公开(公告)号：US12270068B2

公开(公告)日：2025-04-08

申请号：US17793926

申请日：2021-01-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Yair Rivenson ,  Hongda Wang ,  Hatice Ceylan Koydemir ,  Yunzhe Qiu

IPC: C12Q1/04 ,  G02B21/26 ,  G02B21/36 ,  G03H1/00 ,  G06V10/10 ,  G06V10/82 ,  G06V20/69 ,  H04N23/56 ,  H04N23/698

Abstract: A system for the detection and classification of live microorganisms in a sample includes a light source and an incubator holding one or more sample-containing growth plates. A translation stage moves the image sensor and/or the growth plate(s) along one or more dimensions to capture time-lapse holographic images of microorganisms. Image processing software executed by a computing device captures time-lapse holographic images of the microorganisms or clusters of microorganisms on the one or more growth plates. The image processing software is configured to detect candidate microorganism colonies in reconstructed, time-lapse holographic images based on differential image analysis. The image processing software includes one or more trained deep neural networks that process the time-lapsed image(s) of candidate microorganism colonies to detect true microorganism colonies and/or output a species associated with each true microorganism colony.

公开(公告)号：US12269925B1

公开(公告)日：2025-04-08

申请号：US18803077

申请日：2024-08-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal

IPC: C08G75/14 ,  C08K5/45 ,  C09J181/04

Abstract: Biocompatible and biodegradable polymers are provided herein as compositions, methods, and systems for making the compositions. These polymers can be adjustably stable and used in medical applications as adhesives and sealants, and in non-medical applications. Radical polymerization protocols, and two-step cationic and radical polymerization protocols, are provided for the creation of stable, polydisulfide polymers, which can be done in aqueous solution and at ambient and in vivo temperatures ranging, for example, from 0° C. to 37° C. The compositions are biocompatible and can be used as fast curing, biocompatible and biodegradable adhesives and sealants suitable for use in the consumer, industrial, military and medical arts, namely as a functional biomaterial, sustainable plastic, surgical superglue, bone adhesive, pressure-sensitive adhesive, structural adhesive, and other relevant sustainable materials with closed-loop recycling.

公开(公告)号：US12269805B2

公开(公告)日：2025-04-08

申请号：US17969519

申请日：2022-10-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michael Holinstat ,  Reheman Adili ,  Andrew White ,  Theodore R. Holman

IPC: C07D249/12 ,  A61P7/02 ,  C07D403/12

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

公开(公告)号：US12267094B2

公开(公告)日：2025-04-01

申请号：US17640691

申请日：2020-09-03

Applicant: The Regents of the University of California

Inventor： James F. Buckwalter ,  Hussam Alshammary

IPC: H04B1/10 ,  H04L5/00 ,  H04L27/00

Abstract: A method for carrier aggregation receives a signal with multiple non-contiguous carrier bands. Frequency converting of the signal to a compressed single intermediate frequency band with a pseudonoise code applied to a local oscillation of each of the multiple non-contiguous carrier bands while maintaining separation of the multiple non-contiguous carrier bands permits reduced complexity digital signal processing to detect spectral power density and demodulate waveforms across multiple channels. A receiver includes a pseudorandom noise generator applying a pseudo noise code to the local oscillator generator to produce a unique set of spectral tones in the output signal that sample-specific channels over the multiple non-contiguous carrier bands.

公开(公告)号：US20250099496A1

公开(公告)日：2025-03-27

申请号：US18730598

申请日：2023-01-19

Applicant: The Regents of the University of California ,  University of South Alabama

Inventor： Ru Bryan ,  Marie Migaud

IPC: A61K31/706 ,  A61K31/519 ,  A61K31/7068 ,  A61P19/02 ,  A61P19/06

Abstract: Compositions and methods of treatment for osteoarthritis and cartilage damage in a subject comprising administering to a subject in need thereof an effective amount of a dihydronicotinamide riboside (NRH). Compositions and methods of treatment for osteoarthritis, cartilage damage, gout or aging-associated diseases in a subject comprising administering to a subject in need thereof an effective amount of NRH and/or nicotinamide riboside (NR) and administering to the subject an effective amount of a purine nucleoside phosphorylase (PNP) inhibitor.

公开(公告)号：US20250099412A1

公开(公告)日：2025-03-27

申请号：US18730028

申请日：2023-01-18

Applicant: The Regents of the University of California

Inventor： Geert W. Schmid-Schoenbein ,  Frank A. DeLano

IPC: A61K31/195 ,  A61P1/00 ,  A61P9/00 ,  A61P25/00

Abstract: Provided herein are methods of reversing accumulation of a serine protease. reversing cellular damage. and/or preserving extracellular matrix in an organ of a subject comprising selecting a subject at risk of damage to the organ, and administering a therapeutically effective amount of a serine protease inhibitor. The serine protease inhibitor may be an orally administered competitive inhibitor.

公开(公告)号：US12260549B2

公开(公告)日：2025-03-25

申请号：US17672613

申请日：2022-02-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Albert Hsiao ,  Evan Masutani ,  Sophie You

IPC: G06T7/00 ,  G06N3/08 ,  G06T7/20 ,  G06V10/82

Abstract: A method and system for automated correction of phase error in MRI-based flow evaluation employs a computer processor programmed to execute a trained convolutional neural network (CNN) to receive and process image data comprising flow velocity data in three directions and magnitude data collected from a region of interest over a scan period from magnetic resonance imaging instrumentation. The image data is processed using the trained CNN to generate three output channels with pixelwise inferred corrections for the flow velocity data which are further smoothed using a regression algorithm. The smoothed corrections are added to the original image data to generate corrected flow data, which may be used for flow visualization and quantization.

公开(公告)号：US12258575B2

公开(公告)日：2025-03-25

申请号：US17749017

申请日：2022-05-19

Applicant: The Regents of the University of California

Inventor： Jennifer A. Doudna ,  Jillian F. Banfield ,  David Burstein ,  Lucas Benjamin Harrington

IPC: C12N9/22 ,  A61K38/46 ,  C12N15/113 ,  C12N15/90

Abstract: The present disclosure provides CasY proteins, nucleic acids encoding the CasY proteins, and modified host cells comprising the CasY proteins and/or nucleic acids encoding same. CasY proteins are useful in a variety of applications, which are provided. The present disclosure provides CasY guide RNAs that bind to and provide sequence specificity to the CasY proteins, nucleic acids encoding the CasY guide RNAs, and modified host cells comprising the CasY guide RNAs and/or nucleic acids encoding same. CasY guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides methods of identifying a CRISPR RNA-guided endonuclease.

公开(公告)号：US12257456B2

公开(公告)日：2025-03-25

申请号：US17779899

申请日：2020-11-25

Applicant: The Regents of the University of California

Inventor： Ke Sheng ,  Qihui Lyu

IPC: A61N5/10

Abstract: A system and method for delivering radiation therapy to a patient includes generating a radiation therapy plan and adjusting a shape of at least one of a plurality of multi-leaf collimators (MLCs) arranged in an arc about a patient bed to create a respective plurality of desired beam profiles for each of the plurality of MLCs to thereby implement the ultrafast radiation therapy plan delivery. The method further includes control a radiation therapy source to execute the radiation therapy plan by creating the respective plurality of desired beam profiles for each of the plurality of MLCs.

公开(公告)号：US12257326B2

公开(公告)日：2025-03-25

申请号：US17018314

申请日：2020-09-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Jose Manuel Mejia Oneto ,  Maksim Royzen

IPC: A61K51/06 ,  A61K31/43 ,  A61K31/7076 ,  A61K38/12 ,  A61K38/14 ,  A61K47/54 ,  A61K47/61 ,  A61K47/66 ,  A61K47/69 ,  A61K49/00 ,  A61K51/04 ,  A61K51/12 ,  C07D257/08 ,  C07D311/82 ,  C07D499/74 ,  C07H7/02 ,  C07H15/24 ,  C07H19/167 ,  C07H19/213

Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.