公开(公告)号：US12247679B2

公开(公告)日：2025-03-11

申请号：US17736914

申请日：2022-05-04

Applicant: The United States of America, as represented by the Secretary of the Navy

Inventor： Raymond Mark Gamache ,  Christopher Marc LeTorre Phifer

IPC: F16L11/12 ,  F16L11/20

Abstract: A self-sealing hose includes an inner rubber layer comprising a first rubber material; and an outer rubber layer comprising a second rubber material. The second rubber material has an ultimate strain of at least 100% and an elastic limit of at least about 7 MPa. The first rubber material has a modulus measured at 250% elongation of less than about 10 kPa.

公开(公告)号：US12247250B2

公开(公告)日：2025-03-11

申请号：US16941333

申请日：2020-07-28

Applicant: GODX, INC ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES

Inventor： Chang Hee Kim ,  Wendy A. Henderson ,  Sarah K. Abey ,  Nicolaas H. Fourie ,  Eric G. Ferguson

IPC: C12Q1/6834 ,  B01L3/00 ,  C12Q1/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q1/70 ,  G01N15/06 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1433 ,  G01N33/487 ,  G01N15/075

Abstract: The present invention relates to the rapid and electricity-free, point-of-care, multiplexed detection and quantification of at least one or more nucleic acid sequences from nucleic acids corresponding to a plurality of pathogens or biomarkers using a micropatterned lateral flow device. Rapid and molecular-level sensitive differential diagnosis of a disease condition may be enabled without the need for a delayed laboratory test so that timely treatment can be administered.

公开(公告)号：US12245524B2

公开(公告)日：2025-03-04

申请号：US18632077

申请日：2024-04-10

Applicant: PsiQuantum Corp. ,  Government of the United States of America, as Represented by the Secretary of Commerce

Inventor： Faraz Najafi ,  Qiaodan Jin Stone ,  Adam Nykoruk McDaughan

IPC: H01F6/04 ,  H10N60/30 ,  H10N60/84

Abstract: An example electric circuit includes a superconductor component having a first terminal at a first end and a second terminal at a second end. The superconductor component includes a first portion coupled to the first terminal, a second portion coupled to the second terminal, and a third portion coupling the first portion and the second portion. The third portion has a curved shape such that the first portion of the superconductor component is proximate to, and thermally coupled to, the second portion of the superconductor component. The example electric circuit further includes a coupling component coupled to the third portion of the superconductor component, and a gate component configured to generate a resistive heat that exceeds a superconducting threshold temperature of the superconductor component, where the gate component is separated from the superconductor component by the coupling component.

公开(公告)号：US20250067645A1

公开(公告)日：2025-02-27

申请号：US18800684

申请日：2024-08-12

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Andrew J. Birnbaum ,  John C. Steuben ,  Anna Lee Kofer Rawlings ,  Benjamin D. Graber ,  Athanasios Iliopoulos ,  John G. Michopoulos ,  Heonjune Ryou

IPC: G01N3/06 ,  G01N3/08

Abstract: A non-contact material assessment system and method are provided. In embodiments, a system includes: a radiation source generating a pattern of diffracted elements; a detector configured to: capture a first image of a first diffracted element when a sample is in an initial state, and a second image when the sample is in a second state; and capture a first image of a second diffracted element when the sample is in the initial state, and a second image when the sample is in the second state; and a controller to: determine a displacement of the first diffracted element based on the first and second images of the first diffracted element; determine a displacement of the second diffracted element based on the first and second images of the second diffracted element; and determine a characteristic of the sample over based on the displacement of the first and second diffracted elements.

公开(公告)号：US20250066524A1

公开(公告)日：2025-02-27

申请号：US18812134

申请日：2024-08-22

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Grant C. Daniels ,  Meghanne E. Tighe ,  Matthew D. Thum ,  Nickolaus K. Weise

IPC: C08F220/28 ,  B01J20/26 ,  C08F2/22

Abstract: Disclosed herein is a compound made by copolymerizing a poly(ethylene glycol) acrylate with a first acrylate monomer having a first functional group that interacts with a third functional group having a third functional group type selected from anionic groups, cationic groups, or perfluoroalkyl groups. Optionally, the copolymerization includes a second acrylate monomer having a second functional group that interacts with a fourth functional group having a fourth functional group type selected from anionic groups, cationic groups, and perfluoroalkyl groups. The third functional group type and the fourth functional group type are different. When the compound is porous, as when made by high internal phase emulsion polymerization, it may be used for per- and poly-fluoro alkyl substance decontamination.

公开(公告)号：US12233124B2

公开(公告)日：2025-02-25

申请号：US18462340

申请日：2023-09-06

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute For Research in Biomedicine

Inventor： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC: C07K14/115 ,  A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135

Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20250058579A1

公开(公告)日：2025-02-20

申请号：US18934991

申请日：2024-11-01

Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security

Inventor： Joel Zlotnick ,  Jordan Brough ,  Troy Eberhardt ,  Tyra McConnell ,  Elizabeth Gil ,  Traci Moran

IPC: B42D25/29 ,  B41F1/16 ,  B41F7/02 ,  B41F31/00 ,  B41F33/00 ,  B41M1/10 ,  B41M1/14 ,  B41M3/14 ,  B42D25/333 ,  B42D25/342 ,  B42D25/351 ,  B42D25/378 ,  B42D25/405

Abstract: A substrate is printed with front side and back side markings. The front side when viewed with reflected light includes a first marking printed with a first gradient of a first color with increasing intensity from a first edge of the substrate to a second edge of the substrate. The back side when viewed with reflected light includes a second marking printed with a second gradient of the first color with decreasing intensity from the first edge of the substrate to the second edge of the substrate. The first gradient and the second gradient are selected for a combination of the first marking and the second marking, when viewed from the front side with transmitted light, to be seen with a same intensity of the first color at the first edge and the second edge.

公开(公告)号：US12228314B1

公开(公告)日：2025-02-18

申请号：US17661551

申请日：2022-04-30

Applicant: The United States of America, as represented by the Secretary of the Navy

Inventor： Kevin Woods

IPC: F25B30/02 ,  F25B21/02

Abstract: A cascading thermoelectric heat pump employs a stack of cold plates with a series of thermoelectric coolers sandwiched between each adjacent pair of cold plates, allowing for noise-free cooling and heating of a 67° F. water supply, capable of delivering water chilled to about 44° F. and water heated to about 90° F.

公开(公告)号：US12227276B1

公开(公告)日：2025-02-18

申请号：US17840660

申请日：2022-06-15

Applicant: The United States of America as represented by the Secretary of the Navy

Inventor： Paul V Cavallaro ,  Nicholas A Valm ,  Jacob D O'Donnell ,  Michael P Smith

IPC: B63G8/06 ,  B63G8/38

Abstract: An inflatable deployable mast fairing assembly is provided with a rigid foundation, a hydrodynamic fairing and at least one soft actuator. The hydrodynamic fairing is shaped to close an aperture formed between a deployable hardware system and a sail bay opening. A first soft actuator connects to the rigid foundation at one end and to the hydrodynamic fairing at another. Fluid pressurization elongates a first soft actuator coaxial to the deployable hardware system to fittedly position the fairing in the aperture with a void in the fairing to receive the hardware system. If the rigid foundation is sail-mounted, a second soft actuator connects to the sail-mounted foundation opposite the first soft actuator and to a counter flange mechanically connected to the hydrodynamic fairing. A second pressurization elongates the second soft actuator coaxial to the deployable hardware system to retract the hydrodynamic fairing from the aperture.

公开(公告)号：US20250049736A1

公开(公告)日：2025-02-13

申请号：US18718691

申请日：2022-12-15

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH

Inventor： Malliga R. Iyer ,  Biswajit Kundu

IPC: A61K31/155 ,  A61K45/06 ,  A61P37/00 ,  C07C311/59

Abstract: The present invention relates to compounds of formulae I and II. The compounds are useful for treating hypertension, atherosclerosis, pulmonary diseases, diabetes, pain, fibrosis, addictive disorders, inflammation, and immunological disorders or a condition treatable or preventable by inhibition of soluble epoxide hydrolase. Preferred compounds are N-((adamantan-1-yl)carbamoyl)-benzenesulfonamide derivatives. Exemplary compounds are e.g. •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-methylbenzenesulfonamide (example 14, compound 4a) •4-(tert-butyl)-N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)benzenesulfonamide (example 15, compound 4b) •N—(((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)carbamoyl)-4-(trifluoromethyl)benzenesulfonamide (example 16, compound 4j). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof.