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公开(公告)号：US20240209337A1
公开(公告)日：2024-06-27
申请号：US18599428
申请日：2024-03-08
申请人： Halozyme, Inc.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12018298B2
公开(公告)日：2024-06-25
申请号：US18340482
申请日：2023-06-23
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20230357739A1
公开(公告)日：2023-11-09
申请号：US18068327
申请日：2022-12-19
申请人： Halozyme, Inc.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
CPC分类号： C12N9/2474 , A61K38/28 , A61K38/47 , A61K45/06 , C12Y302/01035
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20230295592A1
公开(公告)日：2023-09-21
申请号：US18064886
申请日：2022-12-12
申请人： HALOZYME, INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
CPC分类号： C12N9/2474 , A61K38/47 , A61K38/28 , A61K45/06 , C12Y302/01035 , A61K9/0019 , A61K47/10 , C12Q1/34 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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45.发明申请公开(公告)号：US20220372151A1
公开(公告)日：2022-11-24
申请号：US17850903
申请日：2022-06-27
申请人： HALOZYME, INC.
IPC分类号： C07K16/28 , A61K38/47 , A61K31/573 , A61K39/395 , A61P35/00 , C12N9/26 , C12N15/00 , A61K47/60
摘要： Provided are methods of treatment of cancers with combinations of and compositions containing a soluble hyaluronidase, such as a polymer-modified soluble hyaluronidase, and an immune checkpoint inhibitor for treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.
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公开(公告)号：US20210277376A1
公开(公告)日：2021-09-09
申请号：US17327586
申请日：2021-05-21
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US11041149B2
公开(公告)日：2021-06-22
申请号：US16824572
申请日：2020-03-19
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , C12N15/09 , A61K38/47 , A61K38/28 , A61K45/06 , A61K9/00 , A61K47/10 , C12Q1/34 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US10898551B2
公开(公告)日：2021-01-26
申请号：US16373562
申请日：2019-04-02
申请人： HALOZYME, INC.
摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.
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公开(公告)号：US20200255814A1
公开(公告)日：2020-08-13
申请号：US16824572
申请日：2020-03-19
申请人： HALOZYME, INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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50.发明授权公开(公告)号：US09969998B2
公开(公告)日：2018-05-15
申请号：US15094908
申请日：2016-04-08
申请人： Halozyme, Inc.
CPC分类号： C12N9/78 , A61K38/00 , A61K38/48 , C12Y305/04004
摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.
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