利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.031 秒)

    Ephenamine d-(-)-2-acetylamino-2-(4-acetoxyphenyl)acetate
    32.
    发明授权
    Ephenamine d-(-)-2-acetylamino-2-(4-acetoxyphenyl)acetate 失效
    乙烯衍生物D - （ - ） - 2-乙酰氨基-2-（4-乙酰氧基苯基）乙酸酯

    公开(公告)号：US3803213A

    公开(公告)日：1974-04-09

    申请号：US28940872

    申请日：1972-09-15

    申请人： BRISTOL MYERS CO

    发明人： WEBER A ,  BOUZARD D

    IPC分类号： C07B31/00 ,  C07B57/00 ,  C07C67/00 ,  C07C213/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07C101/12

    CPC分类号： C07B57/00

    摘要： RACEMIC 2-(P-HYDROXYPHENYL)GLYCINE IS EFFICIENTLY RESOLVED BY O,N-DI ACETYLATION FOLLOWED BY THE ADDITION OF ABOUT ONE MOLE OF LEVO-ERYTHROEPHENAMINE IN HOT ETHANOL, ACETONE OR ISOPROPYL ALCOHOL TO PRECIPITATE OR COOLING THE SUBSTANTIALLY PURE, CRYSTALLINE LEVO-ERYTHRO-EPHENAMINE SALT OF D-(-)-N-ACETYL-2-(P-ACETOXYPHENYL)-GLYCINE FROM WHICH THE SAME AMINE IS REMOVED BY EXTRACTION INTO METHYLENE CHLORIDE AT PH 10 FOLLOWED BY REMOVAL OF THE TWO ACETYL GROUPS BY HOT ACID HYDROLYSIS TO PRODUCE THE DESIRED D(-)-2-(P-HYDROXYPHENYL)GLYCINE.

    2-amino-2-(6-methoxy-2-naphthyl)-propionic acid and derivatives thereof
    33.
    发明授权
    2-amino-2-(6-methoxy-2-naphthyl)-propionic acid and derivatives thereof 失效
    2-氨基-2-（6-甲氧基-2-萘基） - 丙酸及其衍生物

    公开(公告)号：US3720708A

    公开(公告)日：1973-03-13

    申请号：US3720708D

    申请日：1971-10-01

    申请人： HALPERN O

    发明人： HALPERN O

    IPC分类号： C07C101/04 ,  C07C101/12

    CPC分类号： C07C229/36 ,  Y10S514/825 ,  Y10S514/916

    摘要： 2-(6-Methoxy-2-naphthyl)propionic acid is prepared by treating a compound represented by the formula: WHEREIN X is hydrogen, bromo or chloro and each of R and R1 is hydrogen and methyl, with palladium-on-charcoal, platinum oxide in an inert ogranic solvent under hydrogen or with Raney nickel in an inert organic solvent until 2-(6-methoxy-2naphthyl)propionic acid is formed. The product has antiinflammatory, analgesic and anti-pyretic activities.

    摘要翻译： 2-（6-甲氧基-2-萘基）丙酸是通过将下式表示的化合物：

    N-(2-hydroxyalkyl) sarcosine-n-oxides
    35.
    发明授权
    N-(2-hydroxyalkyl) sarcosine-n-oxides 失效
    N-（2-羟基烷基）恶唑烷-N-氧化物

    公开(公告)号：US3647868A

    公开(公告)日：1972-03-07

    申请号：US3647868D

    申请日：1967-10-18

    申请人： TEXTILANA CORP

    发明人： ERNST ROBERT

    IPC分类号： A61K8/40 ,  A61K8/44 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/10 ,  C07C291/04 ,  C07C101/12 ,  C07C101/30

    CPC分类号： C07C291/04 ,  A61K8/40 ,  A61K8/44 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/10

    摘要： WHERE R AND X HAVE THE ABOVE MEANING; AND Z IS AN ALKALI METAL PREFERABLY SODIUM OR POTASSIUM; THEREAFTER OXIDIZING THESE COMPOUNDS WITH HYDROGEN PEROXIDE AND, IF DESIRED, REPLACING THE ALKALI METAL Z WITH HYDROGEN, AMMONIA, OR A WATER SOLUABLE AMINE.

    R-X-CH2-CH(-OH)-CH2-N(-CH3)-CH2-COO-Z

    WHERE R AND X HAVE THE MEANING SET FORTH ABOVE TO YIELD N-(2-HYDROXYALKYL) SARCOSINE COMPOUNDS HAVING THE FORMULA:

    (R-X-CH2-)OXIRANE

    IN WHICH X IS EITHER OXYGEN OR A METHYLENE RADICAL AND R IS A HIGHER ALKYL GROUP, PREFERABLY UNSUBSTITUTED, HAVING 8-18 CARBON ATOMS WHEN X IS OXYGEN AND 6-16 CARBON ATOMS WHEN X IS A METHYLENE RADICAL, AND M IS AN ALKALI METAL, HYDROGEN, AMMONIA OR WATER SOLUBLE AMINE GROUP, THE COMPOUNDS BEING PREPARED BY REACTING AN ALKALI METAL SALT OF SARCOSINE WITH AN EPOXY COMPOUND HAVING THE FORMULA:

    R-X-CH2-CH(-OH)-CH2-N(=O)(-CH3)-CH2-COO-M

    AMINE OXIDE COMPOUNDS HAVING THE FORMULA: