公开(公告)号：US20090143385A1

公开(公告)日：2009-06-04

申请号：US12277331

申请日：2008-11-25

申请人： Bernd Buettelmann ,  Roland Jakob-Roetne ,  Henner Knust ,  Andrew Thomas

发明人： Bernd Buettelmann ,  Roland Jakob-Roetne ,  Henner Knust ,  Andrew Thomas

IPC分类号： A61K31/5377 ,  C07D413/02 ,  C07D413/14 ,  A61K31/501

CPC分类号： C07D413/12 ,  C07D413/14 ,  C07D487/04

摘要： The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the treatment of cognitive disorders like Alzheimer's disease.

摘要翻译： 本发明涉及异恶唑并哒嗪化合物，特别是上述式I化合物及其可药用盐，对GABA Aα5受体结合位点具有亲和力和选择性，其制备方法，含有它们的药物组合物及其作为 认知增强剂或用于治疗认知障碍如阿尔茨海默病。

公开(公告)号：US07454090B2

公开(公告)日：2008-11-18

申请号：US09788422

申请日：2001-02-21

申请人： Lawrence Wilcock ,  Michael P. Spratt ,  Andrew Thomas

发明人： Lawrence Wilcock ,  Michael P. Spratt ,  Andrew Thomas

IPC分类号： G06K9/60

CPC分类号： H04N1/32122 ,  G06F17/30265 ,  G06F17/30274 ,  G06F17/30277 ,  H04N1/00127 ,  H04N1/00132 ,  H04N1/00172 ,  H04N1/00196 ,  H04N1/00204 ,  H04N1/00281 ,  H04N1/00307 ,  H04N2201/3253

摘要： A method is provided for augmenting a set of image recordings in which, in addition to making image recordings (95), location data (175) is recorded for locations for which the user desires an, or a further, image recording. This desired-image-recording location data is subsequently used to retrieve one or more corresponding image recordings from a service system (40).

摘要翻译： 提供了一种用于增加一组图像记录的方法，其中除了进行图像记录（95）之外，还记录了用户期望的位置或进一步的图像记录的位置数据（175）。 该期望的图像记录位置数据随后用于从服务系统（40）检索一个或多个对应的图像记录。

公开(公告)号：US20070251485A1

公开(公告)日：2007-11-01

申请号：US11659724

申请日：2005-08-31

申请人： Andrew Thomas ,  Anthony Wallis

发明人： Andrew Thomas ,  Anthony Wallis

IPC分类号： F01L7/16

CPC分类号： F01L7/02 ,  F01L7/023 ,  F01L7/024 ,  F01L7/16 ,  F01L2820/01

摘要： A sealing system for an axial flow rotary valve internal combustion engine comprising an array of floating gas seals and an optional oil sealing system. The array of floating seals surrounding a window (15) in the bore (11) of the cylinder head (10) through which the ports (2, 3) of the valve (1) communicate with a combustion chamber (31). The array of floating seals comprising axial seals (16) and circumferential seals (17) housed in slots (18, 19) in the bore of the cylinder head wherein the circumferential seals are disposed axially between the ends of the axial seals.

摘要翻译： 一种用于轴流式旋转阀内燃机的密封系统，包括浮动气体密封件阵列和可选的油封系统。 围绕气缸盖（10）的孔（11）中的窗口（15）的浮动密封件阵列，阀（1）的端口（2,3）通过其与燃烧室（31）连通。 浮动密封件的阵列包括容纳在气缸盖的孔中的槽（18,19）中的轴向密封件（16）和周向密封件（17），其中周向密封件轴向地设置在轴向密封件的端部之间。

公开(公告)号：US20070082936A1

公开(公告)日：2007-04-12

申请号：US11543178

申请日：2006-10-04

申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

IPC分类号： A61K31/42 ,  C07D413/02

CPC分类号： C07D413/14

摘要： The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula I wherein R1, R2, R3, R4, and R5 are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. The invention also relates to methods for preparing such compounds. This class of compounds has a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. Thus, the invention also is concerned with pharmaceutical compositions containing compounds of formula I or their pharmaceutically acceptable acid addition salts and methods for the treatment of GABA A α5 mediated diseases, including Alzheimer's disease.

摘要翻译： 本发明涉及式I的芳基 - 异恶唑-4-羰基 - 吲哚 - 羧酸酰胺衍生物，其中R 1，R 2，R 3， R 4，R 4和R 5如说明书和权利要求书及其药学上可接受的酸加成盐所定义。 本发明还涉及制备这些化合物的方法。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可能作为认知增强剂或治疗阿尔茨海默病等认知障碍。 因此，本发明还涉及含有式I化合物或其药学上可接受的酸加成盐的药物组合物和用于治疗包括阿尔茨海默氏病在内的GABA Aα5介导的疾病的方法。

公开(公告)号：US20070066668A1

公开(公告)日：2007-03-22

申请号：US11520394

申请日：2006-09-13

申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

IPC分类号： A61K31/42 ,  C07D413/02

CPC分类号： C07D413/14 ,  C07D413/06 ,  C07D451/06

摘要： The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula wherein R1, R2, R3, R4, and R5, and m are as defined herein and with their pharmaceutically acceptable acid addition salts. This class of compounds have high affinity and selectivity for GABA A α5 receptor binding sites and therefore may be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

摘要翻译： 本发明涉及下式的芳基 - 异恶唑-4-羰基 - 吡咯-2-羧酸酰胺衍生物其中R 1，R 2，R 3， R 4，R 4和R 5，m如本文所定义，并与其药学上可接受的酸加成盐反应。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，因此可用作认知增强剂或治疗认知障碍如阿尔茨海默病。

公开(公告)号：US07113911B2

公开(公告)日：2006-09-26

申请号：US09990768

申请日：2001-11-21

申请人： Stephen John Hinde ,  Paul St John Brittan ,  Marianne Hickey ,  Lawrence Wilcock ,  Guillaume Belrose ,  Andrew Thomas

发明人： Stephen John Hinde ,  Paul St John Brittan ,  Marianne Hickey ,  Lawrence Wilcock ,  Guillaume Belrose ,  Andrew Thomas

IPC分类号： G10L21/00

CPC分类号： G10L15/30 ,  H04M3/4938 ,  H04M2201/40 ,  H04M2201/60

摘要： A local entity without its own means of voice communication is provided with the semblance of having a voice interaction capability. This is done by providing a beacon device at or near the entity, the beacon device transmitting, over a short-range communication link, contact data identifying a voice service associated with, but hosted separately from, the entity. The transmitted contact data is picked up by equipment carried by a nearby person and used to contact the voice service over a wireless network. The person then interacts with the voice service, the latter acting as a voice proxy for the local entity. The contact data can be presented to the user in other ways, for example, by being inscribed on the local entity for scanning or user input into the equipment.

公开(公告)号：US06999564B1

公开(公告)日：2006-02-14

申请号：US10113696

申请日：2002-03-29

申请人： Andrew Thomas

发明人： Andrew Thomas

IPC分类号： H04M1/64

CPC分类号： H04M3/42204

摘要： Accordingly, there is provided, a method of connecting users of a telecommunications system, the method comprising, receiving a call, playing a prompt in response to the call, receiving voice data, processing voice data to extract keyword information from the voice data, determining signaling information from the keyword data, and connecting the call based on the signaling information.

摘要翻译： 因此，提供了一种连接电信系统的用户的方法，所述方法包括：接收呼叫，响应于呼叫播放提示，接收语音数据，处理语音数据以从语音数据中提取关键字信息，确定 从关键字数据发送信息，并根据信令信息连接呼叫。

公开(公告)号：US20050131000A1

公开(公告)日：2005-06-16

申请号：US10507081

申请日：2003-03-06

申请人： Nicholas Newcombe ,  Andrew Thomas

发明人： Nicholas Newcombe ,  Andrew Thomas

IPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/63 ,  A61P1/00 ,  A61P1/16 ,  A61P1/18 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/12 ,  A61P17/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P21/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D43/14

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D417/14

摘要： Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

摘要翻译： 式（I）化合物：其中R 1，R 2，R 3，R 4，R 4，R p和p如上所定义，并且描述了药学上可接受的盐和体内可水解的酯。 还描述了它们的制备方法及其作为药物的用途，特别是用于在温血动物如人中产生细胞周期抑制（抗细胞增殖）作用的药物。

公开(公告)号：US20050119291A1

公开(公告)日：2005-06-02

申请号：US10507163

申请日：2003-03-06

申请人： Nicholas Newcombe ,  Andrew Thomas

发明人： Nicholas Newcombe ,  Andrew Thomas

IPC分类号： A61K31/635 ,  A61P9/10 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  C07D403/04 ,  A61K31/506 ,  C07D43/02

CPC分类号： C07D403/04

摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6 and p are as defined within and a pharmaceutically acceptable salts and (in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

摘要翻译： 其中R 1，R 2，R 3，R 4，R 4，R 4，R 4， 另外还描述了它们的制备方法及其作为药物的用途，其中R 1，R 2，R 3，R 5， 特别是用于在温血动物如人中产生细胞周期抑制（抗细胞增殖）作用的药物。

公开(公告)号：US20050114234A1

公开(公告)日：2005-05-26

申请号：US10719867

申请日：2003-11-21

申请人： Andrew Thomas ,  Mark Skrebels ,  Stewart Irvine

发明人： Andrew Thomas ,  Mark Skrebels ,  Stewart Irvine

IPC分类号： G06F21/00 ,  H04L29/06 ,  G06F17/60

CPC分类号： G06F21/10 ,  G06F2221/0797 ,  G06F2221/2137 ,  G06Q10/087 ,  H04L2463/101

摘要： A program controller is arranged to automatically authorize or configure or upgrade a program for a customer replaceable card of a system, the controller being arranged to manage the program automatically, according to a licence agreement, and according to a stored history of use of the hardware module. A supplier can track customer changes and enforce more easily different conditions for authorising the program on, different modules from different sources, having different levels of capability. There can be less interaction with the supplier to get specific authorizations. The history can be stored on the module. It can be used to ease inventory tracking and generate billing information.

摘要翻译： 程序控制器被配置为自动授权或配置或升级系统的客户可更换卡的程序，所述控制器被安排为根据许可协议自动管理程序，并根据存储的硬件使用历史 模块。 供应商可以跟踪客户变更，并更轻松地执行不同的条件来授权程序，来自不同来源的不同模块，具有不同的功能级别。 与供应商的互动可以减少获得特定的授权。 历史可以存储在模块上。 它可用于缓解库存跟踪并生成结算信息。