公开(公告)号：US20050137633A1

公开(公告)日：2005-06-23

申请号：US10744952

申请日：2003-12-22

申请人： Rodney Salo ,  Bruce KenKnight ,  Joseph Pastore ,  Steven Girouard

发明人： Rodney Salo ,  Bruce KenKnight ,  Joseph Pastore ,  Steven Girouard

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.

摘要翻译： 用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。 内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

公开(公告)号：US20050107837A1

公开(公告)日：2005-05-19

申请号：US11018124

申请日：2004-12-21

申请人： Rodney Salo ,  Kenneth Baker ,  Lawrence Baumann

发明人： Rodney Salo ,  Kenneth Baker ,  Lawrence Baumann

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3688

摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.

摘要翻译： 公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。 微控制器可操作以调节起搏器的起搏模式和站间延迟，以达到最佳的血液动力学性能。 信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。 当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

公开(公告)号：US20050096706A1

公开(公告)日：2005-05-05

申请号：US10979073

申请日：2004-11-01

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

摘要： Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

摘要翻译： 心脏起搏方法涉及感测左心室电节律，感测左心室血流速度，以及感测冠状静脉血液温度。 所述方法还包括至少部分地基于感测的冠状静脉血液温度和感测的左心室流率来修改同步电信号到患者心脏的传送。

公开(公告)号：US20050049510A1

公开(公告)日：2005-03-03

申请号：US10653460

申请日：2003-09-02

申请人： Paul Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Carlson

发明人： Paul Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Carlson

IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B8/12

CPC分类号： A61B5/489 ,  A61B5/01 ,  A61B5/02 ,  A61B8/12 ,  A61B2562/0219

摘要： A guiding catheter for use in medical procedures includes a flexible shaft with one or more audio transducers and a distal tip. An audio signal may be sent to one or more of the transducers and a reflected signal is received at one or more transducers. The reflected signal is used to detect the presence of an anatomical structure to assist in navigating the catheter to its destination. In another arrangement, the transducer can be used passively to detect physical characteristics of the heart such as sound, subsonic energy or temperature, that indicate relative proximity of a destination vessel.

摘要翻译： 用于医疗过程的引导导管包括具有一个或多个音频换能器的柔性轴和远端。 可将音频信号发送到一个或多个换能器，并且在一个或多个换能器处接收反射信号。 反射信号用于检测解剖结构的存在以帮助将导管导航到其目的地。 在另一种布置中，换能器可被动地用于检测心脏的物理特性，例如声音，亚音速能量或温度，其指示目的血管的相对接近度。

公开(公告)号：US09265949B2

公开(公告)日：2016-02-23

申请号：US11168024

申请日：2005-06-28

申请人： Rodney Salo ,  Joseph M. Pastore ,  Andrew P. Kramer ,  Jeffrey E. Stahmann ,  Jesse W. Hartley

发明人： Rodney Salo ,  Joseph M. Pastore ,  Andrew P. Kramer ,  Jeffrey E. Stahmann ,  Jesse W. Hartley

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61M5/142 ,  A61N1/365 ,  A61N1/375

CPC分类号： A61N1/3627 ,  A61M5/14276 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3756

摘要： Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

公开(公告)号：US09155896B2

公开(公告)日：2015-10-13

申请号：US11316123

申请日：2005-12-22

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/00 ,  A61B5/04 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36557

摘要： Devices and methods for improving cardiac efficiency involve measuring, patient-internally, an oxygen saturation parameter indicative of oxygen usage of myocardial tissue of the heart. A cardiac electrical therapy is adjusted to cause a change of the measured oxygen saturation parameter, and the adjusted cardiac electrical therapy is selected for delivery based on a changed oxygen saturation parameter indicative of an increase in cardiac efficiency.

摘要翻译： 用于改善心脏功能的装置和方法包括测量患者内部的指示心脏心肌组织的氧气使用的氧饱和度参数。 调整心脏电疗法以引起测量的氧饱和度参数的变化，并且基于改变的氧饱和度参数来选择调整后的心电疗法用于递送，所述改变的氧饱和度参数指示心脏效率的增加。

公开(公告)号：US08571657B2

公开(公告)日：2013-10-29

申请号：US12221332

申请日：2008-08-01

申请人： Rodney Salo ,  Angelo Auricchio

发明人： Rodney Salo ,  Angelo Auricchio

IPC分类号： A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

摘要： Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

摘要翻译： 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

公开(公告)号：US08000771B2

公开(公告)日：2011-08-16

申请号：US10653460

申请日：2003-09-02

申请人： Paul Craig Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Merrill Carlson

发明人： Paul Craig Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Merrill Carlson

IPC分类号： A61B5/05

CPC分类号： A61B5/489 ,  A61B5/01 ,  A61B5/02 ,  A61B8/12 ,  A61B2562/0219

摘要： A guiding catheter for use in medical procedures includes a flexible shaft with one or more audio transducers and a distal tip. An audio signal may be sent to one or more of the transducers and a reflected signal is received at one or more transducers. The reflected signal is used to detect the presence of an anatomical structure to assist in navigating the catheter to its destination. In another arrangement, the transducer can be used passively to detect physical characteristics of the heart such as sound, subsonic energy or temperature, that indicate relative proximity of a destination vessel.

摘要翻译： 用于医疗过程的引导导管包括具有一个或多个音频换能器的柔性轴和远端。 可将音频信号发送到一个或多个换能器，并且在一个或多个换能器处接收反射信号。 反射信号用于检测解剖结构的存在以帮助将导管导航到其目的地。 在另一种布置中，换能器可被动地用于检测心脏的物理特征，例如声音，亚音速能量或温度，其指示目的地血管的相对接近度。

公开(公告)号：US20100222833A1

公开(公告)日：2010-09-02

申请号：US12778779

申请日：2010-05-12

申请人： Rodney Salo ,  Abhijeet Chavan

发明人： Rodney Salo ,  Abhijeet Chavan

IPC分类号： A61N1/39 ,  A61B5/02 ,  A61M5/00 ,  A61N1/365

CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/3925

摘要： A system and method for administering a therapeutic treatment to the heart includes a pressure sensor positioned in the pulmonary artery, an implantable medical device located remotely from the sensor, and communication means for communicating pressure data from the pressure sensor to the implantable medical device. The system includes a control module operatively coupled to the implantable medical device. The control module is adapted for comparing the pulmonary arterial pressure data to a pre-programmed value, adjusting an operating parameter of the implantable medical device based on the relationship of the pulmonary arterial pressure to the pre-programmed value, and repeating this process until the relationship between the pulmonary arterial pressure data and the pre-programmed value is such that no adjustment is necessary.

摘要翻译： 用于向心脏施用治疗性治疗的系统和方法包括定位在肺动脉中的压力传感器，远离传感器定位的可植入医疗装置，以及用于将来自压力传感器的压力数据传送到可植入医疗装置的连通装置。 该系统包括可操作地耦合到可植入医疗装置的控制模块。 控制模块适于将肺动脉压数据与预编程值进行比较，基于肺动脉压与预编程值的关系来调整可植入医疗装置的操作参数，并重复该过程直到 肺动脉压数据与预编程值之间的关系使得不需要调整。

公开(公告)号：US20080097538A1

公开(公告)日：2008-04-24

申请号：US11931779

申请日：2007-10-31

申请人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3627

摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.

摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。