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257 条记录 (耗时 0.02 秒)

    Marker-suicide gene useful in adoptive cell therapy
    41.
    发明授权
    Marker-suicide gene useful in adoptive cell therapy 有权

    公开(公告)号：US10925943B2

    公开(公告)日：2021-02-23

    申请号：US14391536

    申请日：2013-04-11

    申请人： UCL BUSINESS LTD

    发明人： Martin Pulé ,  Brian Philip

    IPC分类号： A61K39/00 ,  G01N33/50 ,  A61K35/14 ,  C07K14/705 ,  C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C12N15/85 ,  A61K48/00

    摘要： The present invention provides a polypeptide having the formula: St-R1-S1-Q-S2-R2 wherein St is a stalk sequence which, when the polypeptide is expressed at the surface of a target cell, causes the R and Q epitopes to be projected from the cell surface; R1 and R2 are a Rituximab-binding epitopes each having the an amino acid sequence selected from the group consisting of SEQ ID No. 1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16 or a variant thereof which retains Rituximab-binding activity; S1 and S2 are optional spacer sequences, which may be the same or different; and Q is a QBEnd1O-binding epitope having the amino acid sequence shown as SEQ ID No. 2 or a variant thereof which QBEnd1O-binding activity. The invention also provides a nucleic acid sequence encoding such a polypeptide and uses thereof in adoptive cell transfer.

    Crystalline diethylamine tetrathiomolybdate and its pharmaceutical uses
    44.
    发明授权
    Crystalline diethylamine tetrathiomolybdate and its pharmaceutical uses 有权

    公开(公告)号：US10781162B2

    公开(公告)日：2020-09-22

    申请号：US16340939

    申请日：2017-10-20

    申请人： UCL BUSINESS Ltd

    发明人： Alex Peter Dyson ,  Daniel Gooding ,  Joanne Holland

    IPC分类号： C07C211/05 ,  C07C209/84 ,  A61P9/10 ,  C07C209/00 ,  A61K9/00

    摘要： The invention relates to a crystalline diethylamine tetrathiomolybdate salt (DEA-TTM). The invention also relates to methods for producing the crystalline DEA-TTM salt of the invention. The invention also relates to pharmaceutical compositions comprising the crystalline DEA-TTM salt of the invention. The invention also relates to the use of the crystalline DEA-TTM salt of the invention in the treatment of the human or animal body, in particular its use in treatment of a condition requiring reduced metabolism of an organ or the whole body of a patient, by administering to a patient in need thereof a therapeutically effective amount of the crystalline DEA-TTM salt.

    A System and Computer-Implemented Method for Segmenting an Image
    45.
    发明申请
    A System and Computer-Implemented Method for Segmenting an Image 审中-公开

    公开(公告)号：US20200167930A1

    公开(公告)日：2020-05-28

    申请号：US16622782

    申请日：2018-06-14

    申请人： UCL BUSINESS LTD

    发明人： Guotai Wang ,  Tom Vercauteren ,  Sebastien Ourselin ,  Wenqi Li ,  Lucas Fidon

    IPC分类号： G06T7/11 ,  G16H30/40 ,  G06N3/08 ,  G06N3/04

    摘要： A computer-implemented method for segmenting an input image, the method comprises: generating a first segmentation of the input image using a first machine learning system, the first segmentation comprising multiple segments; receiving, from a user, at least one indication, wherein each indication corresponds to a particular segment from the multiple segments, and indicates one or more locations of the input image as belonging to that particular segment; constructing, for each segment of the multiple segments having at least one corresponding indication, a respective geodesic distance map, based on the input image and the user indications received for that segment; and generating a second segmentation using a second machine learning system based on the input image and the constructed geodesic distance maps.

    CRYOPRESERVATION
    46.
    发明申请
    CRYOPRESERVATION 审中-公开

    公开(公告)号：US20200163326A1

    公开(公告)日：2020-05-28

    申请号：US16617310

    申请日：2018-06-01

    申请人： UCL BUSINESS LTD

    发明人： PAOLO DE COPPI ,  Luca URBANI ,  Massimo PINZANI ,  Guiseppe MAZZA ,  Claire CROWLEY

    IPC分类号： A01N1/02 ,  A61L27/38 ,  A61K35/545

    摘要： Methods and materials for the cryopreservation of cellularised scaffolds used for therapeutic or pharmacological testing purposes that provide a cultured scaffold on which cells have been seeded, equilibrate the cellularised scaffold with a cryopreservative composition comprising culture medium and between 5 and 30% of a cryoprotectant such as DMSO, freeze the equilibrated cellularised scaffold by reducing the temperature continuously by about −1° C./minute to about −80° C., and store the frozen cellularised scaffold at a temperature of between −135° C. and −198° C.

    METHODS AND APPARATUS FOR OPTICAL FIBRE DESIGN AND PRODUCTION
    49.
    发明公开
    METHODS AND APPARATUS FOR OPTICAL FIBRE DESIGN AND PRODUCTION 审中-公开

    公开(公告)号：US20240264432A1

    公开(公告)日：2024-08-08

    申请号：US18564461

    申请日：2022-05-26

    申请人： UCL Business Ltd.

    发明人： Xun Mu ,  Georgios Zervas ,  Alessandro Ottino ,  Filipe Ferreira

    IPC分类号： G02B27/00 ,  G02B6/02 ,  G06F30/20

    CPC分类号： G02B27/0012 ,  G02B6/02042 ,  G06F30/20

    摘要： Aspects of the present disclosure relate to a method of producing data indicative of a multi-core optical fibre configuration, comprising: (a) determining at least one fibre configuration constraint; (b) determining at least one initial parameter set, each initial parameter set comprising a plurality of initial fibre configuration parameters; (c) calculating a fitness value for each initial parameter set; (d) modifying each initial parameter set to produce at least one modified parameter set, said modifying being to improve the fitness value of at least some of the initial parameter sets; (e) iteratively repeating said modifying until it is determined that a ceasing condition is met; (f) determining whether at least one said modified parameter set satisfies the at least one fibre configuration constraint; (g) responsive to said at least one modified parameter set satisfying the at least one fibre configuration constraint, and based on said modified parameter set, generate data indicative of a multi-core optical fibre configuration; and (h) outputting said data.