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公开(公告)号：US20110144411A1
公开(公告)日：2011-06-16
申请号：US12809197
申请日：2008-12-19
CPC分类号： A61M37/00 , A61K9/5094 , A61N2/002 , A61N2/06
摘要： Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.
摘要翻译： 公开了向选定组织提供治疗剂磁力增强递送的系统和方法。 系统和方法涉及使用载体装置和释放装置以及两个不同的磁场以将磁性颗粒移动到选定的组织中。 磁性颗粒（和任何相关联的治疗剂）进入组织的移动可以通过磁性吸引力以及磁性排斥力来辅助。
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公开(公告)号：US07723049B2
公开(公告)日：2010-05-25
申请号：US12389983
申请日：2009-02-20
IPC分类号： G01N33/53
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译： 描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。
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43.发明授权Asynchronus communication system for remote monitoring of objects or an environment 有权异步通信系统用于远程监控对象或环境公开(公告)号：US07643536B2
公开(公告)日：2010-01-05
申请号：US10915576
申请日：2004-08-10
申请人： Timothy Michael Schaefer , Jonathan Darrel Coker , Rick Allen Philpott , Edward Brian Welch , David R. Holmes, III
发明人： Timothy Michael Schaefer , Jonathan Darrel Coker , Rick Allen Philpott , Edward Brian Welch , David R. Holmes, III
IPC分类号： H04B1/00
摘要： A system provides for remote monitoring using asynchronous code division multiple access (CDMA) communication techniques between a base station and one or more transponders. Each transponder is attached or otherwise associated with an object or an environment to be monitored. Upon receipt of an interrogation signal, a transponder generates and transmits a coded transponder signal containing the monitored data. The coded transponder signal is generated using a spreading code. Each transponder is associated with a unique, mutually exclusive set of spreading codes. Each spreading code is based on a unique transponder address and the monitored data to be sent. A detector asynchronously monitors received signals for any of the available spreading codes. Once the detector detects a particular spreading code, the base station can identify the source transponder and extract the monitored data.
摘要翻译： 一种系统提供了在基站和一个或多个转发器之间使用异步码分多址（CDMA）通信技术的远程监控。 每个应答器被连接或以其他方式与要监视的对象或环境相关联。 在接收到询问信号时，应答器产生并发送包含监视数据的编码的应答器信号。 使用扩展码产生编码的应答器信号。 每个转发器与唯一的，相互排斥的扩展码组相关联。 每个扩展码基于唯一的应答器地址和要发送的监视数据。 检测器异步监视任何可用扩展码的接收信号。 一旦检测器检测到特定的扩展码，基站可以识别源应答器并提取监视的数据。
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公开(公告)号：US20090210050A1
公开(公告)日：2009-08-20
申请号：US12429803
申请日：2009-04-24
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译： 提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。 表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长 细胞以有组织的模式。 或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。 本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。
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公开(公告)号：US20090197342A1
公开(公告)日：2009-08-06
申请号：US12389983
申请日：2009-02-20
IPC分类号： G01N33/48
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译： 描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。
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公开(公告)号：US06913762B2
公开(公告)日：2005-07-05
申请号：US09843295
申请日：2001-04-25
CPC分类号： A61F2/90 , A61F2250/0067 , A61L31/14 , B33Y70/00 , B33Y80/00
摘要： Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
摘要翻译： 描述了包括无纺织框架的植入式医疗装置，以及使用这种装置将治疗化合物递送至患者的方法。
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公开(公告)号：US06699675B2
公开(公告)日：2004-03-02
申请号：US10210339
申请日：2002-07-31
IPC分类号： G01N3353
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译： 描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。
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公开(公告)号：US06638258B2
公开(公告)日：2003-10-28
申请号：US10003665
申请日：2001-10-23
IPC分类号： A61M500
CPC分类号： A61M39/24 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/87571 , Y10T137/87652 , Y10T137/87684 , Y10T137/88054
摘要： An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.
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公开(公告)号：US06241710B1
公开(公告)日：2001-06-05
申请号：US09468688
申请日：1999-12-20
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。
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公开(公告)号：US6117102A
公开(公告)日：2000-09-12
申请号：US159007
申请日：1998-09-23
CPC分类号： A61M39/225
摘要： An apparatus for flushing a vascular catheter. Inlet and outlet passages extending from inlet and outlet ports, respectively, are selectably in communication with one another via a manually operable member cooperating with a sealing member and biased toward a closed position. Mechanisms for continuously and periodically flushing the catheter are incorporated.
摘要翻译： 一种用于冲洗血管导管的装置。 从入口和出口分别延伸的入口和出口通道可选地通过与密封构件配合并被朝向关闭位置偏压的可手动操作的构件彼此连通。 引入连续定期冲洗导管的机制。
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