-
公开(公告)号:US12188016B2
公开(公告)日:2025-01-07
申请号:US16626395
申请日:2018-06-27
Inventor: Ernest Guccione , Dave Keng Boon Wee , Antonio Bertoletti
IPC: C12N15/11 , A61K31/7088 , A61K35/17 , A61P35/00 , C12N15/113
Abstract: The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene.
-
公开(公告)号:US20240424491A1
公开(公告)日:2024-12-26
申请号:US18703263
申请日:2022-10-12
Applicant: Agency for Science, Technology and Research
Inventor: Xuezhi BI , Ruige WU , Pinhui LEE , Ke GAN
IPC: B01L3/00
Abstract: A microfluidic chip (12) for sample preparation and a sample preparation system (10) are provided. The microfluidic chip (10) includes: a chip body (14) and a plurality of injection ports (16, 18, 24, 30, 36, 38, 40) provided in the chip body (14). A plurality of chambers (20, 26, 32) and a plurality of mixers (22, 28, 34) are provided in the chip body (14). A first chamber (20) is configured to receive a sample via a first injection port (16) and a reducing agent via a second injection port (18). A first mixer (22) in fluid communication with the first chamber (20) is operable to mix the sample and the reducing agent from the first chamber (20) to produce a denatured and reduced sample. A second chamber (26) in fluid communication with the first mixer (22) is configured to receive an alkylating agent via a third injection port (24). A second mixer (28) in fluid communication with the second chamber (26) is operable to mix the denatured and reduced sample with the alkylating agent to produce an alkylated sample. A third chamber (32) in fluid communication with the second mixer (28) is configured to receive a protein precipitation solution via a fourth injection port (30). A third mixer (34) in fluid communication with the third chamber (32) is operable to mix the alkylated sample with the protein precipitation solution to produce a precipitated sample. A reaction chamber (42) in fluid communication with the third mixer (34) is provided in the chip body (14), the reaction chamber (42) being configured to receive a washing buffer via a fifth injection port (36), a digestion buffer via a sixth injection port (38) and an elution buffer via a seventh injection port (40). A depth filter (43) is received in the reaction chamber (42). A first discharge port (44) and a second discharge port (46) are provided in the chip body (14) in fluid communication with the reaction chamber (42). The first discharge port (44) is operable to discharge waste from the reaction chamber (42) and the second discharge port (46) is operable to discharge a prepared sample.
-
公开(公告)号:US20240360420A1
公开(公告)日:2024-10-31
申请号:US18287710
申请日:2022-04-21
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Steve Kah-Weng Oh , Shaul Reuveny , Tin Lun Lam , Jonathan Yuin Han Loh
CPC classification number: C12N5/0696 , C12N15/86 , C12N2506/1307 , C12N2531/00 , C12N2533/30 , C12N2533/50 , C12N2760/18843
Abstract: Disclosed is a method of reprogramming somatic cells into induced pluripotent stem cells (iPSCs). Also disclosed is a method of producing, selecting, expanding, characterizing, and differentiating iPSCs. Further disclosed is a method of reprogramming somatic cells selected from the group consisting of fibroblasts IMR90, fibroblasts HFF-01, PBMC, CD3+ T cells and CD34+ hematopoietic stem cells (HSCs) into iPSCs.
-
公开(公告)号:US12128063B2
公开(公告)日:2024-10-29
申请号:US17494708
申请日:2021-10-05
Applicant: International Business Machines Corporation , Agency for Science, Technology and Research
Inventor: James L. Hedrick , Yi Yan Yang , Agnes Mari Kuroki , Jiayu Eunice Leong , Wei Ping Eddy Tan
IPC: A61K31/795 , A61P31/14 , C08G64/02
CPC classification number: A61K31/795 , A61P31/14 , C08G64/025
Abstract: A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.
-
公开(公告)号:US20240327500A1
公开(公告)日:2024-10-03
申请号:US18579482
申请日:2022-07-06
Applicant: National University of Singapore , National University Hospital (Singapore) Pte Ltd , Agency for Science, Technology and Research
Inventor: Paul Anthony Macary , Saket Jhajharia , Seng Lim , Qingfeng Chen , Fritz Lai
CPC classification number: C07K16/082 , A61P31/20 , G01N33/58 , G01N33/6854 , A61K2039/505 , C07K2317/14 , C07K2317/32 , C07K2317/565 , C07K2317/76 , G01N2333/02
Abstract: The present invention relates to isolated and engineered human antibodies that specifically bind to at least one conformational (non-linear) epitope of HBsAg and neutralize hepatitis B virus infection, methods for producing the same, and uses thereof in treating human HBV infection.
-
公开(公告)号:US20240307842A1
公开(公告)日:2024-09-19
申请号:US18576009
申请日:2022-07-20
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Yee Fun LIM , Yang XU , Jian Wei Jayce CHENG , Swee Liang WONG , Vijila CHELLAPPAN , Jatin KUMAR , Daniil BASH , Tonio BUONASSISI , Kedar HIPPALGAONKAR
IPC: B01J19/00 , B01J4/00 , B01J14/00 , B01J19/24 , B29C64/314 , B29C64/393 , B33Y40/00 , B33Y50/02
CPC classification number: B01J19/0033 , B01J4/008 , B01J14/00 , B01J19/24 , B29C64/314 , B29C64/393 , B33Y40/00 , B33Y50/02 , B01J2204/002 , B01J2219/00164 , B01J2219/00202 , B01J2219/00243
Abstract: The present disclosure generally relates to a flow reactor system (100) and a flow reaction method (200). The flow reactor system (100) comprises liquid pumps (110) for communicating liquid reagents based on a set of flow conditions, a fluid pump (200) for communicating a carrier fluid that is immiscible with the liquid reagents; a fluidic mixer (130) for mixing the liquid reagents into a liquid mixture, a measurement device (150) for measuring properties of liquid plugs (140) discharged from an outlet (136) of the fluidic mixer (130); and a control module configured for controlling the liquid pumps (110) and adjusting the flow conditions based on the measured properties of the liquid plugs (140), wherein the liquid plugs (140) are representative of different flow conditions.
-
公开(公告)号:US20240305018A1
公开(公告)日:2024-09-12
申请号:US18284051
申请日:2022-03-29
Inventor: Po Shin Francois Chin , - Nasimuddin , Bo Shi , Xianming Qing
CPC classification number: H01Q23/00 , H01Q3/36 , H01Q5/42 , H01Q21/065
Abstract: A phased array antenna that maximizes antenna gain and minimizes or avoids grating/side lobes issues. The phased array antenna includes a receiver antenna array including one or more groups of receiver radiating elements, where each group of receiver radiating elements includes a first receiver subarray of receiver radiating elements and a second receiver subarray of receiver radiating elements. The phased array antenna further includes receiver core chips, including, for each of the one or more groups of receiver radiating elements, a first receiver core chip associated with the first receiver subarray and a second receiver core chip associated with the second receiver subarray. Additionally, the phased array antenna includes receiver feeding networks, including, for each of the one or more groups of receiver radiating elements, a first receiver feeding network including first feed lines and a second receiver feeding network including second feed lines.
-
公开(公告)号:US20240301550A1
公开(公告)日:2024-09-12
申请号:US18657569
申请日:2024-05-07
Applicant: Agency for Science, Technology and Research
Inventor: Swee Liang Wong , Yee Fun Lim , Dongzhi Chi
IPC: C23C16/30 , C23C16/44 , C23C16/448 , C23C16/455
CPC classification number: C23C16/305 , C23C16/4401 , C23C16/4481 , C23C16/455
Abstract: A method of forming a transition metal dichalcogenide layer on a substrate is provided. The method may include providing a transition metal oxide, a chalcogen source, a non-gaseous chalcogen scavenger, and a substrate, wherein the substrate is disposed downstream of the transition metal oxide and the chalcogen source, and wherein the non-gaseous chalcogen scavenger is disposed in proximity to the transition metal oxide; generating vapors of the transition metal oxide and vapors of the chalcogen source, wherein the non-gaseous chalcogen scavenger reacts preferentially with the vapors of the chalcogen source; disposing the vapors generated from the transition metal oxide and the chalcogen source on the substrate; and reacting the vapors of the transition metal oxide and the chalcogen source on the substrate to obtain the transition metal dichalcogenide layer on the substrate. An arrangement for forming a transition metal dichalcogenide layer on a substrate is also provided.
-
公开(公告)号:US20240287380A1
公开(公告)日:2024-08-29
申请号:US18571298
申请日:2022-06-15
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Weng Heng Liew , Kui Yao , Shuting Chen
CPC classification number: C09K11/025 , C09K11/565 , C09K11/57 , C09K11/58 , H04R3/04 , H05B33/14 , H05B44/00 , H04R2430/01
Abstract: Devices and method for synchronized light and sound emission are disclosed. The device comprises: a first electrode layer; a second electrode layer; and a composite material layer disposed between the first electrode layer and the second electrode layer, the composite material layer having an electromechanical active matrix and an electroluminescent component; and wherein the electroluminescent component comprises a plurality of particle sets dispersed in the electromechanical active matrix, each particle set being continuous and having two ends each in contact with a respective one of the first and second electrode layers.
-
450.
公开(公告)号:US20240278207A1
公开(公告)日:2024-08-22
申请号:US18568156
申请日:2022-06-06
Inventor: Dinesh Mullangi , Zeyu Deng , Yuxiang Wang , John Wang , Pieremanuele Canepa , Dan Zhao , Anthony Kevin Cheetham , Fengxia Wei
CPC classification number: B01J20/226 , B01D53/04 , B01J20/28061 , B01J20/28064 , B01J20/3483 , B01J20/3491 , C07F5/061 , C07F15/02 , B01D2257/104 , B01D2257/504
Abstract: Discloses herein is an activated metal-organic framework of formula as defined in the application, and the metal organic framework has a BET surface area of from 250 to 1,000 m2/g as obtained from a 298 K CO2 sorption isotherm. In a particular embodiment, the activated metal-organic framework is aluminium formate (Al(HCOO)3) or vanadium formate (V(HCOO)3).
-
-
-
-
-
-
-
-
-