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    Process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives
    34.
    发明授权
    Process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives 失效
    制备N-（2-甲基-4-氯苯基） - 甲脒衍生物的方法

    公开(公告)号：US4612395A

    公开(公告)日：1986-09-16

    申请号：US932830

    申请日：1978-08-11

    Applicant: Roland Dousse ,  Raoul Nebel

    Inventor： Roland Dousse ,  Raoul Nebel

    IPC: A01N37/52 ,  C07C123/00

    CPC classification number: A01N37/52

    Abstract: A process for the production of N-(2-methyl-4-chlorophenyl)-formamidine derivatives of formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms and R.sub.2 is an alkyl radical having 1 to 4 carbon atoms is disclosed which comprises reacting an N-substituted formamide with an inorganic acid chloride, such as phosphorus oxychloride, thionylchloride and phosgene, condensing the intermediate formed with o-toluidine and subsequently chlorinating the N-(2-methylphenyl)-formamidine derivative formed, all reaction steps involved in said process being carried out in the same solvent which is selected from the group of halogenated hydrocarbons.

    Abstract translation: 一种制备式（IMAGE）的N-（2-甲基-4-氯苯基） - 甲脒衍生物的方法，其中R 1为氢或具有1至4个碳原子的烷基，R 2为具有1至4个碳原子的烷基 原子被公开，其包括使N-取代的甲酰胺与无机酰氯如磷酰氯，亚硫酰氯和光气反应，将与邻甲苯胺形成的中间体缩合，随后将形成的N-（2-甲基苯基） - 甲脒衍生物， 所述方法中涉及的所有反应步骤均在与卤代烃类相同的溶剂中进行。

    Bis-amidine indene ketones, compositions containing same and method of use
    35.
    发明授权
    Bis-amidine indene ketones, compositions containing same and method of use 失效
    双脒茚酮，含有它们的组合物和使用方法

    公开(公告)号：US4371543A

    公开(公告)日：1983-02-01

    申请号：US270775

    申请日：1981-06-05

    Applicant: George C. Rovnyak

    Inventor： George C. Rovnyak

    IPC: A61K31/155 ,  A61K31/195 ,  C07C123/00

    CPC classification number: C07C257/18

    Abstract: Bis-amidine indene ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl; and R.sup.1 is hydrogen, lower alkyl, halogen, carboxy, trifluoromethyl, lower alkoxy, hydroxy or acyl, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.

    Abstract translation: 提供了具有结构的双脒茚酮，其中R是氢，低级烷基或芳基; R 1为氢，低级烷基，卤素，羧基，三氟甲基，低级烷氧基，羟基或酰基，及其酸加成盐。 此外，还提供了含有上述化合物的药物组合物及其用于治疗哺乳动物物种中的炎性病症的方法。

    Benzhydrylsulphinyl derivatives
    40.
    发明授权
    Benzhydrylsulphinyl derivatives 失效
    苯甲酰苯胺衍生物

    公开(公告)号：US4098824A

    公开(公告)日：1978-07-04

    申请号：US821534

    申请日：1977-08-03

    Applicant: Louis Lafon

    Inventor： Louis Lafon

    IPC: C07D233/20 ,  C07D295/08 ,  C07D295/088 ,  C07C123/00

    CPC classification number: C07C317/44 ,  C07D233/20 ,  C07D295/088

    Abstract: The invention provides the benzhydrylsulphinyl derivatives of the formula:(C.sub.6 H.sub.5).sub.2 CH--SO--(CH.sub.2).sub.n --R Iwhere n is 1, 2 or 3 and R is C(.dbd.O)NHOH, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, 2--.DELTA..sup.2 -imidazolinyl or NR.sub.1 R.sub.2 (where R.sub.1 is H or C.sub.1 --C.sub.3 -alkyl and R.sub.2 is H, C.sub.1 --C.sub.3 -alkyl, or CH.sub.2 CH.sub.2 OH, and R.sub.1 and R.sub.2 considered together can form, with the nitrogen atom to which they are bonded, a N-heterocyclic group of 5 to 7 ring members, which can be substituted and can contain a second hetero-atom such as O and N), and their addition salts. These products are useful in therapy for treating disturbances of the central nervous system.

    Abstract translation: 本发明提供下式的二苯甲基亚磺酰基衍生物：

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