公开(公告)号：US20020095029A1

公开(公告)日：2002-07-18

申请号：US10039069

申请日：2002-01-02

Applicant: Academia Sinica, a Taiwan corporation

Inventor： Chien-Chung Cheng ,  Wen Jwu Wang

IPC: C12Q001/68 ,  C07H021/04 ,  C07F019/00

CPC classification number: C07H21/00 ,  C07D471/22 ,  C07D498/22 ,  C07D513/22

Abstract: This invention relates to a metal complex of formula (I). The metal complex is capable of cleaving a bulge-containing nucleic acid at the bulge site with high specificity.

Abstract translation: 本发明涉及式（I）的金属络合物。 金属络合物能够以高特异性在凸起部位切割含有凸起的核酸。

公开(公告)号：US6140503A

公开(公告)日：2000-10-31

申请号：US236683

申请日：1999-01-25

Applicant: Jiann T'suen Lin ,  Iuan-Yuan Wu ,  K. R. Justin Thomas

Inventor： Jiann T'suen Lin ,  Iuan-Yuan Wu ,  K. R. Justin Thomas

IPC: C07F15/00 ,  C07F15/02 ,  C07F15/04 ,  C07F17/02 ,  C07D213/04 ,  C07D207/00 ,  C07D307/02 ,  C07D409/00

CPC classification number: C07F17/02 ,  C07F15/0046 ,  C07F15/0086 ,  C07F15/02 ,  C07F15/04

Abstract: A compound consisting of three aromatic moieties respectively bonded to a methyl carbocation, and a counterion; wherein each of the three aromatic moieties is optionally substituted with an electron-donating group, at least one of the three aromatic moieties is bonded to a metal complex moiety, either directly or through a linker, and the methyl carbocation, the aromatic moieties, the metal complex moiety, and the linker form a conjugated system.

Abstract translation: 由分别与甲基碳阳离子键合的三个芳香部分和抗衡离子组成的化合物; 其中三个芳族部分中的每一个任选被供电子基团取代，三个芳族部分中的至少一个直接或通过连接体键合到金属络合物部分，并且甲基碳阳离子，芳族部分， 金属络合物部分，并且连接体形成共轭体系。

公开(公告)号：US4890084A

公开(公告)日：1989-12-26

申请号：US192991

申请日：1988-05-12

Applicant: Li Chu

Inventor： Li Chu

IPC: G01B7/24

CPC classification number: G01B7/24 ,  Y10S33/13

Abstract: Side-by-side inductor coils are wound in a single layer around a thin flat tubular frame. The frame has a closed end portion and is mounted on an insulative base sheet. An elongated thin magnetic core is cantilevered from a insulative connecting rod and normally is positioned inside the frame approximately centered between the two coils. The end portion of the connecting rod remote from the frame is secured to the base sheet. The base sheet can be applied to a specimen to be stress tested and is formed to withstand elongation and compression. Lengthwise sliding of movement of the magnetic core in the coil frame due to stress applied to the specimen indicates the strain of the specimen.

Abstract translation: 并排电感线圈围绕薄平的管状框架缠绕在单层中。 框架具有封闭的端部，并且安装在绝缘基片上。 细长的薄磁芯由绝缘连接杆悬臂连接，通常位于框架内部，大致居中在两个线圈之间。 远离框架的连杆的端部固定在基片上。 基片可以应用于要进行应力测试的试样，并且形成为能够承受伸长和压缩。 由于施加在试样上的应力，磁芯在线圈框架中的纵向滑动指示试样的应变。

公开(公告)号：US4678847A

公开(公告)日：1987-07-07

申请号：US846795

申请日：1986-04-01

Applicant: Yun-xiang Zhang ,  Xing-yi Dai ,  Zhi-kang Lu ,  Sen Zeng

Inventor： Yun-xiang Zhang ,  Xing-yi Dai ,  Zhi-kang Lu ,  Sen Zeng

IPC: C08F2/06 ,  C08F210/02 ,  C08F214/26 ,  C08F2/14

CPC classification number: C08F214/265 ,  C08F210/02 ,  C08F2438/01

Abstract: The present invention relates to the process for preparing terpolymer of tetrafluoroethylene (TFE), ethylene (E), and a third monomer. According to the present invention, dicarbonate peroxide is used as initiator, 1,1,2-trichloro-1,2,2-trifluoro-ethane as the reaction medium and compounds of molecular formula C.sub.n R.sub.2n+2, wherein, n=0,1, or 2;R=H, Cl or F, are gaseous chain telomeric agents to control the average molecular weight of copolymers, the formula of third monomer is CF.sub.2 XCOCF.sub.2 X' or ##STR1## wherein X=X'=Cl or F, R.sub.1 =CF.sub.3 or CH.sub.3,R.sub.2 =CF.sub.3, CH.sub.3 or H, and R.sub.3 =H or F, usually the molar ratio of TFE to E is from 60:40 to 40:60 with the content of the third monomer being from 0.1% to 10%, based on the total molar amount of TFE and E.

Abstract translation: 本发明涉及制备四氟乙烯（TFE），乙烯（E）和第三单体三元共聚物的方法。 根据本发明，使用二碳酸过氧化物作为引发剂，1,1,2-三氯-1,2,2-三氟乙烷作为反应介质和分子式CnR2n + 2的化合物，其中n = 0,1 或2; R = H，Cl或F是用于控制共聚物的平均分子量的气态链端粒剂，第三单体的式为CF 2 XCOCF 2 X'或其中X = X'= Cl或F，R 1 = CF3或CH3，R2 = CF3，CH3或H，R3 = H或F，通常TFE与E的摩尔比为60:40至40:60，第三单体的含量为0.1％至10 ％，基于TFE和E的总摩尔量。

公开(公告)号：US12227546B2

公开(公告)日：2025-02-18

申请号：US16970350

申请日：2019-02-12

Applicant: Academia Sinica

Inventor： Yuh-Shan Jou ,  Yaw-Dong Lang ,  Hsi-Wen Yeh

IPC: C12N15/00 ,  A61K48/00 ,  C07K14/47 ,  C12N15/63 ,  A61K38/00

Abstract: An isolated nucleic acid encoding a C-terminal fragment of paraspeckle component 1 (PSPC1) is disclosed. The C-terminal fragment of the PSPC1 comprises an extension of more than 10 but no greater than 131 amino acid residues with its C-terminal amino acid identical to the C-terminus of the PSPC1 sequence SEQ ID NO: 3 and exhibits a biological activity against tumor cells. The tumor cells are associated with either PSPC1 or protein tyrosine kinase 6 (PTK6), or both. The anti-tumor activity is at least one selected from the group consisting of: (a) suppressing tumor cell growth; (b) suppressing tumor cell progression; (c) suppressing tumor cell metastasis; (d) decreasing PSPC1 expression; and (e) decreasing oncogenic PTK6 expression in cytoplasm. Also disclosed is a peptide comprising a C-terminal fragment sequence of PSPC1. A reagent kit and method for predicting tumor progression, metastasis, and prognosis in a cancer patient are also disclosed.

公开(公告)号：US20250034519A1

公开(公告)日：2025-01-30

申请号：US18896384

申请日：2024-09-25

Applicant: The Regents of the University of California ,  Academia Sinica

Inventor： Cheemeng TAN ,  Luis E. CONTRERAS LLANO ,  Che-Ming J. HU

IPC: C12N5/07 ,  C12N13/00 ,  G01N33/483

Abstract: Assembly of a synthetic polymer network inside cells is described that renders the cells incapable of dividing. The resulting cells can retain functions, including for example, cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. The cells can also acquire new abilities to resist stressors that otherwise kill natural cells.

公开(公告)号：US20250028163A1

公开(公告)日：2025-01-23

申请号：US18909323

申请日：2024-10-08

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US12144910B2

公开(公告)日：2024-11-19

申请号：US17604318

申请日：2020-04-16

Applicant: ACADEMIA SINICA

Inventor： You-Di Liao ,  Dan-Wei Wang ,  Eden Wu ,  Shih-Han Wang ,  Wen-Hung Tang

IPC: A61L27/54 ,  A61L29/16 ,  A61L31/16

Abstract: The present invention pertains to methods of coating antimicrobial peptides on the biomaterial and the biomaterial coated thereby. The coating solution described herein comprises one or more antimicrobial peptides (AMPs) dissolved in a buffer containing an anionic surfactant, wherein the AMPs are amphipathic and cationic.

公开(公告)号：US12116407B2

公开(公告)日：2024-10-15

申请号：US17269991

申请日：2019-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Pei-Shan Sung ,  Ming-Ting Huang ,  An-Suei Yang ,  Chung-Ming Yu

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  A61P31/20

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.

公开(公告)号：US20240331862A1

公开(公告)日：2024-10-03

申请号：US18622407

申请日：2024-03-29

Applicant: National Taiwan University ,  National Taiwan University Hospital ,  Academia Sinica ,  National Tsing Hua University

Inventor： Shau-Ping LIN ,  Ruey-Meei WU ,  Frederick Kin Hing Phoa ,  Ming-Che KUO ,  Yi-Tzang TSAI ,  Jing-Wen HUANG ,  Yan-Han LIN ,  Hsiang-Hsuan LIN WANG ,  Chia-Lang HSU ,  Ya-Fang HSU ,  Pin-Jui KUNG

IPC: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6883 ,  G01N33/68 ,  G16H10/60

CPC classification number: G16H50/20 ,  C12Q1/6806 ,  C12Q1/6883 ,  G01N33/6896 ,  G16H10/60 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2333/4706 ,  G01N2333/521 ,  G01N2333/575 ,  G01N2333/7051 ,  G01N2333/70596 ,  G01N2333/726 ,  G01N2333/775 ,  G01N2333/82 ,  G01N2333/90203 ,  G01N2333/91057 ,  G01N2333/91091 ,  G01N2333/91215 ,  G01N2333/96419 ,  G01N2333/99 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: The present invention provides a data analytic scheme for screening biomarkers for differential diagnosis of the status of Parkinson's disease, Parkinson's disease with mild cognitive impairment, Parkinson's disease dementia, Alzheimer's disease, and/or multiple system atrophy, the methodology implementing the same and the results of the screening thereof. Biomedical Oriented Logistic Dantzig Selector (BOLD Selector) was developed to identify candidate microRNAs and extracellular vesicle proteins effective at discerning between any two of the above mentioned disease categories from profiling results. The prediction models are finalized by establishing logistic regression formula for each pair of patient group differentiation.