公开(公告)号：US20220168475A1

公开(公告)日：2022-06-02

申请号：US17675343

申请日：2022-02-18

申请人： TERUMO KABUSHIKI KAISHA

发明人： Yuki UENO ,  Masanori KURAMOTO ,  Hiroki HOSONO ,  Hiromasa KOHAMA

IPC分类号： A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

摘要： A medical device that exhibits an excellent lubricating property includes: a substrate layer; and a surface lubricious layer formed on at least a part of the substrate layer, and containing a hydroxy group-containing compound selected from a group consisting of a non-volatile alcohol, a partially esterified product thereof, and a partially etherified product thereof, and soluble in water, and a hydrophilic copolymer containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from a group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group.

公开(公告)号：US20220142795A1

公开(公告)日：2022-05-12

申请号：US17580928

申请日：2022-01-21

申请人： BIOTYX MEDICAL (SHENZHEN) CO., LTD

发明人： Wenjiao LIN ,  Wenchao FU

IPC分类号： A61F2/82 ,  A61L31/02 ,  A61L31/14 ,  A61L31/16 ,  A61L31/10

摘要： An absorbable stent includes an absorbable matrix. The matrix includes a number of wave-shaped rings connected by connection units and arranged in an axial direction. The wave-shaped ring includes a number of waves arranged in a circumferential direction. A peak, a valley and a support connecting the peak and the valley form the wave. Two adjacent wave-shaped rings and the connection unit form a closed side supporting unit. The matrix has a volume of 4 μm to 40 μm per unit blood vessel area. The absorbable stent has sufficient radial supporting strength of no less than 55 kPa for clinical applications. Moreover, the volume of the matrix per unit blood vessel area is less than volumes of existing stents. When the absorbable stent and existing stents are made of the same material, the absorbable stent has a shorter degradation and absorption cycle.

公开(公告)号：US20220135650A1

公开(公告)日：2022-05-05

申请号：US17435325

申请日：2020-03-02

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： James R. Swartz ,  Maya Nagasawa

IPC分类号： C07K14/705 ,  A61L31/10

摘要： Compositions and methods are provided relating to engineered CD47 extracellular domain (ECD) proteins.

公开(公告)号：US20220134695A1

公开(公告)日：2022-05-05

申请号：US16584704

申请日：2019-09-26

申请人： TurnCare, Inc.

发明人： Rafael Paolo Squitieri ,  Robert Charles Deutsch ,  Steven Bruce Frazier ,  Robert Loiacono ,  Linda Seaman ,  Erica Kelly

IPC分类号： B29D22/02 ,  A61F5/32 ,  A61L31/10 ,  A61F5/34 ,  A61L31/14

摘要： Introduced here are methods, apparatuses, and systems for mitigating the contact pressure applied to a human body by the surface of an object, such as a chair, bed, or table. A pressure-mitigation apparatus can include a series of chambers whose pressure can be individually varied. When placed between a patient and a contact surface, a controller can vary the contact pressure on the human body by controllably inflating one or more chambers, deflating one or more chambers, or any combination thereof. By monitoring the pressure in each chamber over time, the controller can also gain an enhanced understanding of movement(s) performed by the human body when positioned on the pressure-mitigation apparatus.

公开(公告)号：US20220134068A1

公开(公告)日：2022-05-05

申请号：US17431230

申请日：2020-02-14

申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  RAMBAM MED-TECH LTD.

发明人： Eyal ZUSSMAN ,  Gilad AMIEL ,  Idan SHLOMI ,  Ahmad KABHA

IPC分类号： A61M31/00 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16 ,  A61F2/04

摘要： Compositions comprising electrospun fibers and active (e.g. pharmaceutical) agents encapsulated thereto are provided. Further, articles and methods of use of the fibers, including, but not limited to coating of medical tubing, are provided.

公开(公告)号：US20220126000A1

公开(公告)日：2022-04-28

申请号：US17520561

申请日：2021-11-05

申请人： Bard Shannon Limited

发明人： Orahn Preiss-Bloom ,  Guy Tomer ,  Amir Hadid ,  Alon Polakewicz ,  Ariel Maizler ,  Denis Kramarenko ,  Daniella Goder ,  Danny Yosufov

IPC分类号： A61L31/10 ,  A61L31/12 ,  A61L31/14 ,  C08L89/00

摘要： A mesh-based composition comprising a cross-linkable protein or polypeptide and one or more cross-linking materials according to at least some embodiments. The mesh-based composition may comprise a self-adhering surgical mesh which requires no additional fixation while at the same time minimizes adhesions. The mesh may be in the form of a composite mesh featuring a foamed composition of the cross-linkable protein and a non-toxic material that induces cross-linking of the cross-linkable protein. The composite mesh may be in a sheet-like form.

公开(公告)号：US20220125998A1

公开(公告)日：2022-04-28

申请号：US17432579

申请日：2020-02-18

申请人： LES LABORATOIRES OSTEAL MEDICAL

发明人： Daniel BLANQUAERT ,  Amélie LEROUX ,  Véronique MIGONNEY

IPC分类号： A61L31/04 ,  A61L31/14 ,  A61L31/10 ,  A61L15/26 ,  A61L15/64 ,  C08L67/04 ,  C09D125/18 ,  D04H1/435 ,  D04H1/45 ,  A61L15/18

摘要： Membrane, used in particular for regenerating periodontal ligament, preventing the formation of adhesions or the regeneration and reconstruction of tissue, including at least one layer of fabric (N1) made of fibres (F) produced from at least one polymer. The fibres (F) are free of sizing, the layer of fabric (N1) has a non-woven arrangement of fibres disposed in a random or aligned manner, and the fibres (F) are coated with PolyNaSS (polystyrene sodium sulfonate).

公开(公告)号：US20220117230A1

公开(公告)日：2022-04-21

申请号：US17457186

申请日：2021-12-01

申请人： Nevada Naturals Inc.

发明人： Anthony J. Sawyer ,  Richard F. Stockel

IPC分类号： A01N47/44 ,  A01N43/16 ,  A01N37/36 ,  A61L31/14 ,  A61L27/52 ,  A61L29/16 ,  A61L15/20 ,  A61L31/10 ,  A61L31/16 ,  A61L29/08 ,  A61L17/00 ,  A61L29/14 ,  A61L27/54 ,  A61L15/60 ,  A61L27/34 ,  A61L15/46

摘要： Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

公开(公告)号：US11266768B2

公开(公告)日：2022-03-08

申请号：US15039136

申请日：2014-11-26

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Mark Grinstaff ,  Jonah Andrew Kaplan ,  Julia Wang

IPC分类号： A61K9/26 ,  A61L31/14 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61K9/51 ,  A61K9/50

摘要： The disclosure provides a drug delivery device that can release a drug or other molecule of interest in response to application of a mechanical force, such as tension, and methods of use thereof. The present disclosure provides a tension-responsive drug delivery device by exploiting a difference in mechanical properties between a drug-loaded core material and a supertiydrophobic barrier coating consisting of interconnected micro- and nano-sized particles formulated via the electrospraying of a mixture of biocompatible polymers.

公开(公告)号：US11260150B2

公开(公告)日：2022-03-01

申请号：US16726750

申请日：2019-12-24

申请人： Tangible Science, Inc.

发明人： Karen Havenstrite ,  Victor W. McCray ,  Brandon M. Felkins ,  Paul Cook

IPC分类号： A61L29/14 ,  A61L27/52 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L15/60 ,  A61L27/34 ,  A61L31/16 ,  A61L15/46

摘要： Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions.