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公开(公告)号：US20150120206A1
公开(公告)日：2015-04-30
申请号：US14525148
申请日：2014-10-27
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： Eun Su JANG , Si Woo LEE , Hee Jeong JIN , Jong Hyang YOO , Sang Oak DONG
CPC classification number: A61B5/4854 , A61B5/01 , A61B5/024 , A61B5/20 , A61B5/4255 , A61B5/4266 , G16H50/20 , G16H50/30
Abstract: Provided is a constitutional disease pattern determination apparatus including a calculator to calculate a first deficiency and excess index and a first cold and heat condition index of a user based on clinical information on the user, and a determiner to determine, based on a first reference table corresponding to a first constitution, a first constitutional disease pattern corresponding to the first deficiency and excess index and the first cold and heat condition index among a plurality of constitutional disease patterns included in the first reference table, wherein the first constitution is a constitution classified to correspond to the user based on a Sasang constitution.
Abstract translation: 提供了一种构成疾病模式确定装置，其包括：计算器，用于基于用户的临床信息计算用户的第一缺陷和过剩指数以及用户的第一冷热条件指数;以及确定器，用于基于第一参考表 对应于第一构成，第一参照表中包含的多种宪法疾病模式中的与第一缺陷和过剩指数相对应的第一构造疾病模式和第一冷热条件指数，其中第一构成是分类为 对应于基于Sasang宪法的用户。
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公开(公告)号：US20250009832A1
公开(公告)日：2025-01-09
申请号：US18289284
申请日：2022-05-03
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： HWAN SUCK CHUNG , EUN-JI LEE , JANG GI CHOI , JI HYE KIM , YOUNG SOO KIM , TAEIN KIM , WEI LI
IPC: A61K36/739 , A61K45/06 , A61P35/00
Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.
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公开(公告)号：US20240016878A1
公开(公告)日：2024-01-18
申请号：US18038537
申请日：2020-10-27
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： Kwang-Hoon SONG
IPC: A61K36/899 , A61P5/26 , A61K8/9794
CPC classification number: A61K36/899 , A61P5/26 , A61K8/9794 , A61K2236/331 , A61K2236/333
Abstract: A composition for preventing, ameliorating or treating an androgen-dependent disorder includes Phyllostachys pubescens extract as an effective component. It was found that, compared to the extracts of other types of bamboo, the Phyllostachys pubescens extract of the present invention can significantly reduce the expression amount of the SRD5A2 gene which encodes 5α-reductase while hardly showing any cytotoxicity. The composition of the present invention was found to have effects that can reduce the prostate weight, reduce the proliferation of epithelial cells in prostate tissues, and also can reduce the content of testosterone, dihydrotestosterone, PSA, and SRD5A2 in blood serum. Thus, the composition of the present invention can be advantageously used for an androgen-dependent disorder.
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公开(公告)号：US20220409723A1
公开(公告)日：2022-12-29
申请号：US17778368
申请日：2020-11-16
Inventor： Young Hee JIN , Sun Oh KWON , Dong Eon KIM , Jung Sun MIN , Min Seong JANG
Abstract: Provided are a vaccine adjuvant composition including, as an active ingredient, bavachin capable of improving antibody titer and enhancing cellular immunity and humoral immunity when administered together with an antigen, a vaccine preparation including the bavachin and an antigen, a method of promoting an immune response, the method including the step of administering the vaccine adjuvant composition to a subject together with a vaccine composition or before and after administration of the vaccine composition, and a vaccine adjuvant composition for promoting an immune response, the vaccine adjuvant composition including the bavachin. Since the vaccine adjuvant composition of the present invention includes bavachin isolated from an extract of Psoralea corylifolia, of which safety has been secured, it may exhibit safety and may enhance both the humoral and cellular immune responses as well as the titer of antibodies generated by antigens.
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公开(公告)号：US20220323530A1
公开(公告)日：2022-10-13
申请号：US17613664
申请日：2020-04-29
Applicant: Korea Institute of Oriental Medicine
Inventor： Hyun Il HA , Tae Soo KIM , Youn Hwan HWANG , Seon A JANG
IPC: A61K36/532 , A61K31/7048 , A61P19/08
Abstract: The Agastache rugosa extract or the isoagastachoside or crude polysaccharide fraction included in the extract according to the present invention can be prepared based on plants being domestically cultivated, and thus is advantageous in terms of time and cost, and can effectively inhibit the differentiation, growth, and bone resorption functions of osteoclast progenitor cells, thus increasing bone density and the like, and accordingly, can be effectively used for the prevention, amelioration, or treatment of diseases related to bone loss caused by differentiation into osteoclasts or excessive activity of osteoclasts. In addition, the active ingredient, which is a plant-derived natural substance, is safe due to fewer side effects on the human body compared to chemical drugs, and inhibits osteoclast progenitor cells independently of estrogen, and thus can be widely used in osteoporosis occurring due to various causes other than menopause.
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Patent Agency Ranking
公开(公告)号：US11253566B2
公开(公告)日：2022-02-22
申请号：US16755338
申请日：2018-10-15
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： Mi Young Lee , Yu Ri Kim , Bo-Kyung Park , Young Hwa Kim
IPC: A61K36/63 , A23L33/105 , A23L33/00 , A61P25/22 , A61P25/24
Abstract: A method for preventing or treating at least one of depression and anxiety disorder according to an embodiment of the present invention includes administering to a subject in need thereof a composition having an extract of Fraxinus rhynchophylla as an effective ingredient. By having an effect of improving depressive behavior and low physical activity shown in an animal model with induced anxiety and depression, reducing the level of cortisol, increasing the level of serotonin, and also increasing the expression amount of pCERB, BDNF, and mBDNF proteins in hippocampal tissues, the compositions can be advantageously used for developing a functional health food product or a pharmaceutical product for ameliorating or treating the depression and anxiety disorder.
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公开(公告)号：US20210338761A1
公开(公告)日：2021-11-04
申请号：US17284574
申请日：2019-09-26
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： Mi Young LEE , Yu Ri KIM , Young Hwa KIM , Bo-Kyung PARK
IPC: A61K36/63 , A61P25/20 , A23L33/105
Abstract: A method for treating sleep disturbance according to an embodiment of the present disclosure includes an extract of Fraxinus sp. plant as an effective component. As the extract of Fraxinus rhynchophylla of the present invention has an effect of ameliorating sleep disturbance by increasing the mRNA expression level of calretinin, neuropeptide Y, GAD65 and GAD67 in an animal model which has sleep disturbance caused by stress, it can be advantageously used as a raw material of a functional health food or a pharmaceutical product for preventing, ameliorating, or treating sleep disturbance.
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公开(公告)号：US20210105452A1
公开(公告)日：2021-04-08
申请号：US15733139
申请日：2018-12-18
Applicant: Korea Institute of Oriental Medicine
Inventor： Jun Hyeong Do , Young Min Kim , Jun Su Jang
IPC: H04N13/221 , G06T7/579
Abstract: The present invention relates to a three-dimensional face image capturing method and comprises the steps of: capturing a face region of a user in a direction from a right chin to a left forehead; capturing the face region in a direction from a left forehead to a left chin; capturing the face region in a direction from a left chin to a right forehead; and capturing the face region in a direction from a right forehead to a center of face.
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公开(公告)号：US20200245948A1
公开(公告)日：2020-08-06
申请号：US16757101
申请日：2018-09-18
Applicant: Korea Institute of Oriental Medicine
Inventor： Jang Han Bae , Young Ju Jeon , Jong Yeol Kim
Abstract: A method for determining a sharpness index of a pulse wave signal according to an embodiment comprises the steps of: receiving a pulse wave signal; determining a first reference line starting point and a second reference line starting point on the basis of a curvature of the pulse wave signal; determining a first reference line connecting the first reference line starting point and a first reference line ending point by determining the first reference line ending point by applying an intersecting tangent method to the first reference line starting point, and determining a second reference line connecting the second reference line starting point and a second reference line ending point by determining the second reference line ending point by applying the intersecting tangent method to the second reference line starting point; and determining a sharpness index by using a peak point of the pulse wave signal, the first reference line, and the second reference line.
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公开(公告)号：US20200160615A1
公开(公告)日：2020-05-21
申请号：US16605126
申请日：2018-02-08
Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
Inventor： Jun Su Jang , Jun Hyeong Do
IPC: G06T19/20
Abstract: Provided is a face pose correction apparatus for correcting a face pose, using a person-specific frontal model specialized for input three-dimensional (3D) facial data. The face pose correction apparatus may comprise: a generation unit for generating corrected first facial data by performing a 3D rigid transformation of input 3D facial data on the basis of a pre-stored 3D standard facial model; and a correction unit for generating a first subject-specialized frontal model which is a bilateral symmetry model of the first facial data, and correcting the first facial data by performing the 3D rigid transformation of the first facial data on the basis of the generated first subject-specialized frontal model.
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