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    Apparatus with weeping tip and method of use
    7.
    发明授权
    Apparatus with weeping tip and method of use 有权
    具有啜饮尖端和使用方法的设备

    公开(公告)号：US07252654B2

    公开(公告)日：2007-08-07

    申请号：US11218700

    申请日：2005-09-02

    申请人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61M5/32 ,  A61M25/00

    CPC分类号： A61M5/3286 ,  A61M5/3291 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

    摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

    Implantable device for promoting repair of a body lumen
    8.
    发明授权
    Implantable device for promoting repair of a body lumen 失效
    用于促进体腔修复的植入式装置

    公开(公告)号：US07235096B1

    公开(公告)日：2007-06-26

    申请号：US09382275

    申请日：1999-08-25

    申请人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61F2/06

    CPC分类号： A61F2/82 ,  A61B5/0031 ,  A61B5/028 ,  A61B5/6862 ,  A61B5/6876 ,  A61F2/0077 ,  A61F2/91 ,  A61L31/14

    摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

    摘要翻译： 提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。 表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长 细胞以有组织的模式。 或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。 本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

    Catheter for drug injection in cardiovascular system
    9.
    发明授权
    Catheter for drug injection in cardiovascular system 失效
    心血管系统药物注射导管

    公开(公告)号：US06605061B2

    公开(公告)日：2003-08-12

    申请号：US09880575

    申请日：2001-06-13

    申请人： Robert A. VanTassel ,  Robert S. Schwartz ,  David R. Holmes

    发明人： Robert A. VanTassel ,  Robert S. Schwartz ,  David R. Holmes

    IPC分类号： A61M5178

    CPC分类号： A61M25/0068 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M25/008 ,  A61M25/0084 ,  A61M2025/009

    摘要： A catheter for injecting medicants into the endocardium, myocardium or other portions of the cardiovascular system is presented where the catheter has apertures therein for ejection and retraction of a needle. The catheter is designed for the apertures in the catheter to press against the tissue to be injected in the heart while the heart is beating. A needle for inserting a prescribed dose of a medicant is ejected through the aperture and a plunger, pump, or diaphragm is moved to deliver a dose of the medicant to tissue adjacent the aperture. By use of the catheter gene therapy, wherein a small does of a gene are injected into the endocardium of the right or left ventricle, can be used to grow new blood vessels in the injected area of a damaged heart. The apertures in the catheter can be spaced at a prescribed distance for the dosage of medicant to form a precise pattern of injections in the area to be treated. The catheters may be used for any treatments of a human or animal patient where injections are required in the heart, veins or arteries of the cardiovascular system.

    摘要翻译： 提供用于将药剂注射到心内膜，心肌或心血管系统的其它部分的导管，其中导管在其中具有孔，用于针的弹出和缩回。 该导管被设计用于在心脏跳动时将导管中的孔压在组织上以被注射到心脏中。 用于插入规定剂量的药剂的针通过孔排出，移动柱塞，泵或隔膜以将剂量的药剂递送到邻近孔的组织。 通过使用其中将小的基因注入右心室或左心室的导管基因治疗可用于在损伤的心脏的注射区域中生长新的血管。 导管中的孔可以间隔规定的距离，用于药物的剂量以在待治疗的区域中形成精确的注射模式。 导管可用于需要在心血管系统的心脏，静脉或动脉中注射的人或动物患者的任何治疗。