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    Method and apparatus for catheterization by detecting signals indicating proximity to anatomical features
    1.
    发明申请
    Method and apparatus for catheterization by detecting signals indicating proximity to anatomical features 失效
    通过检测指示接近解剖特征的信号进行导管插入的方法和装置

    公开(公告)号：US20050049510A1

    公开(公告)日：2005-03-03

    申请号：US10653460

    申请日：2003-09-02

    申请人： Paul Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Carlson

    发明人： Paul Haldeman ,  Rodney Salo ,  Bruce Tockman ,  Gerrard Carlson

    IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B8/12

    CPC分类号： A61B5/489 ,  A61B5/01 ,  A61B5/02 ,  A61B8/12 ,  A61B2562/0219

    摘要： A guiding catheter for use in medical procedures includes a flexible shaft with one or more audio transducers and a distal tip. An audio signal may be sent to one or more of the transducers and a reflected signal is received at one or more transducers. The reflected signal is used to detect the presence of an anatomical structure to assist in navigating the catheter to its destination. In another arrangement, the transducer can be used passively to detect physical characteristics of the heart such as sound, subsonic energy or temperature, that indicate relative proximity of a destination vessel.

    摘要翻译： 用于医疗过程的引导导管包括具有一个或多个音频换能器的柔性轴和远端。 可将音频信号发送到一个或多个换能器，并且在一个或多个换能器处接收反射信号。 反射信号用于检测解剖结构的存在以帮助将导管导航到其目的地。 在另一种布置中，换能器可被动地用于检测心脏的物理特性，例如声音，亚音速能量或温度，其指示目的血管的相对接近度。

    Method and apparatus for using heart rate variability as a safety check in electrical therapies
    3.
    发明申请
    Method and apparatus for using heart rate variability as a safety check in electrical therapies 失效
    使用心率变异性作为电疗法安全检查的方法和装置

    公开(公告)号：US20060161209A1

    公开(公告)日：2006-07-20

    申请号：US11037309

    申请日：2005-01-18

    申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

    发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/365 ,  A61N1/36592

    摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

    摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

    THIRD HEART SOUND ACTIVITY INDEX FOR HEART FAILURE MONITORING
    5.
    发明申请
    THIRD HEART SOUND ACTIVITY INDEX FOR HEART FAILURE MONITORING 有权
    心脏失败监测的第三心音活动指标

    公开(公告)号：US20070078491A1

    公开(公告)日：2007-04-05

    申请号：US11465878

    申请日：2006-08-21

    申请人： Krzysztof Siejko ,  Laura Green ,  Gerrard Carlson

    发明人： Krzysztof Siejko ,  Laura Green ,  Gerrard Carlson

    IPC分类号： A61N1/00

    CPC分类号： A61B7/006 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02438 ,  A61B5/4836 ,  A61B5/6847 ,  A61B5/7275 ,  A61B7/04 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/36514 ,  A61N1/37 ,  A61N1/3987

    摘要： A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart beats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.

    摘要翻译： 心律管理系统提供第三心音（S3）指数的趋势。 S3指数是S3跳动次数与所有心跳次数的比率或比率的估计，其中S3跳动各自是检测到S3的发生的心跳。 诸如加速度计或麦克风的可植入传感器感测到包括S3的指示心音的声信号。 S3检测器从声信号检测出S3的发生。 心脏声音处理系统周期性地推动S3指数，以允许连续监测S3活动水平，这表明与心力衰竭有关的病症。

    System and method for assessing cardiac performance through cardiac vibration monitoring
    6.
    发明申请
    System and method for assessing cardiac performance through cardiac vibration monitoring 有权
    通过心脏振动监测评估心脏性能的系统和方法

    公开(公告)号：US20060155204A1

    公开(公告)日：2006-07-13

    申请号：US11367852

    申请日：2006-03-03

    申请人： Ramesh Wariar ,  Gerrard Carlson

    发明人： Ramesh Wariar ,  Gerrard Carlson

    IPC分类号： A61B5/02

    CPC分类号： A61B7/04 ,  A61B5/021 ,  A61B7/00

    摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.

    摘要翻译： 描述了通过心脏振动监测来评估心脏性能的系统和方法。 通过植入式医疗设备直接收集心脏振动。 识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。 第一个心音与胸腔内压力作用的心脏尺寸相关。 心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。 针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。

    Systems and methods for multi-axis cardiac vibration measurements
    8.
    发明申请
    Systems and methods for multi-axis cardiac vibration measurements 有权
    用于多轴心脏振动测量的系统和方法

    公开(公告)号：US20060270939A1

    公开(公告)日：2006-11-30

    申请号：US11135985

    申请日：2005-05-24

    申请人： Ramesh Wariar ,  Krzysztof Siejko ,  Gerrard Carlson ,  Jeffrey Stahmann

    发明人： Ramesh Wariar ,  Krzysztof Siejko ,  Gerrard Carlson ,  Jeffrey Stahmann

    IPC分类号： A61B5/02

    CPC分类号： A61B7/00 ,  A61N1/08

    摘要： A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.

    摘要翻译： 监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。 该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与 病人的心。 该装置还包括耦合到心脏声音传感器的控制器电路。 控制器电路测量分别对应于每个轴的心音的分量。

    STATISTICAL METHOD FOR ASSESSING AUTONOMIC BALANCE
    9.
    发明申请
    STATISTICAL METHOD FOR ASSESSING AUTONOMIC BALANCE 有权
    用于评估自动平衡的统计方法

    公开(公告)号：US20060195038A1

    公开(公告)日：2006-08-31

    申请号：US11382568

    申请日：2006-05-10

    申请人： Gerrard Carlson ,  Ronald Berger

    发明人： Gerrard Carlson ,  Ronald Berger

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/02405 ,  A61B5/4035 ,  A61N1/3622

    摘要： A computationally efficient method for assessing a subject's autonomic balance by measurement of heart rate variability is disclosed which is particularly suitable for implementation by an implantable medical device. Statistical surrogates are used to represent frequency components of an RR time series. A ratio of the low frequency component to the high frequency component may then be estimated to assess the subject's autonomic balance.

    摘要翻译： 公开了一种通过测量心率变异性来评估受试者的自主平衡的计算上有效的方法，其特别适用于可植入医疗装置的实现。 统计代理用于表示RR时间序列的频率分量。 然后可以估计低频分量与高频分量的比率以评估受试者的自主平衡。