00 ,  A61K31/17 ,  A61K39/395 ,  A61K31/7068

CPC classification number: A61K38/1774 ,  A61K33/243 ,  A61K31/7072 ,  A61K31/337 ,  A61K31/517 ,  A61K31/282 ,  A61K31/513 ,  A61K31/7076 ,  A61K31/52 ,  A61K31/519 ,  A61P35/00 ,  A61K31/17 ,  A61K39/3955 ,  A61K31/7068

Abstract: Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRPα D1 domain variant and an Fc domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kits.

公开(公告)号：US11696918B2

公开(公告)日：2023-07-11

申请号：US16800813

申请日：2020-02-25

Applicant: ELIAN LLC

Inventor： Emidio A. Checcone ,  Christina Ramirez

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/22 ,  A61K9/00 ,  A61K9/70 ,  A61K45/06

CPC classification number: A61K31/522 ,  A61K9/0036 ,  A61K9/7023 ,  A61K31/52 ,  A61K45/06 ,  A61P31/22

Abstract: The present disclosure provides compositions and methods for the prevention of HSV infection in an HSV seronegative individual and for the treatment and prevention of recurrence in an HSV seropositive individual.

公开(公告)号：US20230165887A1

公开(公告)日：2023-06-01

申请号：US17934169

申请日：2022-09-21

Applicant: Astrocyte Pharmaceuticals, Inc. ,  The Board of Regents of the University of Texas System

Inventor： William S. KORINEK ,  James D. LECHLEITER ,  Theodore E. LISTON

IPC: A61K31/7076 ,  A61K31/52 ,  A61P25/00

CPC classification number: A61K31/7076 ,  A61K31/52 ,  A61P25/00

Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.

公开(公告)号：US11643413B2

公开(公告)日：2023-05-09

申请号：US16604494

申请日：2018-04-27

Applicant: UNIVERZITA PALACKEHO V OLOMOUCI

Inventor： Jana Bibova ,  Vaclav Mik ,  Marek Zatloukal ,  Lucie Plihalova ,  Jiri Gruz ,  Lukas Spichal ,  Karel Dolezal ,  Miroslav Strnad

IPC: C07D473/16 ,  A61K31/505 ,  A61K31/52 ,  A61K31/22 ,  A61Q19/08 ,  A61Q19/00 ,  A61P17/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P39/06 ,  A61K8/49

CPC classification number: C07D473/16 ,  A61K8/4953 ,  A61Q19/08

Abstract: The invention relates to N2,N6-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

公开(公告)号：US20230128322A1

公开(公告)日：2023-04-27

申请号：US17934107

申请日：2022-09-21

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Francesco Michelangelo Turrini ,  Kristina Rose Kesely ,  Antonella Pantaleo

IPC: A61K31/519 ,  A61K31/505 ,  A61K31/506 ,  A61K31/366 ,  A61K31/05 ,  A61K31/49 ,  A61K31/675 ,  A61K31/52 ,  A61K31/404 ,  A61K31/4706 ,  A61K45/06

Abstract: The disclosure relates to methods, compositions, and kits for treatment of parasite-mediated disease. In one embodiment, the disclosure relates to compounds, compositions, methods and kits for the treatment of malaria. In still another embodiment, the disclosure relates to a method for treating malaria comprising the use of a Syk kinase inhibitor.

公开(公告)号：US20230121768A1

公开(公告)日：2023-04-20

申请号：US17772888

申请日：2021-05-27

Applicant: NOVARTIS AG

Inventor： Zhenting GAO ,  Haibing GUO ,  Ming LI ,  Kun Chin LIU ,  Chunliang LU ,  Zhuming SUN ,  Yihui ZHU

IPC: C07D473/34 ,  A61P35/02 ,  A61K31/52 ,  C07D487/04 ,  A61K31/53 ,  C07D471/04 ,  A61K31/437

Abstract: The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by mixed lineage leukemia 1 (MLL1).