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    Method for preparation of ceftiofur and salts thereof
    452.
    发明授权
    Method for preparation of ceftiofur and salts thereof 失效
    头孢噻呋及其盐的制备方法

    公开(公告)号：US07335767B2

    公开(公告)日：2008-02-26

    申请号：US10694619

    申请日：2003-10-27

    Applicant: Om Dutt Tyagi ,  Santosh Kumar Richhariya ,  Rajesh Kumar Ramchandra Pawar

    Inventor： Om Dutt Tyagi ,  Santosh Kumar Richhariya ,  Rajesh Kumar Ramchandra Pawar

    IPC: C07D501/36

    CPC classification number: C07D501/00

    Abstract: A process for preparation of ceftiofur sodium of formula (Ib) possessing high stability and having purity of more than 97% and substantially free of impurities, is disclosed. The process comprises: i) reacting cefotaxime or its salts or its esters of formula (VI) wherein R3 is hydrogen, an alkali or alkaline earth metal, or an easily hydrolysable ester, with thiofuroic acid, employed in a molar proportion of 1.5 to 3.0 moles per mole of compound (VI), in the presence of acetonitrile as solvent and in the presence of large excess of methanesulfonic acid, employed in molar proportions of 12 to 18 moles per mole of compound (VI), and at a temperature of between −5° C. to 30° C. to give after necessary neutralization of the alkali or alkaline earth metal or removal of the ester group of the 4-carboxylic acid function, wherever applicable, ceftiofur of formula (Ia), possessing high stability and having purity of more than 97% and substantially free of impurities; ii) converting the ceftiofur of formula (Ia) thus obtained to its salt with an organic amine by treating a solution of ceftiofur in a mixture of water and a water-miscible organic solvent with an organic amine, at a temperature ranging from −10° C. to 10° C.; iii) reacting of the amine salt thus obtained with a sodium metal carrier in a mixture of water and water-miscible organic solvent and in presence of sodium hydrogen sulfite to give ceftiofur sodium of formula (Ib).

    Abstract translation: 公开了制备具有高稳定性和纯度大于97％且基本上不含杂质的式（Ib）头孢噻呋钠的方法。 该方法包括：i）将头孢噻肟或其盐或其其中R 3为氢的式（VI）的酯，碱金属或碱土金属或易水解的酯与硫代呋喃酸反应， 摩尔比例为1.5-3.0摩尔/摩尔化合物（Ⅵ），在乙腈作为溶剂的存在下，在大量过量的甲磺酸的存在下，摩尔比例为12至18摩尔/摩尔化合物（Ⅵ ），并且在-5℃至30℃的温度下进行，必要时中和碱金属或碱土金属或除去4-羧酸官能团的酯基（如果适用的话），式 （Ia），具有高稳定性，纯度大于97％，基本上不含杂质; ii）通过在-10℃的温度范围内用有机胺处理水与水混溶性有机溶剂的混合物中的头孢噻肟溶液，将有机胺衍生的式（Ia）头孢噻吩转化为其盐 ℃至10℃。 iii）将由此得到的胺盐与水和水混溶性有机溶剂的混合物中的钠金属载体与亚硫酸氢钠的混合物反应，得到式（Ib）的头孢噻肟钠。

    Method and System for Initiating a Remote Trace Route
    453.
    发明申请
    Method and System for Initiating a Remote Trace Route 有权
    启动远程跟踪路由的方法和系统

    公开(公告)号：US20080031145A1

    公开(公告)日：2008-02-07

    申请号：US11462587

    申请日：2006-08-04

    Applicant: Randall P.J. Ethier ,  Rajesh Kumar

    Inventor： Randall P.J. Ethier ,  Rajesh Kumar

    IPC: H04J3/14 ,  H04L12/56

    CPC classification number: H04L29/06027 ,  H04L41/12 ,  H04L43/00 ,  H04L43/0829 ,  H04L43/0852 ,  H04L43/087 ,  H04L45/26 ,  H04L45/28 ,  H04L65/80

    Abstract: A method for initiating a remote trace route includes establishing a communication session between a first endpoint and a second endpoint. The method also includes detecting at the first endpoint a quality impairment in a communication sent from the second endpoint. In response to detecting the quality impairment, the method includes sending a request from the first endpoint to the second endpoint for the second endpoint to initiate a trace route from the second endpoint to the first endpoint. Upon receiving the request at the second endpoint, the method includes initiating a trace route from the second endpoint to the first endpoint.

    Abstract translation: 用于发起远程跟踪路由的方法包括在第一端点和第二端点之间建立通信会话。 该方法还包括在第一端点处检测从第二端点发送的通信中的质量损害。 响应于检测到质量损害，该方法包括向第二端点发送从第一端点到第二端点的请求以发起从第二端点到第一端点的跟踪路由。 在第二端点接收到请求时，该方法包括发起从第二端点到第一端点的跟踪路由。

    Method of and apparatus for cross-platform core dumping during dynamic binary translation
    459.
    发明授权
    Method of and apparatus for cross-platform core dumping during dynamic binary translation 失效
    动态二进制翻译期间跨平台核心转储的方法和装置

    公开(公告)号：US07149929B2

    公开(公告)日：2006-12-12

    申请号：US10647142

    申请日：2003-08-25

    Applicant: Rajesh Kumar Chaurasia

    Inventor： Rajesh Kumar Chaurasia

    IPC: G06F11/00

    CPC classification number: G06F11/366

    Abstract: A core file derived from an application crash is created. The application belongs to a source platform and is run on a target platform. The application is emulated on the target platform. In response to the crash occurring, detecting whether the crash corresponds to the failure of a process corresponding to the emulated application. The crash process is mediated by intercepting information relating to the failure of the emulated application and writing a core file corresponding to the failure of the emulated application running on the source platform. A dynamic binary translator performs the steps and debugs an emulated application as if it had crashed and dumped a core file on its native platform.

    Abstract translation: 创建从应用程序崩溃导出的核心文件。 该应用程序属于源平台，并在目标平台上运行。 应用程序在目标平台上仿真。 响应于发生的崩溃，检测崩溃是否对应于与仿真应用程序相对应的进程的故障。 崩溃过程是通过拦截与仿真应用程序的故障相关的信息并编写与在源平台上运行的仿真应用程序的故障相对应的核心文件来进行的。 动态二进制转换器执行步骤并调试仿真应用程序，就像它在其本机平台上崩溃并转储核心文件一样。

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