公开(公告)号：US20180148774A1

公开(公告)日：2018-05-31

申请号：US15574750

申请日：2016-05-16

申请人： GODX, INC ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HUMAN SERVICES

发明人： Chang Hee Kim ,  Wendy A. Henderson ,  Sarah K. Abey ,  Nicolaas H. Fourie ,  Eric G. Ferguson

IPC分类号： C12Q1/6834 ,  B01L3/00 ,  C12Q1/70 ,  C12Q1/6888 ,  C12Q1/6825

CPC分类号： C12Q1/6834 ,  B01L3/5023 ,  B01L2200/141 ,  B01L2300/069 ,  B01L2400/0406 ,  C12Q1/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q1/701 ,  G01N15/06 ,  G01N15/1056 ,  G01N15/1463 ,  G01N15/1484 ,  G01N33/487 ,  G01N2015/0693 ,  G01N2015/1006 ,  Y02A50/51 ,  Y02A50/52 ,  Y02A50/53 ,  Y02A50/58 ,  C12Q2565/625

摘要： The present invention relates to the rapid and electricity-free, point-of-care, multiplexed detection and quantification of at least one or more nucleic acid sequences from nucleic acids corresponding to a plurality of pathogens or biomarkers using a micropatterned lateral flow device. Rapid and molecular-level sensitive differential diagnosis of a disease condition may be enabled without the need for a delayed laboratory test so that timely treatment can be administered.

公开(公告)号：US11746372B2

公开(公告)日：2023-09-05

申请号：US16768802

申请日：2018-12-03

申请人： GoDX, inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： Chang Hee Kim ,  Lichen Xiang ,  Wendy A. Henderson ,  Xiao Jiang

IPC分类号： C12Q1/6806 ,  C12N15/10 ,  C12Q1/6865

CPC分类号： C12Q1/6806 ,  C12N15/1006 ,  C12Q1/6865 ,  C12Q2527/125 ,  C12Q2531/113 ,  C12Q2531/143 ,  C12Q2563/155

摘要： Disclosed herein are method for separating, amplifying, or detecting a nucleic acid from a sample may comprise contacting a sample lysate with a plurality of buoyant, inorganic, nucleic-acid-capture microspheres. The nucleic-acid-capture microspheres may comprise unicellular hollow microspheres having a diameter between 5 and 300 μm and/or a true particle density between 0.05 and 0.60 grams/cm3. The microspheres may comprise hollow soda-lime-borosilicate microspheres. In some embodiments, the microspheres comprises hollow soda-lime-borosilicate microspheres surrounded by an amorphous silica shell. Also disclosed are kits for performing the methods.

公开(公告)号：US20230227888A1

公开(公告)日：2023-07-20

申请号：US17925223

申请日：2021-05-12

申请人： GoDx, Inc.

发明人： Chang Hee KIM ,  Jacob Jerome TOKAR ,  Xiao JIANG

IPC分类号： C12Q1/68 ,  B01L3/00

CPC分类号： C12Q1/68 ,  B01L3/502715 ,  B01L3/5023 ,  B01L2200/0621 ,  B01L2300/087 ,  B01L2300/18 ,  B01L2400/043 ,  B01L2300/0627 ,  B01L2200/16 ,  B01L2300/025 ,  B01L2300/0681

摘要： The present invention provides point-of-need diagnostic devices and kits for detecting a target nucleic acid sequence in a sample. Methods of using the point-of-need diagnostic devices or the kits disclosed are also provided.

公开(公告)号：US20230160025A1

公开(公告)日：2023-05-25

申请号：US18049552

申请日：2022-10-25

申请人： GoDx, Inc.

发明人： Chang Hee KIM ,  Jacob Jerome TOKAR ,  Fernando R. MOREIRA ,  Xiao JIANG

IPC分类号： C12Q1/70

CPC分类号： C12Q1/701

摘要： The present invention provides compositions comprising primers for loop-mediated isothermal amplification of a target nucleotide sequence of SARS-CoV-2, as well as point-of-care diagnostic devices and kits comprising said compositions. Methods of using the compositions, devices, and kits to detect SARS-CoV-2 in a sample are also provided.

公开(公告)号：US20210180108A1

公开(公告)日：2021-06-17

申请号：US16768802

申请日：2018-12-03

申请人： GoDx, Inc ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEP. OF HEALTH AND HUMAN SERVICES

发明人： Chang Hee KIM ,  Lichen XIANG ,  Wendy A. HENDERSON ,  Xiao JIANG

IPC分类号： C12Q1/6806 ,  C12N15/10 ,  C12Q1/6865

摘要： Disclosed herein are method for separating, amplifying, or detecting a nucleic acid from a sample may comprise contacting a sample lysate with a plurality of buoyant, inorganic, nucleic-acid-capture microspheres. The nucleic-acid-capture microspheres may comprise unicellular hollow microspheres having a diameter between 5 and 300 μm and/or a true particle density between 0.05 and 0.60 grams/cm3. The microspheres may comprise hollow soda-lime-borosilicate microspheres. In some embodiments, the microspheres comprises hollow soda-lime-borosilicate microspheres surrounded by an amorphous silica shell. Also disclosed are kits for performing the methods.