公开(公告)号：US20080097541A1

公开(公告)日：2008-04-24

申请号：US11931718

申请日：2007-10-31

申请人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3627

摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.

公开(公告)号：US20060293716A1

公开(公告)日：2006-12-28

申请号：US11469620

申请日：2006-09-01

申请人： Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

公开(公告)号：US20080097538A1

公开(公告)日：2008-04-24

申请号：US11931779

申请日：2007-10-31

申请人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/3627

摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.

摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

公开(公告)号：US20050288720A1

公开(公告)日：2005-12-29

申请号：US10862011

申请日：2004-06-04

申请人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

发明人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.

摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。

公开(公告)号：US20080091138A1

公开(公告)日：2008-04-17

申请号：US11998969

申请日：2007-12-03

申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US20070260284A1

公开(公告)日：2007-11-08

申请号：US11381211

申请日：2006-05-02

申请人： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

发明人： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/3956

摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。

公开(公告)号：US20060259088A1

公开(公告)日：2006-11-16

申请号：US11129058

申请日：2005-05-13

申请人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

发明人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC分类号： A61N1/362

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/37205 ,  A61N1/3787 ,  A61N2001/0585

摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

公开(公告)号：US20070054871A1

公开(公告)日：2007-03-08

申请号：US11220397

申请日：2005-09-06

申请人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

发明人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

IPC分类号： A61K48/00 ,  A61N1/00

CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

公开(公告)号：US20060025661A1

公开(公告)日：2006-02-02

申请号：US10909926

申请日：2004-08-02

申请人： Robert Sweeney ,  Julio Spinelli ,  Rodney Salo

发明人： Robert Sweeney ,  Julio Spinelli ,  Rodney Salo

IPC分类号： A61B5/05

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61B5/14535 ,  A61N1/36521

摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.

摘要翻译： 描述了通过电阻抗测量来确定患者的血细胞比容的技术。 可植入装置可被配置为利用该技术来评估心脏病人的流体状态。 为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

公开(公告)号：US20050043675A1

公开(公告)日：2005-02-24

申请号：US10645823

申请日：2003-08-21

申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC分类号： A61B5/00 ,  A61B5/11 ,  A61M5/142 ,  A61M5/172 ,  A61M31/00 ,  A61N1/362

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。