公开(公告)号：US20210205352A1

公开(公告)日：2021-07-08

申请号：US17208176

申请日：2021-03-22

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Charles V. Rice

IPC: A61K31/785 ,  A61K31/546 ,  A61K31/545 ,  A61P31/04 ,  A61K31/43

Abstract: The present disclosure describes compositions comprising β-lactam antibiotics and branched polyethylenimines (BPEI), having efficacy against various Gram-positive bacteria, for example Gram-positive bacteria having resistance against β-lactam antibiotics. The compositions result in the resensitization of such resistant bacterial strains to traditional antibiotic therapies such as cephem β-lactam antibiotics.

公开(公告)号：US20210198318A1

公开(公告)日：2021-07-01

申请号：US17192152

申请日：2021-03-04

Applicant: The Board of Regents of the University of Oklahoma

Inventor： David C. KEM ,  Xichun YU ,  Hongliang LI ,  LaTasha B. CRAIG

IPC: C07K7/06 ,  A61P35/00 ,  A61P5/02 ,  C07K7/08 ,  C07K14/71 ,  A61P15/08 ,  C07K5/10

Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.

公开(公告)号：US20210189012A1

公开(公告)日：2021-06-24

申请号：US16838798

申请日：2020-04-02

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Chuanbin Mao ,  Lin Wang ,  Penghe Qiu

IPC: C07K17/14 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39

Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.

公开(公告)号：US20210163572A1

公开(公告)日：2021-06-03

申请号：US16931304

申请日：2020-07-16

Applicant: The Board of Regents of the University of Oklahoma

Inventor： William H. Hildebrand ,  Steven Cate

IPC: C07K14/74 ,  A61M1/30 ,  A61M1/34 ,  C07K16/28 ,  C07K16/06 ,  G01N33/68

Abstract: The production of soluble HLA class II molecules, as well as methods of using the soluble HLA class II molecules so produced, are described herein.

公开(公告)号：US20210115426A1

公开(公告)日：2021-04-22

申请号：US17115321

申请日：2020-12-08

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Anne Kasus-Jacobi ,  Heloise Anne Pereira ,  Amanda J. Stock

IPC: C12N9/64 ,  A61P25/28 ,  C07K14/47 ,  C12N9/96 ,  A61K38/48

Abstract: Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid β peptide into oligomers and/or fibrils, and/or disaggregating amyloid β plaques, and methods of use of the peptide compounds in treatments of, for example, Alzheimer's disease, neuroinflammation, and cerebral amyloid angiopathy.

公开(公告)号：US20210115329A1

公开(公告)日：2021-04-22

申请号：US17063438

申请日：2020-10-05

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Bayram Saparov ,  Tielyr D. Creason ,  Rachel M. Roccanova ,  Aymen Yangui

IPC: C09K11/61 ,  C01G3/00 ,  G07D7/00 ,  G01N21/64 ,  H01L33/50

Abstract: High photoluminescence, high stability, inorganic perovskite compounds comprising an alkali metal selected from potassium (K), rubidium (Rb), and cesium (Cs); copper (Cu); and at least one halogen selected from chlorine (Cl), bromine (Br), and iodine (I). The perovskites may be free of lead (Pb). The inorganic perovskite compound may be used in an optoelectronic device. The optoelectronic device optionally contains a phosphor such as a blue-emitting phosphor. The inorganic perovskite compound may be used as an anti-counterfeiting nanotaggant applied on or within an object that susceptible to counterfeiting to enable confirmation of an authentic object.

公开(公告)号：US10975124B2

公开(公告)日：2021-04-13

申请号：US16274944

申请日：2019-02-13

Applicant: The Board of Regents of the University of Oklahoma

Inventor： David Charles Kem ,  Xichun Yu ,  Hongliang Li ,  LaTasha B. Craig

IPC: C07K7/06 ,  C07K5/10 ,  A61P35/00 ,  A61P5/02 ,  C07K7/08 ,  C07K14/71 ,  A61P15/08 ,  A61K38/00

Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.

公开(公告)号：US20210031885A1

公开(公告)日：2021-02-04

申请号：US16975354

申请日：2019-04-12

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Hernan A. Suarez Montalvo ,  Yih-Ru Huang ,  Yan Zhang

IPC: B63B49/00 ,  B60L8/00

Abstract: A USV comprises a buoyant hull structure; an MCU coupled to the buoyant hull structure; a VHF radio coupled to the buoyant hull structure; a satellite radio coupled to the buoyant hull structure; a GPS coupled to the buoyant hull structure; a plurality of weather sensors coupled to the buoyant hull structure; a navigation and propulsion controller coupled to the buoyant hull structure; at least one thruster coupled to the buoyant hull structure and configured to provide propulsion; a battery coupled to the buoyant hull structure; a charge controller coupled to the buoyant hull structure; and a solar panel coupled to the buoyant hull structure and configured to charge the battery.

公开(公告)号：US10899822B2

公开(公告)日：2021-01-26

申请号：US16697589

申请日：2019-11-27

Applicant: The Board of Regents of the University of Oklahoma

Inventor： David C. Kem

IPC: C07K14/72 ,  A61K39/00 ,  A61K38/08 ,  A61K38/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  C07K7/06

Abstract: Compositions are disclosed that include D-amino acid peptides and that are capable of specifically binding to at least one autoantibody against a G-protein coupled receptor. The autoantibody is produced in a patient having or being predisposed to a disease, condition, or disorder, and the autoantibody is capable of binding to a specific epitope of the G-protein coupled receptor. Methods of production and use of said compositions are also disclosed.

公开(公告)号：US20200315734A1

公开(公告)日：2020-10-08

申请号：US16840254

申请日：2020-04-03

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Christian El Amm

IPC: A61B90/00 ,  G02B27/01 ,  G06T19/00 ,  G06T7/38 ,  G06N20/00 ,  A61B34/20 ,  A61B34/10

Abstract: A method for using a surgical enhanced visualization system for enhancing a surgical operation includes the steps of acquiring patient reference data, loading the patient reference data and features into the computer, and acquiring live data from the operating suite during the surgical operation, where the live data includes a live three dimensional model of the patient. The method continues with the steps of registering the patient reference data and live data and displaying in real time an overlay of selected registered patient reference data onto the patient through the headset worn by the surgeon. The surgical enhanced visualization system may include a computer adapted to store reference data, a sensor module inside the surgical suite that is configured to record live data during the surgical procedure, and an augmented reality headset configured to display both live data and reference data to the surgeon during the surgical procedure.