公开(公告)号：US5338490A

公开(公告)日：1994-08-16

申请号：US114971

申请日：1993-08-31

Applicant: Timothy M. Dietz ,  Robert A. Asmus ,  Rosa Uy

Inventor： Timothy M. Dietz ,  Robert A. Asmus ,  Rosa Uy

IPC: A61B5/0408 ,  A61L24/00 ,  A61F13/02 ,  C08J3/00 ,  C08K5/15 ,  C08L5/00

CPC classification number: A61B5/04087 ,  A61L24/0094

Abstract: A two-phase composite of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composite and methods of preparing the composite and the electrode are disclosed. The continuous phase is a hydrophilic, solid state pressure-sensitive adhesive composition ionically-conductive regardless of an amount of water present in the composition. The discontinuous phase are domains of a hydrophobic pressure-sensitive adhesive which enhances adhesion of the composite to mammalian skin while maintaining acceptable alternating current impedance of the composite.

Abstract translation: 公开了一种离子导电压敏粘合剂的两相复合材料，使用复合材料的生物医学电极以及制备复合材料和电极的方法。 连续相是离子导电的亲水性固态压敏粘合剂组合物，而不管组合物中存在的水量如何。 不连续相是疏水性压敏粘合剂的结构域，其增强了复合材料对哺乳动物皮肤的粘附，同时保持了复合材料的可接受的交流阻抗。

公开(公告)号：US4931282A

公开(公告)日：1990-06-05

申请号：US125377

申请日：1987-11-25

Applicant: Robert A. Asmus ,  Daniel C. Duan

Inventor： Robert A. Asmus ,  Daniel C. Duan

IPC: A61L26/00 ,  A61L15/58 ,  A61L24/00 ,  A61L24/06

CPC classification number: A61L15/58 ,  A61L24/0015 ,  A61L24/06 ,  A61L2300/106 ,  A61L2300/406 ,  Y10S526/931

Abstract: A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.

公开(公告)号：US20140235712A1

公开(公告)日：2014-08-21

申请号：US14347265

申请日：2012-09-28

Applicant: Robert A. ASMUS ,  Hae-Seung LEE ,  John D. DELL ,  Deena M. CONRAD-VLASAK ,  3M INNOVATIVE PROPERTIES COMPANY

Inventor： Robert A. Asmus ,  Hae-Seung Lee ,  John D. Dell ,  Deena M. Conrad-Vlasak

IPC: A61K9/70 ,  A61K31/275

CPC classification number: A61K9/7007 ,  A61K31/275 ,  A61L24/043 ,  A61L24/06 ,  A61L26/0014 ,  C09D109/06 ,  C09D153/02 ,  F04C2270/041 ,  C08L35/04

Abstract: The disclosed conformable coating provides a highly durable and resilient film useful for protecting and repairing surfaces such as skin and mucous membranes. A conformable coating composition comprises an elastomer, a volatile liquid, wherein the volatile liquid is at least 40% wt. of the total composition and the composition has a viscosity less than 1,000 cps. Disclosed is a conformable film that comprises an elastomer on a substrate, wherein the coating weight is from 1 to 30 mg/in2, and wherein the film has less than 75% failure at 100% elongation.

Abstract translation: 所公开的贴合涂层提供了用于保护和修复表面如皮肤和粘膜的高度耐用和有弹性的膜。 合适的涂料组合物包含弹性体，挥发性液体，其中挥发性液体为至少40重量％。 的总组合物和组合物的粘度小于1,000cps。 公开了一种在基材上包含弹性体的适形膜，其中涂层重量为1至30mg / in2，并且其中该膜在100％伸长率下具有小于75％的失效。

公开(公告)号：US20130273593A1

公开(公告)日：2013-10-17

申请号：US13995524

申请日：2011-12-20

Applicant: William E. Foltz ,  Francois Ahimou ,  G. Marco Bommarito ,  Robert A. Asmus ,  Louis C. Haddad ,  Tushar A. Kshirsagar

Inventor： William E. Foltz ,  Francois Ahimou ,  G. Marco Bommarito ,  Robert A. Asmus ,  Louis C. Haddad ,  Tushar A. Kshirsagar

IPC: C12Q1/25

CPC classification number: C12Q1/22 ,  C12Q1/25 ,  G01N21/78 ,  G01N31/226 ,  G01N33/573 ,  G01N2021/7786 ,  G01N2458/00

Abstract: Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.

公开(公告)号：US08062649B2

公开(公告)日：2011-11-22

申请号：US10463497

申请日：2003-06-17

Applicant: Robert A. Asmus ,  Matthew T. Scholz

Inventor： Robert A. Asmus ,  Matthew T. Scholz

IPC: A01N25/00 ,  A61K31/74 ,  A61K47/48 ,  A61K31/045

CPC classification number: A01N31/02 ,  A61K31/155 ,  A01N47/44 ,  A01N25/10 ,  A01N2300/00

Abstract: An antimicrobial hydroalcoholic composition comprising hydroalcoholic solvent system comprising a lower alcohol and water in a weight ratio of at least about 50:50; a thickener system comprising at least one cationic or nonionic polymeric thickener that is solid at ambient temperature; and a secondary antimicrobial agent.

Abstract translation: 一种抗微生物水醇组合物，其包含水醇溶剂体系，其包含重量比为至少约50:50的低级醇和水; 包含至少一种在环境温度下为固体的阳离子或非离子聚合增稠剂的增稠剂体系; 和二级抗微生物剂。

公开(公告)号：US06623744B2

公开(公告)日：2003-09-23

申请号：US10075509

申请日：2002-02-14

Applicant: Robert A. Asmus ,  Matthew T. Scholz ,  Jill R. Charpentier

Inventor： Robert A. Asmus ,  Matthew T. Scholz ,  Jill R. Charpentier

IPC: A61K700

CPC classification number: A61Q19/00 ,  A61K8/31 ,  A61K8/34 ,  A61K8/342 ,  A61K8/39 ,  A61K8/86 ,  A61K8/894 ,  A61K31/045 ,  A61Q17/005 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941

Abstract: A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

公开(公告)号：US06582711B1

公开(公告)日：2003-06-24

申请号：US08781095

申请日：1997-01-09

Applicant: Robert A. Asmus ,  Matthew T. Scholz

Inventor： Robert A. Asmus ,  Matthew T. Scholz

IPC: A01N2502

CPC classification number: A01N31/02 ,  A61K31/155 ,  A01N47/44 ,  A01N25/10 ,  A01N2300/00

Abstract: An antimicrobial hydroalcoholic composition comprising hydroalcoholic solvent system comprising a lower alcohol and water in a weight ratio of at least about 50:50; a thickener system comprising at least one cationic or nonionic polymeric thickener that is solid at ambient temperature; and a secondary antimicrobial agent.

Abstract translation: 一种抗微生物水醇组合物，其包含水醇溶剂体系，其包含重量比为至少约50:50的低级醇和水; 包含至少一种在环境温度下为固体的阳离子或非离子聚合增稠剂的增稠剂体系; 和二级抗微生物剂。

公开(公告)号：US5389376A

公开(公告)日：1995-02-14

申请号：US139516

申请日：1993-10-15

Applicant: Daniel C. Duan ,  Robert A. Asmus ,  Timothy M. Dietz ,  Rosa Uy ,  Olester Benson, Jr.

Inventor： Daniel C. Duan ,  Robert A. Asmus ,  Timothy M. Dietz ,  Rosa Uy ,  Olester Benson, Jr.

IPC: A61B5/0408 ,  A61K9/70 ,  A61L15/58 ,  A61N1/30 ,  C08F20/26 ,  C08F20/52 ,  C08F26/10 ,  C08F220/28 ,  C08F220/56 ,  C08F226/10 ,  C09J137/00 ,  C09J139/04 ,  H01R4/04 ,  A61F13/02

CPC classification number: A61K9/703 ,  A61K9/7053 ,  A61L15/58 ,  C09J139/04 ,  H01R4/04 ,  H01R2201/12 ,  Y10S522/912 ,  Y10S526/931

Abstract: A hydrophilic, pressure-sensitive adhesive composition prepared by irradiating solid poly(N-vinyl lactam) with ionizing radiation to crosslink the poly(N-vinyl lactam) and thereafter mixing the radiation-crosslinked poly(N-vinyl lactam) with essentially unirradiated plasticizer in an amount sufficient to form a cohesive, pressure-sensitive adhesive composition. The composition is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The composition is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The composition is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the composition is also disclosed.

Abstract translation: 通过用电离辐射照射固体聚（N-乙烯基内酰胺）以交联聚（N-乙烯基内酰胺），然后将辐射交联的聚（N-乙烯基内酰胺）与基本上未照射的增塑剂混合而制备的亲水性压敏粘合剂组合物 其量足以形成粘合的压敏粘合剂组合物。 该组合物可用作生物医学粘合剂，用于作为生物医学电极的组分传输或接收电信号。 组合物还可用作药物递送装置，以将药物或其它活性成分递送至哺乳动物皮肤或通过哺乳动物皮肤。 组合物还可用作皮肤覆盖物中用于用抗微生物剂保护哺乳动物皮肤或哺乳动物皮肤开口的组分。 还公开了组合物的制备方法。

公开(公告)号：US5369155A

公开(公告)日：1994-11-29

申请号：US86324

申请日：1993-07-01

Applicant: Robert A. Asmus

Inventor： Robert A. Asmus

IPC: A61F13/00 ,  A61L15/58 ,  A61L24/04 ,  C08J3/20 ,  C08K5/05 ,  C08L89/00

CPC classification number: A61L15/585 ,  A61L24/043 ,  A61F2013/0071 ,  A61L2400/14

Abstract: A composite of a gel of swollen hydrocolloid dispersed in a pressure sensitive adhesive matrix is provided. The gel has a natural or synthetically derived hydrocolloid swollen with a non-volatile swelling agent, such that the gel may have a shear modulus of less than 6.2.times.10.sub.6 dynes/cm.sup.2 The gel-adhesive composite has continued skin adhesion whether applied to or existing in dry or moist skin conditions. The gel contributes a high moisture vapor transmission rate to attempt to maintain dry skin conditions while the adhesive maintains skin adhesion. The gel-adhesive composite may be used in a variety of tape, dressing, bandage, drape, or other skin contacting usage and may optionally include antimicrobial agents to treat the skin while adhesion continues.

Abstract translation: 提供分散在压敏粘合剂基质中的溶胀水胶体凝胶的复合物。 凝胶具有天然或合成衍生的水性胶体与非挥发性溶胀剂溶胀，使得凝胶可以具有小于6.2×10 6达因/ cm 2的剪切模量。凝胶粘合剂复合材料具有持续的皮肤粘附性，不管其是否应用于或存在于 干燥或潮湿的皮肤状况。 凝胶具有很高的水汽透过率，试图在粘合剂保持皮肤粘附性的同时保持皮肤干燥状态。 胶粘剂复合材料可以用于各种胶带，敷料，绷带，悬垂或其它皮肤接触用途，并且可以任选地包括抗微生物剂以在粘合继续的同时治疗皮肤。