公开(公告)号：US12097262B2

公开(公告)日：2024-09-24

申请号：US18176335

申请日：2023-02-28

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Kevan Shokat ,  Masanori Okaniwa

IPC分类号： C07D498/18 ,  A61K31/436 ,  A61K31/519 ,  A61K47/55 ,  A61P25/00 ,  A61P35/00 ,  C07D519/00

CPC分类号： A61K47/55 ,  A61K31/436 ,  A61K31/519

摘要： Disclosed herein, inter alia, are compounds and methods of using the same for modulating the activity of mTORC1.

公开(公告)号：US20240314006A1

公开(公告)日：2024-09-19

申请号：US18491558

申请日：2023-10-20

申请人： California Institute of Technology ,  The Regents of the University of California ,  Technische Universität Berlin

发明人： Philipp Walk ,  Babak Hassibi ,  Peter Jung ,  Hamid Jafarkhani

IPC分类号： H04L27/26 ,  H04B1/04 ,  H04B7/0452 ,  H04L7/04 ,  H04L27/12

CPC分类号： H04L27/2602 ,  H04B1/0475 ,  H04B7/0452 ,  H04L7/042 ,  H04L7/048 ,  H04L27/122

摘要： Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

公开(公告)号：US20240312783A1

公开(公告)日：2024-09-19

申请号：US18357297

申请日：2023-07-24

申请人： The Regents of the University of California

发明人： Daniel Staaks

IPC分类号： H01L21/027

CPC分类号： H01L21/027

摘要： This disclosure provides systems, methods, and apparatus related to extreme ultraviolet lithography. In one aspect, a method of fabricating a mask for extreme ultraviolet lithography includes providing a structure, depositing an absorber layer over the reflective layer, and patterning the absorber layer. The structure includes a substrate and a reflective layer disposed over the substrate. The absorber layer comprises A and B. A is chromium (Cr) or vanadium (V). B is silver (Ag), indium (In), cobalt (Co), antimony (Sb), tin (Sn), or tellurium (Te). Patterning the absorber layer includes etching the absorber layer to remove the absorber layer in a first region while leaving the absorber layer in a second region. The etching is performed at a temperature of about −80° C. to 0° C.

公开(公告)号：US20240310344A1

公开(公告)日：2024-09-19

申请号：US18420137

申请日：2024-01-23

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Reginald M. Penner ,  Won-Tae Koo ,  Il-Doo Kim

IPC分类号： G01N33/00 ,  C23C14/58 ,  C25D1/04 ,  C25D3/50 ,  C25D5/02 ,  C25D5/40 ,  C25D5/48 ,  G01N27/12

CPC分类号： G01N33/005 ,  C23C14/5873 ,  C25D1/04 ,  C25D3/50 ,  C25D5/022 ,  C25D5/40 ,  C25D5/48 ,  G01N27/127

摘要： Systems and methods using engineered nanofiltration layers to facilitate acceleration of palladium nanowire hydrogen sensors. The sensors include a metal-organic framework (MOF) assembled on palladium (Pd) nanowires (NWs) for highly selective and ultra-fast H2 molecule detection.

公开(公告)号：US12091393B2

公开(公告)日：2024-09-17

申请号：US17287914

申请日：2019-10-22

申请人： The Regents of the University of California

发明人： Dennis Carson ,  Mary Patricia Corr ,  Howard B. Cottam ,  Tomoko Hayashi ,  Nikunj Shukla

IPC分类号： C07D277/44 ,  A61K39/39 ,  A61K39/00

CPC分类号： C07D277/44 ,  A61K39/39 ,  A61K2039/55511

摘要： Compounds of formulae (I)-(VD):

A1-Q-L1-A2-L2-Z  Formula I

are useful for enhancing or prolonging an immune response, such as, in a vaccine as an adjuvant or a co-adjuvant.

公开(公告)号：US20240304283A1

公开(公告)日：2024-09-12

申请号：US18390753

申请日：2023-12-20

申请人： The Regents of the University of California

发明人： Stephanie I. Fraley ,  Sinead Charpentier ,  Daniel Ortiz Velez ,  Mridu Sinha ,  Benjamin Albert Yang

IPC分类号： G16B40/10 ,  C12Q1/686 ,  G16B25/00 ,  G16B25/20 ,  G16B30/00

CPC分类号： G16B40/10 ,  C12Q1/686 ,  G16B25/00 ,  G16B25/20 ,  G16B30/00

摘要： Methods are provided for nucleic acid analysis via a platform which incorporates a digital sample partitioning platform such as a microfluidic chip or digital droplet platform and instrumentation to accomplish universal amplification, High Resolution Melting (TIRM), and machine learning within reactions simultaneously.

公开(公告)号：US20240302598A1

公开(公告)日：2024-09-12

申请号：US18665950

申请日：2024-05-16

申请人： The Regents of the University of California

发明人： Tae Joon SEOK ,  Ming Chiang A WU

IPC分类号： G02B6/35 ,  G02B6/12 ,  G02B6/293

CPC分类号： G02B6/3546 ,  G02B6/3508 ,  G02B6/12007 ,  G02B2006/12145 ,  G02B6/29344

摘要： A large-scale silicon-photonics-based optical switching system that occupies an area larger than the maximum area of a standard step-and-repeat lithography reticle is disclosed. The system includes a plurality of identical switch blocks, each of is formed in a different reticle field that no larger than the maximum reticle size. Bus waveguides of laterally adjacent switch blocks are stitched together at lateral interfaces that include a second arrangement of waveguide ports that is common to all lateral interfaces. Bus waveguides of vertically adjacent switch blocks are stitched together at vertical interfaces that include a first arrangement of waveguide ports that is common to all vertical interfaces. In some embodiments, the lateral and vertical interfaces include waveguide ports having waveguide coupling regions that are configured to mitigate optical loss due to stitching error.

公开(公告)号：US20240301403A1

公开(公告)日：2024-09-12

申请号：US18263366

申请日：2022-01-28

申请人： The Regents of the University of California

发明人： Daniel B. GOODMAN ,  Camillia S. AZIMI ,  Kole T. ROYBAL ,  Jeffrey A. BLUESTONE ,  Alexander MARSON

IPC分类号： C12N15/10 ,  C12N15/86

CPC分类号： C12N15/1093 ,  C12N15/86 ,  C12N2750/14143

摘要： This disclosure generally relates to high-throughput and modular methods and compositions for barcode-trackable cellular receptor design, manufacture, and measurement.

公开(公告)号：US20240297357A1

公开(公告)日：2024-09-05

申请号：US18634704

申请日：2024-04-12

申请人： The Regents of the University of California

发明人： Zheng CHEN ,  Panpan XU

IPC分类号： H01M10/54 ,  C22B7/00 ,  C22B26/12 ,  H01M4/02 ,  H01M4/04 ,  H01M4/58

CPC分类号： H01M10/54 ,  C22B7/006 ,  C22B26/12 ,  H01M4/0471 ,  H01M4/049 ,  H01M4/5825 ,  H01M2004/028

摘要： A method for regeneration of spent cathode material of lithium-ion batteries involves lithiating the cathode material in a relithiation solution including a reducing agent at a temperature in the range of 60° C. to 180° C. for a sufficient time to heal composition defects in the cathode material. The lithiated material is then sintered to completely recover the properties. The relithiation solution may be a Li-ion source combined with nature-based organic reducing agent such as citric acid, ascorbic acid, tartaric acid, or similar.

公开(公告)号：US20240294601A1

公开(公告)日：2024-09-05

申请号：US18482755

申请日：2023-10-06

申请人： The Regents of the University of California

发明人： Nikolaos Sgourakis

IPC分类号： C07K14/74 ,  B01J19/00 ,  C40B30/04

CPC分类号： C07K14/70539 ,  B01J19/0046 ,  C40B30/04 ,  B01J2219/00725

摘要： Compositions that include stable peptide deficient MHC class I/chaperone complexes and methods of making and using such complexes are provided. In particular embodiments, such peptide deficient MHC class I/chaperone complexes are used to form peptide MHC class I (pMHC-I) multimers useful for high throughput applications, such as, for the detection of antigen specific T cells and characterization of T cell profiles in subjects.