公开(公告)号：US20220084203A1

公开(公告)日：2022-03-17

申请号：US17537396

申请日：2021-11-29

申请人： Delphinus Medical Technologies, Inc.

发明人： Olivier Roy ,  Mark Forchette ,  Bruno Dacquay

IPC分类号： G06T7/00 ,  G06V10/84

摘要： Described herein are systems, and methods for aiding a user to classify a volume of tissue. A system as described herein may comprise: a plurality of parameters associated with image characteristics related to one or more images of a volume of tissue; a plurality of probabilities each associated with a potential classification of a region of the volume of tissue and each related to one or more parameters of the plurality of parameters, wherein the plurality of probabilities are assumed to be independent of one another; and a graphical display visible to a user, the display comprising a graphical representation of a subset of relevant parameters of the plurality of parameters, wherein the graphical representation informs a classification of the region of the volume of tissue, and wherein a probability of the classification is represented visually.

公开(公告)号：US11071520B2

公开(公告)日：2021-07-27

申请号：US15909661

申请日：2018-03-01

申请人： Delphinus Medical Technologies, Inc.

发明人： Gursharan Singh Sandhu ,  Nebojsa Duric ,  Cuiping Li ,  Olivier Roy ,  Erik West

IPC分类号： A61B8/13 ,  A61B8/00 ,  G06T11/00 ,  A61B8/15 ,  A61B8/08 ,  G06T11/40

摘要： This application presents a system and related methods that analyze a volume of tissue using ultrasound waveform tomography imaging. By using frequency-domain waveform tomography techniques and a gradient descent algorithm, the system can reconstruct the sound speed distributions of a volume of tissue, such as breast tissue, of varying densities with different types of lesions. By allowing sound speed to have an imaginary component that characterizes sound attenuation, the system can classify the different types of lesions with a fine granularity.

公开(公告)号：US10285667B2

公开(公告)日：2019-05-14

申请号：US14819091

申请日：2015-08-05

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Peter Littrup ,  Cuiping Li

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/14 ,  A61B8/15 ,  G06T5/00

摘要： A method and system for generating an enhanced image of a volume of tissue, comprising: emitting acoustic waveforms toward the volume of tissue; detecting acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating a reflection rendering of a region of the volume of tissue; generating at least one of a sound speed map and an attenuation map of the region of the volume of tissue; generating a transfer map derived from a set of sound speed parameter values of the sound speed map and/or a set of acoustic attenuation parameter values of the acoustic attenuation map, the set of sound speed parameter values and the set of acoustic attenuation parameters associated with the set of elements of the region of the volume of tissue; and rendering an enhanced image of the volume of tissue, derived from processing of the reflection rendering with the transfer map.

公开(公告)号：US10278672B2

公开(公告)日：2019-05-07

申请号：US14835349

申请日：2015-08-25

申请人： Delphinus Medical Technologies, Inc.

发明人： Peter John Littrup ,  Nebojsa Duric

IPC分类号： A61B8/08 ,  G06T7/00 ,  A61B8/00 ,  A61B5/00

摘要： A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.

公开(公告)号：US20190117194A1

公开(公告)日：2019-04-25

申请号：US16182715

申请日：2018-11-07

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Peter Littrup ,  Cuiping Li ,  Olivier Roy ,  Steven Schmidt

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B8/15

摘要： A method and system for analyzing stiffness in a volume of tissue, the method including: emitting acoustic waveforms toward the volume of tissue with an array of ultrasound transmitters; detecting, with an array of ultrasound receivers, a set of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating, from the set of acoustic signals, a sound speed map and an acoustic attenuation map of a region of the volume of tissue, generating a stiffness map derived from combination of a set of sound speed parameter values of the sound speed map and a corresponding set of acoustic attenuation parameter values of the acoustic attenuation map, the stiffness map representing the distribution of the stiffness parameter across the region; and at a display in communication with the computer processor, rendering a stiffness image of the volume of tissue, based upon the stiffness map.

公开(公告)号：US10076304B2

公开(公告)日：2018-09-18

申请号：US14811316

申请日：2015-07-28

申请人： Delphinus Medical Technologies, Inc.

发明人： Mike Tesic ,  Marc Orloff ,  Kevin Obrigkeit ,  David Kunz ,  Roman Janer

IPC分类号： A61B8/00 ,  A61B5/01 ,  A61B8/08 ,  A61B8/13 ,  A61B5/00

CPC分类号： A61B8/406 ,  A61B5/0091 ,  A61B5/01 ,  A61B8/0825 ,  A61B8/13 ,  A61B8/4281 ,  A61B8/4461 ,  A61B8/4494

摘要： A system for providing scanning medium for scanning a volume of tissue comprising: an inner chamber that contains the scanning medium; a transducer mounted to the inner chamber and configured to move along a motion path, with the inner chamber, in scanning the volume of tissue; an outer chamber concentrically aligned about the inner chamber to guide the inner chamber along the motion path; a piston module defining a base surface within the inner chamber, the piston module comprising a medium inlet and a medium outlet for adjusting an amount of the scanning medium within the inner chamber; a detection subsystem coupled to the base surface of the piston module; and an actuator comprising a stationary portion mounted to the piston module and a moving portion coupled to the inner chamber and configured to produce motion of the inner chamber along the motion path.

公开(公告)号：US20180125447A1

公开(公告)日：2018-05-10

申请号：US15731000

申请日：2017-10-12

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Peter John Littrup

IPC分类号： A61B8/08 ,  A61B8/00 ,  G06T7/00 ,  A61B8/06

CPC分类号： A61B8/0825 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/085 ,  A61B8/406 ,  A61B8/4494 ,  A61B8/461 ,  A61B8/466 ,  A61B8/469 ,  A61B8/481 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  G06F19/00 ,  G06T7/0014 ,  G06T2207/10136 ,  G06T2207/30068

摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

公开(公告)号：US09814441B2

公开(公告)日：2017-11-14

申请号：US14755618

申请日：2015-06-30

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Peter John Littrup

IPC分类号： A61B8/08 ,  A61B8/00 ,  G06T7/00 ,  A61B8/06

CPC分类号： A61B8/0825 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/085 ,  A61B8/406 ,  A61B8/4494 ,  A61B8/461 ,  A61B8/466 ,  A61B8/469 ,  A61B8/481 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  G06F19/00 ,  G06T7/0014 ,  G06T2207/10136 ,  G06T2207/30068

摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

公开(公告)号：US20140066760A1

公开(公告)日：2014-03-06

申请号：US13711377

申请日：2012-12-11

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Peter John Littrup

IPC分类号： A61B8/08 ,  A61B8/00

CPC分类号： A61B8/0825 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/085 ,  A61B8/406 ,  A61B8/4494 ,  A61B8/461 ,  A61B8/466 ,  A61B8/469 ,  A61B8/481 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  G06F19/00 ,  G06T7/0014 ,  G06T2207/10136 ,  G06T2207/30068

摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

摘要翻译： 一种用于表征患者组织的方法，包括接收从组织和辐射组织的声波之间的相互作用得到的声学数据; 从声学数据产生组织的形态呈现，其中所述渲染代表所述组织的至少一个生物力学性质; 确定渲染中感兴趣区域的预后参数，其中预后参数包含生物力学性质; 并分析预后参数以表征感兴趣的区域。 在一些实施方案中，该方法还包括将造影剂引入组织中; 在引入造影剂之后产生一组增强的组织形态再现; 从增强的形态渲染确定增强的预后参数; 并分析增强预后参数。

公开(公告)号：US20130204136A1

公开(公告)日：2013-08-08

申请号：US13756851

申请日：2013-02-01

申请人： Delphinus Medical Technologies, Inc.

发明人： Nebojsa Duric ,  Olivier Roy ,  Steven Schmidt ,  Cuiping Li ,  Roman Janer ,  Xiaoyang Cheng ,  Jefferey Goll

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/15

CPC分类号： A61B8/4488 ,  A61B8/0825 ,  A61B8/14 ,  A61B8/15 ,  A61B8/406 ,  A61B8/4209 ,  A61B8/4411 ,  A61B8/4461 ,  A61B8/4494 ,  A61B8/461 ,  A61B8/466 ,  A61B8/467 ,  A61B8/483 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/54 ,  G01S7/52036 ,  G01S15/8922 ,  G01S15/8927 ,  G01S15/8993

摘要： A system and method for imaging a volume of tissue comprising: a modular transducer array, configured to substantially surround the volume of tissue, emit acoustic waveforms toward the volume of tissue, and receive acoustic waveforms scattered by the volume of tissue, comprising a first and a second modular transducer subarray configured to couple to one another; a controller configured to control acoustic signals emitted by the first and the second modular transducer subarrays; an electronic subsystem, coupled to the modular transducer array, comprising a multiplexor and beam-forming elements and configured to receive a set of acoustic data from the first and the second modular transducer subarrays; and a processor configured to analyze the set of acoustic data, determine the distribution of at least one acoustomechanical parameter within the volume of tissue, and render an image of the volume of tissue based on the acoustomechanical parameter.

摘要翻译： 一种用于对组织体积进行成像的系统和方法，包括：模块化换能器阵列，被配置为基本上围绕所述组织体积，朝向所述组织体积发射声波形，并且接收由所述组织体积散射的声波，包括第一和 配置为彼此耦合的第二模块化换能器子阵列; 控制器，被配置为控制由第一和第二模块化换能器子阵列发射的声信号; 耦合到所述模块化换能器阵列的电子子系统，包括多路复用器和波束形成元件，并且被配置为从所述第一和第二模块化换能器子阵列接收一组声学数据; 以及处理器，其被配置为分析所述声学数据集合，确定所述组织体积内的至少一个声学参数的分布，以及基于所述声学参数来渲染所述组织体积的图像。