公开(公告)号：US10562955B2

公开(公告)日：2020-02-18

申请号：US15842178

申请日：2017-12-14

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Elin Gunneriusson ,  Malin Lindborg ,  Lars Abrahmsen ,  John Löfblom ,  Torbjörn Gräslund ,  Johan Seijsing

IPC: C07K14/745 ,  C07K14/735 ,  C07K14/31 ,  C07K14/74 ,  C07K14/435 ,  A61K38/00

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2 X3 X4 AX6 X7 EIRWLPNL X16X17 X18 QRX21 AFIX25 X26LX28 X29. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

公开(公告)号：US10556933B2

公开(公告)日：2020-02-11

申请号：US15238184

申请日：2016-08-16

Applicant: Affibody AB

Inventor： Lars Abrahmsén ,  Nina Herne ,  Christofer Lendel ,  Joachim Feldwisch

IPC: C40B40/10 ,  C07K14/31 ,  C12N15/10 ,  C07K1/04 ,  G01N33/68

Abstract: Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO: 2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.

公开(公告)号：US20190262481A1

公开(公告)日：2019-08-29

申请号：US16145115

申请日：2018-09-27

Applicant: GENERAL ELECTRIC COMPANY ,  AFFIBODY AB

Inventor： Faisal Ahmed Syud ,  Brian Duh-Lan Lee ,  Rong Zhang ,  Peter Brian Iveson ,  Paul Schaffer ,  Tove Simonsson ,  Elin Gunneriusson ,  Fredrik Frejd ,  Lars Abrahmsen ,  Joachim Feldwisch ,  Nina Herne ,  Christofer Lendel

IPC: A61K51/08 ,  C07K14/71

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

公开(公告)号：US10159760B2

公开(公告)日：2018-12-25

申请号：US15083424

申请日：2016-03-29

Applicant: General Electric Company ,  AFFIBODY AB

Inventor： Faisal Ahmed Syud ,  Brian Duh-Lan Lee ,  Rong Zhang ,  Peter Brian Iveson ,  Paul Schaffer ,  Tove Simonsson ,  Elin Gunneriusson ,  Fredrik Frejd ,  Lars Abrahmsen ,  Joachim Feldwisch ,  Nina Herne ,  Christofer Lendel

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  C07K14/71

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

公开(公告)号：US20180312565A1

公开(公告)日：2018-11-01

申请号：US15770956

申请日：2016-10-28

Applicant: AFFIBODY AB

Inventor： Elisabet Wahlberg ,  Elin Gunneriusson

IPC: C07K14/705 ,  C07K14/47 ,  A61P35/00 ,  A61K47/42

CPC classification number: C07K14/70532 ,  A61K38/00

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERNX4AAX7EIL X11LPNLX16X17X18QX20 WAFIWX26LX28D. The present disclosure also relates to the use of such a PD-L1 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.

公开(公告)号：US09982022B2

公开(公告)日：2018-05-29

申请号：US14911319

申请日：2014-08-28

Applicant: AFFIBODY AB

Inventor： Erik Nordling ,  Joakim Nilsson ,  Patrik Strömberg

IPC: C07K14/31 ,  C07K14/00 ,  C12Q1/68 ,  G01N33/68 ,  C07K1/04

CPC classification number: C07K14/001 ,  C07K1/047 ,  C07K14/31 ,  C07K2319/00 ,  C12Q1/6874 ,  G01N33/6845

Abstract: The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

公开(公告)号：US20180057551A1

公开(公告)日：2018-03-01

申请号：US15548208

申请日：2016-02-22

Applicant: AFFIBODY AB

Inventor： Stefan Ståhl ,  John Löfblom ,  Hanna Lindberg ,  Torleif Härd

IPC: C07K14/47

CPC classification number: C07K14/4711 ,  A61K38/00 ,  C07K2317/92

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid β (Aβ) peptides (in the following referred to as Aβ), comprising the amino acid sequence EX2X3YX5X6NLX9AX11QLCAX16IX18X19X20 ED. The present disclosure also relates to the use of such Aβ peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

公开(公告)号：US09873729B2

公开(公告)日：2018-01-23

申请号：US14776319

申请日：2014-03-17

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Elin Gunneriusson ,  Malin Lindborg ,  Lars Abrahmsen ,  John Löblom ,  Torbjörn Gräslund ,  Johan Seijsing

IPC: C07K14/745 ,  C07K14/735 ,  C07K14/74 ,  C07K14/31 ,  C07K14/435 ,  A61K38/00

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.

公开(公告)号：US09745340B2

公开(公告)日：2017-08-29

申请号：US14436150

申请日：2013-10-25

Applicant: AFFIBODY AB

Inventor： Per Jonasson ,  Pär Eklund

IPC: C07K1/22 ,  C07K14/00 ,  C07K1/14 ,  C07K1/16 ,  C07K14/315 ,  C07K14/31

CPC classification number: C07K1/22 ,  C07K14/00 ,  C07K14/31 ,  C07K14/315 ,  C07K2319/70

Abstract: The disclosure provides a method of separation of at least one ABD-containing molecule present in a liquid from other constituents in the liquid, comprising a step of affinity separation, in which step is used, as affinity ligand, an ABD binding polypeptide comprising an ABD binding motif BM, which motif consists of an amino acid sequence selected from (SEQ ID NO: 166) EX2X3X4AX6X7EIX10X11LPNLX16X17X18QX20X21AFIX25X26LX28D and amino acid sequences with at least 89% identity thereto.

公开(公告)号：US20160311863A1

公开(公告)日：2016-10-27

申请号：US15104070

申请日：2014-12-19

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Fredrik Frejd ,  Joel Lindgren ,  Amelie Eriksson Karlström

IPC: C07K14/315

CPC classification number: C07K14/315 ,  A61K38/00 ,  C07K14/76

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to proteolytic cleavage and therapeutic use thereof. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence (SEQ ID NO. 1782) GXASDX5YKX8X9I X11X12AX14TVEGVX20 ALX23X24X25ILX28X29XB.