公开(公告)号：US20210275473A1

公开(公告)日：2021-09-09

申请号：US17261255

申请日：2019-07-17

申请人： Yeda Research and Development Co. Ltd. ,  University of Duisburg-Essen

发明人： Anthony H. FUTERMAN ,  Tammar JOSEPH ,  Walter A. SHAW ,  Stephen W. BURGESS ,  Shengrong LI

IPC分类号： A61K31/167 ,  A61K31/133 ,  A61K31/164

摘要： Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

公开(公告)号：US11096968B2

公开(公告)日：2021-08-24

申请号：US16073282

申请日：2017-01-27

申请人： PROTOKINETIX INC.

发明人： Lachlan Grant Young

IPC分类号： A61K35/30 ,  A61K38/14 ,  A61K47/42 ,  A61P27/00 ,  A61K31/16 ,  A61K31/164 ,  C07K14/00 ,  C07K5/08 ,  C07K9/00 ,  A61K31/335 ,  C07K5/10

摘要： The present disclosure relates to an in vitro method for enhancing engraftment of neurosensory precursor cell comprising the step of contacting an isolated neurosensory precursor cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate thereof: (I).

公开(公告)号：US20210137857A1

公开(公告)日：2021-05-13

申请号：US16624747

申请日：2018-06-20

申请人： NEILOS S.R.L.

发明人： Umberto DI MAIO

IPC分类号： A61K31/164 ,  A61K36/53 ,  A23L33/105 ,  A23L33/175 ,  A23L29/00 ,  A61K31/198 ,  A61P25/28

摘要： The present invention relates to a composition for treatment and/or prevention of neurodegenerative diseases comprising at least a vegetable extract, an amide of a fatty acid and, optionally, a natural amino acid.

公开(公告)号：US20210113499A1

公开(公告)日：2021-04-22

申请号：US17074344

申请日：2020-10-19

申请人： University of Kentucky Research Foundation

发明人： Erhard Bieberich

IPC分类号： A61K31/164 ,  G01N33/68

摘要： The presently-disclosed subject matter generally relates to methods for diagnosing a subject with Alzheimer's Disease and treating the subject with an effective amount of a ceramide analogue. The presently disclosed matter further relates to methods for inhibiting protein binding to exosomes by administering ceramide analogues to a subject in need thereof. The presently disclosed matter also relates to methods of reducing the size of exosomes in a subject, comprising: administering an effective amount of a ceramide analogue to a subject in need thereof.

公开(公告)号：US10975035B2

公开(公告)日：2021-04-13

申请号：US16379487

申请日：2019-04-09

申请人： Recurium IP Holdings, LLC

发明人： Kevin Duane Bunker ,  Chuangxing Guo ,  Mark Charles Grier ,  Chad Daniel Hopkins ,  Joseph Robert Pinchman ,  Deborah Helen Slee ,  Peter Qinhua Huang ,  Mehmet Kahraman

IPC分类号： C07D213/89 ,  A61K31/164 ,  C07C233/05 ,  C07C233/14 ,  A61K31/27 ,  A61K31/13 ,  C07C211/38 ,  A61K31/444 ,  A61K45/06 ,  C07C317/30 ,  C07C215/42 ,  C07C233/06 ,  C07C233/09 ,  C07C233/13 ,  C07C233/23 ,  A61K31/145 ,  A61K31/16

摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

公开(公告)号：US10966937B2

公开(公告)日：2021-04-06

申请号：US15571314

申请日：2016-05-03

申请人： Cytometix, Inc.

发明人： Lane Brostrom ,  Henry Bordas-Murphy ,  John R. Falck

IPC分类号： A61K45/06 ,  A61K9/48 ,  A61K31/202 ,  A61P29/00 ,  A61K31/05 ,  A61K31/164 ,  A61K31/4468 ,  A61K31/381 ,  A61K31/135 ,  A61K31/16 ,  A61K31/197

摘要： The present invention provides a system enabling the oral delivery of therapeutics derived from polyunsaturated fatty acids (PUFAs), their metabolites and derivatives, including, eicosanoids, prostaglandins, prostacyclins, leukotrienes, resolvins, endocannabinoids, thromboxanes, epoxyeicosa-trienoic acids (EETs), hydroxyeicostetraenoic acids (HETEs), and CMX-020. The delivery system includes a vehicle comprising a purified docosahexaenoic acid (DHA) in triglyceride or ester form; a purified eicosapentaenoic acid (EPA) in triglyceride or ester form; a combination of DHA, EPA in either triglyceride or ester forms; or a modified DHA, EPA, or omega-3 fatty acid analog; and optionally, an antioxidant, a surfactant, a solubilizer, a stabilizer, a lubricant, or a pH/tonicity adjustment agent.

公开(公告)号：US10952977B2

公开(公告)日：2021-03-23

申请号：US16208394

申请日：2018-12-03

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  C07C237/08 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US20210015765A1

公开(公告)日：2021-01-21

申请号：US16919044

申请日：2020-07-01

申请人： PTC Therapeutics, Inc.

发明人： Paul MOLLARD ,  Peter GIANNOUSIS ,  Shazad SUCHIT ,  Mahmoud MIRMEHRABI

IPC分类号： A61K31/122 ,  C07C235/78 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07B57/00 ,  A61K31/164 ,  C07C215/08

摘要： Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20210008220A1

公开(公告)日：2021-01-14

申请号：US17041215

申请日：2019-03-26

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： May XIONG ,  Zhi LIU

IPC分类号： A61K47/61 ,  C08G83/00 ,  C08B37/16 ,  A61K31/164 ,  A61K31/4196 ,  A61K31/4412

摘要： Disclosed herein are a polyrotaxane conjugated metal chelators and selectively cleavable linkers. The compositions have prolonged plasma residence time, and upon contact with the appropriate chemical environment, are cleaved and then renally and fecally cleared.

公开(公告)号：US20200306212A1

公开(公告)日：2020-10-01

申请号：US16642178

申请日：2018-08-30

申请人： East Carolina University

发明人： Rukiyah T. Van Dross-Anderson ,  Rene Escobedo

IPC分类号： A61K31/164 ,  A61P35/00

摘要： Provided is a method of activating immune cells and/or an immune system response in a subject. The method may comprise administering to a subject an effective amount of a compound of Formula (I): or a prodrug, derivative, and/or salt thereof. In some embodiments, the method comprises contacting an immune cell with a compound of Formula (I) or a prodrug, derivative, and/or salt thereof. Also provided are compounds, compositions, and kits for activating immune cells and/or an immune system response in a subject.