公开(公告)号：US20180065967A1

公开(公告)日：2018-03-08

申请号：US15560002

申请日：2016-03-18

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US20170174655A1

公开(公告)日：2017-06-22

申请号：US15238305

申请日：2016-08-16

Applicant: UWM Research Foundation, Inc. ,  Women and Infants' Hospital of Rhode Island

Inventor： Alexander E. Arnold ,  Preetpal Singh Sidhu ,  Premchendar Nandhikonda ,  Rakesh K. Singh

IPC: C07D401/12 ,  C07D209/10 ,  C07D209/14

CPC classification number: C07D401/12 ,  A61K31/404 ,  A61K45/06 ,  C07D209/10 ,  C07D209/14 ,  C07D209/16 ,  C07D407/12 ,  A61K2300/00

Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.

公开(公告)号：US20170085122A1

公开(公告)日：2017-03-23

申请号：US15076358

申请日：2016-03-21

Applicant: General Electric Company ,  UWM Research Foundation, Inc.

Inventor： Adel Nasiri ,  Seyed Ahmad Hamidi ,  Russell Wayne Hum ,  John Ferdinand Bopp

IPC: H02J9/06 ,  A61B6/00 ,  H02J7/00

CPC classification number: H02J9/061 ,  A61B6/032 ,  A61B6/56

Abstract: A system includes an AC-DC converter configured to convert power from an AC supply to a DC bus to provide a first portion of power a medical imaging load. The system includes an uninterruptible power supply (UPS) coupled to the DC bus. The UPS comprises at least one battery cell and a DC-DC converter comprising one or more switches and coupled between the at least one battery cell and the DC bus. The system includes a control system comprising a processor configured to send one or more signals to control operation of the one or more switches to cause the DC-DC converter to control power discharged from the at least one battery cell to the DC bus to provide a second portion of power to the medical imaging load.

公开(公告)号：US20150258128A1

公开(公告)日：2015-09-17

申请号：US14637334

申请日：2015-03-03

Applicant: UWM Research Foundation, Inc.

Inventor： James M. Cook ,  Terry S. Clayton ,  Hiteshkumar D. Jain ,  Yun Teng Johnson ,  Jie Yang ,  Sundari K. Rallipalli ,  Zhi-jian Wang ,  Ojas A. Namjoshi ,  Michael Ming-Jin Poe

IPC: A61K31/695 ,  A61K31/551

CPC classification number: A61K31/695 ,  A61K31/551 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

Abstract translation: 本文描述的是α3或α2或α2/α3GABA能受体亚型选择性配体，药物组合物，以及这些配体和组合物在治疗焦虑症，癫痫和精神分裂症以及降低镇静和共济失调副作用中的应用的方法。 在实施方案中，诸如α3或α2或α2/α3GABA能受体亚型选择性配体缺少酯键，因此可能因酯酶水解而相对不敏感。

公开(公告)号：US20140137324A1

公开(公告)日：2014-05-22

申请号：US14060250

申请日：2013-10-22

Applicant: UWM Research Foundation, Inc.

Inventor： Jennifer J. Doering ,  Greg Krzecki

IPC: A47D9/00

CPC classification number: A47D9/00 ,  A47D7/04

Abstract: An infant sleep pod providing passive and/or active safety features. The infant sleep pod provides a safe sleeping environment for infants sharing sleep areas with adults. The infant sleep pod provides a firm, flat, separate, portable, and dedicated sleep space for an infant. The infant sleep pod includes a base with a bed and sidewall, and a bridge extending across the bed. The bridge covers a head portion of the bed, while a foot portion of the bed is left open for inserting and removing the infant. The bridge prevents pillows and blankets from covering the bed and infant. The infant sleep pod also includes electronics for monitoring the sleep pod. The electronics include a sensor unit in the bridge and a control unit in communication with the sensor unit. The control unit and sensor unit are operable to detect unsafe conditions and, in response, generate alerts.

Abstract translation: 婴儿睡眠荚提供被动和/或主动的安全特征。 婴儿睡眠荚为与成年人共享睡眠区域的婴儿提供安全的睡眠环境。 婴儿睡眠荚为婴儿提供坚实，平坦，独立，便携和专用的睡眠空间。 婴儿睡眠荚包括具有床和侧壁的基部，以及延伸穿过床的桥。 桥覆盖床的头部，而床的脚部保持打开以插入和移除婴儿。 桥梁防止枕头和毯子覆盖床和婴儿。 婴儿睡眠荚还包括用于监测睡眠荚的电子装置。 电子装置包括桥中的传感器单元和与传感器单元通信的控制单元。 控制单元和传感器单元可操作以检测不安全状况，并作为响应产生警报。

公开(公告)号：US12167733B2

公开(公告)日：2024-12-17

申请号：US18103082

申请日：2023-01-30

Applicant: T3 BIOSCIENCE, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  A61K35/74 ,  C07D213/90 ,  C07D491/048 ,  C12N1/20

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US12065658B2

公开(公告)日：2024-08-20

申请号：US16959928

申请日：2019-01-03

Applicant: UWM Research Foundation, Inc. ,  United States of America, As Represented by the Secretary of Agriculture

Inventor： Dazhong Zhao ,  Zhanguo Xin

IPC: C12N15/82

CPC classification number: C12N15/8289

Abstract: Disclosed herein are nuclear male sterile sorghum mutants, three-component genetic constructs, and methods of using said mutants and genetic constructs, such as in a two-line male sterility system for hybrid breeding.

公开(公告)号：US12054491B2

公开(公告)日：2024-08-06

申请号：US17886403

申请日：2022-08-11

Applicant: UWM Research Foundation, Inc. ,  The Trustees of Columbia University in the City of New York

Inventor： Alexander E. Arnold ,  Douglas C. Stafford ,  James M. Cook ,  Charles W. Emala ,  Gloria Forkuo ,  Rajwana Jahan ,  Revathi Kodali ,  Guanguan Li ,  Michael Rajesh Stephen

IPC: C07D487/04 ,  A61P11/06 ,  C07D487/14

CPC classification number: C07D487/14 ,  A61P11/06 ,  C07D487/04

Abstract: The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I):




wherein R1, R2, R2′, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.

公开(公告)号：US11959875B2

公开(公告)日：2024-04-16

申请号：US16631104

申请日：2018-08-10

Applicant: UWM Research Foundation, Inc.

Inventor： Woo-Jin Chang ,  Misong Ryu ,  Mohammad Rizwen Ur Rahman

IPC: G01N27/333 ,  G01N27/30 ,  G01N27/48 ,  G01N33/18

CPC classification number: G01N27/333 ,  G01N27/307 ,  G01N27/308 ,  G01N27/48 ,  G01N33/182

Abstract: Composition and electrode for phosphate sensing. In one embodiment, the composition includes a first component, a second component, and a third component. The first component is selected from a group consisting of cobalt oxide nanoparticles, tin (IV) chloride, diphenyl tin dichloride, and ammonium molybdate. The second component includes graphene oxide or reduced graphene oxide. The third component includes pyrrole or polypyrrole.

公开(公告)号：US20230285472A1

公开(公告)日：2023-09-14

申请号：US18120528

申请日：2023-03-13

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K35/74 ,  A61K31/05 ,  A61P31/04

CPC classification number: A61K35/74 ,  A61K31/05 ,  A61P31/04

Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.